Prof. Dr. Rasmus Linser
Technische Universität Dortmund
Fakultät für Chemie und Chemische Biologie
Phone: +49 231 755 3910
Fax.: +49 231 755 5367
Phone: +49 231 755 5030
Structure and dynamics are usually what determines the function of a protein in the cell. Even though one of the two can sometimes play a more important role than the other, or only a transient structure is formed in the course of protein interactions, only the combination of both provides a faithful representation of the molecular behavior. Nuclear Magnetic Resonance (NMR) spectroscopy is able to deliver information on both such parameters in a range of molecular sizes and dynamics time scales. Structural information is obtained by a characterization of chemical shifts, interatomic distances, and the size and direction of other interactions, whereas dynamics are mostly represented by the lifetimes of different non-equilibrium states in addition to internuclear interactions. The Linser group develops and uses state-of-the-art NMR spectroscopic tools for the understanding of protein structural and dynamic features that govern their functionality. We employ both, solid-state NMR as well as solution NMR spectroscopy, both in terms of method development and applications. One of our major foci is to use the rich information content of protons for solid-state NMR purposes, i. e. unambiguous resonance assignment, protein structure, and protein dynamics, but there are many more topics of interest, and many more ways in which NMR can solve biological questions. As we are still expanding our group please do not hesitate to contact us for current opportunities to join the team.
Some presentations of what we do:
See our (overview) Accounts paper on "Protons in Solid-State NMR"!
See Rasmus presenting our work in the MIT Boston Zoominar (10.05.22).
Oral presentation of our research in the recent ICMRBS seminar series (second talk, from minute 39.21)!
See a short article about solid-state NMR relaxation activities of our Group (German).
Our work on combining 5D and 4D side chain to backbone solid-state NMR experiments is out in J. Phys. Chem. Lett.!
Alex' mega paper (with a content of multiple papers) is accepted in PNAS, just in time before his defense!
Roman Pallach's work on frustrated MOFs (Sebastian Henke's group) makes its way into Nat. Commun., featuring a small contribution of ours. Congrats and thanks for being part of it!
Congrats to Jelena for successfully defending her Master's thesis.
Congrats to Kristof for successfully defending his PhD thesis!
Himanshu's paper in Angewandte Chemie is out. Here we show how the long-standing assumption of hCAII as a protein with a particularly rigid active site has to be revised. Read more about it on the instititute's webpage (in German).
Kristof's paper in Structure, Cell Press, on assessing structural dynamics via combined methodology is now published! Please contact us personally in case of access problems.
Petra's paper received one of the Center for NanoScience (CeNS) 2019 publication awards! Congratulations!
Himanshu's and Katja's papers can now be read online! Congratulations! (See entries 54 and 55 in the list of publications.)
Julia (PhD) and Laura (postdoc) are joining, welcome to the two of you!
Kristof's paper on exact (eRFDR) distances from solid-state NMR is accepted! Congrats, Kristof!
(Also this paper is featured on the cover page!)
Suresh's Angewandte paper on fast-MAS solid-state NMR on a large enzyme without deuteration is accepted and featured on the cover page!
(Also see the related press releases on TU Dortmund website.)
Welcome Benedict for his Master's thesis!
Sara will join! We are looking forward to you!
As the chair for biomolecular NMR (Lehrstuhl für biomolekulare NMR), the Linser group will be moving to TU Dortmund (from spring 2019), associated with the MPI for molecular physiology and the Max-Planck graduate school for chemical and molecular biology. A huge package of new equipment, space, positions, and research opportunities is waiting.
Ekaterina is joining! Welcome to the group!
Alex will join the group as a PhD student! Welcome, Alex! We are looking forward to you!
Petra wins the "Journal of Magnetic Resonance Young Scientist Award” at the annual EUROMAR conference! Congratulations!
"Felix Bloch Lecture" award ceremony (MARS, January 2016
Portrait about Rasmus Linser's Emmy Noether Research Group in the MPIbpc News, May 2015
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Location & approach
The campus of TU Dortmund University is located close to interstate junction Dortmund West, where the Sauerlandlinie A 45 (Frankfurt-Dortmund) crosses the Ruhrschnellweg B 1 / A 40. The best interstate exit to take from A 45 is "Dortmund-Eichlinghofen" (closer to Campus Süd), and from B 1 / A 40 "Dortmund-Dorstfeld" (closer to Campus Nord). Signs for the university are located at both exits. Also, there is a new exit before you pass over the B 1-bridge leading into Dortmund.
To get from Campus Nord to Campus Süd by car, there is the connection via Vogelpothsweg/Baroper Straße. We recommend you leave your car on one of the parking lots at Campus Nord and use the H-Bahn (suspended monorail system), which conveniently connects the two campuses.
TU Dortmund University has its own train station ("Dortmund Universität"). From there, suburban trains (S-Bahn) leave for Dortmund main station ("Dortmund Hauptbahnhof") and Düsseldorf main station via the "Düsseldorf Airport Train Station" (take S-Bahn number 1, which leaves every 20 or 30 minutes). The university is easily reached from Bochum, Essen, Mülheim an der Ruhr and Duisburg.
You can also take the bus or subway train from Dortmund city to the university: From Dortmund main station, you can take any train bound for the Station "Stadtgarten", usually lines U41, U45, U 47 and U49. At "Stadtgarten" you switch trains and get on line U42 towards "Hombruch". Look out for the Station "An der Palmweide". From the bus stop just across the road, busses bound for TU Dortmund University leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dortmund main station to the stop "Dortmund Kampstraße". From there, take U43 or U44 to the stop "Dortmund Wittener Straße". Switch to bus line 447 and get off at "Dortmund Universität S".
The H-Bahn is one of the hallmarks of TU Dortmund University. There are two stations on Campus Nord. One ("Dortmund Universität S") is directly located at the suburban train stop, which connects the university directly with the city of Dortmund and the rest of the Ruhr Area. Also from this station, there are connections to the "Technologiepark" and (via Campus Süd) Eichlinghofen. The other station is located at the dining hall at Campus Nord and offers a direct connection to Campus Süd every five minutes.
The AirportExpress is a fast and convenient means of transport from Dortmund Airport (DTM) to Dortmund Central Station, taking you there in little more than 20 minutes. From Dortmund Central Station, you can continue to the university campus by interurban railway (S-Bahn). A larger range of international flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the university station.
The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent "Technologiepark".
Site Map of TU Dortmund University (Second Page in English).