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Cell Morphodynamics

Priv.-Doz. Dr. Leif Dehmelt

Technische Uni­ver­si­tät Dort­mund
Fakultät für Chemie und Chemische Biologie
Chemische Biologie
Otto-Hahn-Str. 4a
44227 Dort­mund 

Room: CP-02-157

E-Mail: leif.dehmelttu-dortmundde
Phone: +49 231 755 7057
Fax: +49 231 133 2299

Portrait Leif Dehmelt © Archiv​/​TU Dortmund

Team   CV


The development and function of multicellular organisms critically depends on dynamic changes in the shape of cells. Perturbations in the signal networks that control these changes can lead to developmental anomalies or cancer. In our research group, we investigate how the morphology and function of mammalian cells is controlled by such signal networks. We particularly focus on self-organizing pattern forming mechanisms that emerge from coupled reactions and diffusion of molecules inside individual cells [1-3]. To study these systems, we implement an interdisciplinary approach [1,4,5] that combines acute, microscopy-based experimental perturbations, the development of novel analysis technologies and theoretical investigations.

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Selected Publications

[1] Nanda S, Calderon A, Sachan A, Duong TT, Koch J, Xin X, Solouk-Stahlberg D, Wu YW, Nalbant P, Dehmelt L. (2023)
Rho GTPase activity crosstalk mediated by Arhgef11 and Arhgef12 coordinates cell protrusion-retraction cycles.
Nat Commun 14:8356

[2] Kamps D, Koch J, Juma VO, Campillo-Funollet E, Graessl M, Banerjee S, Mazel T, Chen X, Wu YW, Portet S, Madzvamuse A, Nalbant P, Dehmelt L, (2020).
Optogenetic Tuning Reveals Rho Amplification-Dependent Dynamics of a Cell Contraction Signal Network.
Cell Reports 33(9):108467

[3] Graessl M, Koch J, Calderon A, Kamps D, Banerjee S, Mazel T, Schulze N, Jungkurth JK, Patwardhan R, Solouk D, Hampe N, Hoffmann B, Dehmelt L, Nalbant P (2017).
An excitable Rho GTPase signaling network generates dynamic subcellular contraction patterns.
J Cell Biol 21(14):5311-6.

[4] Chen X, Venkatachalapathy M, Kamps D, Weigel S, Kumar R, Orlich M, Garrecht R, Hirtz M, Niemeyer CM, Wu YW, Dehmelt L. (2017).
Molecular-Activity Painting": Switch-like, Light-Controlled Perturbations inside Living Cells.
Angew Chem Int Ed Engl 21(14):5311-6.

[5] Gandor S, Reisewitz S, Venkatachalapathy M, Arrabito G, Reibner M, Schröder H, Ruf K, Niemeyer CM, Bastiaens PI, Dehmelt L (2013).
A protein-interaction array inside a living cell.
Angew Chem Int Ed Engl 52(18):4790-4.

More publications

We are always looking for talented co-workers and students who would like to join our lab. Please contact us via email if you are interested.