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Research Highlights

"Nonstatistical Assembly of Multicomponent [Pd2ABCD] Cages“
K. Wu, E. Benchimol, A. Baksi, G. H. Clever, Nat. Chem. 2024, accepted
(Highlighted in ChemistryViews, Chem, by Springer Nature and in a press release of TU Dort­mund)


"Photoswitchable Coordination Cages“
E. Benchimol, J. Tessarolo, G. H. Clever, Nat. Chem. 2024, accepted (Perspective Article)


"Guest-induced Reversible Transformation between an Azulene-based Pd2L4 Lantern-shaped Cage and a Pd4L8 Tetrahedron"
A. Walther, I. Regeni, J. J. Holstein, G. H. Clever,, J. Am. Chem. Soc. 2023, DOI: 10.1021/jacs.3c09295


"Structure and flexibility of copper-modified DNA G-quadruplexes investigated by 19F ENDOR at 34 GHz“
S. L. Schumann, S. Kotnig, Y. Kutin, M. Drosou, L. M. Stratmann, Y. Streltsova, A. Schnegg, D. A. Pantazis, G. H. Clever, M. Kasanmascheff, Chem. Eur. J. 2023, e202302527, DOI: 10.1002/chem.202302527

(In collaboration with JProf. Dr. Müge Kasan­mascheff)


"Engineering Soluble Diketopyrrolopyrrole Chromophore Stacks from a Series of Pd(II)-based Ravels“
I. Regeni, R. Chowdhury, K. Terlinden, S. Horiuchi, J. J. Holstein, S. Feldmann, G. H. Clever, Angew. Chem. Int. Ed. 2023, e202308288, DOI: 10.1002/anie.202308288


"Symmetry-breaking host–guest assembly in a hydrogen-bonded supramolecular system"
S. Horiuchi, T. Yamaguchi, J. Tessarolo, H. Tanaka, E. Sakuda, Y. Arikawa, E. Meggers, G. H. Clever, K. Umakoshi, Nat. Commun. 2023, 14, 155.


"Endohedrally Functionalized Heteroleptic Coordination Cages for Phosphate Ester Binding"
A. Platzek, S. Juber, C. Yurtseven, S. Hasegawa, L. Schneider, C. Drechsler, K. E. Ebbert, R. Rudolf, Q.-Q. Yan, J. J. Holstein, L. V. Schäfer, G. H. Clever, Angew. Chem. Int. Ed. 2022, DOI: 10.1002/anie.202209305.
(Hot Paper)


Guest-modulated Circularly Polarized Luminescence by Ligand-to-Ligand Chirality Transfer in Heteroleptic Pd(II) Coordination Cages
K. Wu, J. Tessarolo, A. Baksi, G. H. Clever, Angew. Chem. Int. Ed. 2022, DOI: 10.1002/anie.202205725.
(Hot Paper, Front Cover)


"Light-powered Dissipative Assembly of Diazocine Coordination Cages"
H. Lee, J. Tessarolo, D. Langbehn, A. Baksi, R. Herges, G. H. Clever, J. Am. Chem. Soc. 2022, 144, DOI: 10.1021/jacs.1c12011.

Official faculty news announcement with more information (German only)


"Cooperativity of steric bulk and H-bonding in coordination sphere engineering: heteroleptic PdII cages and bowls by de­sign"
B. Chen, J. J. Holstein, A. Platzek, L. Schneider, K. Wu, G. H. Clever, Chem. Sci. 2022, 13, 1829 - 1834.


"Coordination cage-based emulsifiers: templated formation of metal oxide microcapsules monitored by in situ LC-TEM"
S. Saha, Y.-T. Chen, S. Ganta, M. Gilles, B. Holzapfel, P. Lill, H. Rehage, C. Gatsogiannis, G. H. Clever, Chem. Eur. J. 2021, accepted.


"Long-Lived C60 Radical Anion Stabilized inside an Electron-Deficient Coordination Cage"
S. Hasegawa, S. L. Meichsner, J. J. Holstein, A. Baksi, M. Kasanmascheff, G. H. Clever, J. Am. Chem. Soc. 2021, 143, 9718.

(In collaboration with JProf. Dr. Müge Kasan­mascheff)


"Increasing Structural and Functional Complexity in Self-Assembled Coordination Cages"
S. Pullen, J. Tessarolo, G. H. Clever, Chem. Sci. 2021, 12, 7269-7293.


"Integrative Assembly of Heteroleptic Tetrahedra Con­trolled by Backbone Steric Bulk"
J. Tessarolo, H. Lee, E. Sakuda, K. Umakoshi, G. H. Clever, J. Am. Chem. Soc. 2021, 143, 6339.


"Thermodynamic Driving Forces of Guest Confinement in a Photoswitchable Cage"
S. Juber, S. Wingbermühle, P. Nuernberger, G. H. Clever, L. V. Schäfer, Phys. Chem. Chem. Phys. 2021, 23, 7321.


"Multinuclear Ag Clusters Sandwiched by Pt Complex Units: Fluxional Behavior and Chiral-at-Cluster Photoluminescence"
S. Horiuchi, S. Moon, A. Ito, J. Tessarolo, E. Sakuda, Y. Arikawa, G. H. Clever, K. Umakoshi, Angew. Chem. Int. Ed. 2021, 60, 10654.


"Modular Design of G-Quadruplex MetalloDNAzymes for Catalytic C-C Bond Formations with Switchable Enantioselectivity"
P. M. Punt, M. D. Langenberg, O. Altan, G. H. Clever, J. Am. Chem. Soc. 2021, 143, 3555.


"Multi-Stimuli Control over Assembly and Guest Binding in Metallo- Supramolecular Hosts based on DTE Photoswitches"
R. Li, J. Tessarolo, H. Lee, G. H. Clever, J. Am. Chem. Soc. 2021, 143, 3865.


"Identification of a Heteroleptic Pd6L6L’6 Coordination Cage by Screening of a Virtual Combinatorial Library"
S. Sudan, R. Li, S. Jansze, A. Platzek, R. Rudolf, G.  H. Clever, F. Fadaei Tirani, R. Scopelliti, K. Severin, J. Am. Chem. Soc. 2021, 143, 1773.

(in collaboration with Prof. Kay Severin from Ecole Polytechnique Fédérale de Lausanne - EPFL)


"Establishing electron diffraction in chemical crystallography"
T. Grüne, J. J. Holstein, G. H. Clever, B. Keppler, Nat. Rev. Chem. 2021, 5, 660-668.

Free access link

(Front Cover)

Highlighted in a press release of TU Dort­mund

 


"Coal-Tar Dye-based Coordination Cages and Helicates"
I. Regeni, B. Chen, M. Frank, A. Baksi, J. J. Holstein, G. H. Clever, Angew. Chem. Int. Ed. 2021, 60, 5673.

(Highlighted in a press release by the Cluster of Excellence RESOLV)

See video feature on TU Dortmund Youtube Channel


"Backbone-Bridging Promotes Diversity in Heteroleptic Cages"

K. Wu, B. Zhang, C. Drechsler, J. J. Holstein, G. H. Clever, Angew. Chem. Int. Ed. 2021, 60, 6403.


"Precise Distance Measurements in DNA G‐Quadruplex Dimers and Sandwich Complexes by Pulsed Dipolar EPR Spectroscopy"

L. M. Stratmann, Y. Kutin, M. Kasanmascheff, G. H. Clever, Angew. Chem. Int. Ed. 2021, 60, 4939.

(VIP Paper)

Highlighted in a press release of TU Dortmund, the Cluster of Excellence RESOLV, the ChemViews Magazine and by the Federal Ministry of Education and Research.

(In collaboration with JProf. Dr. Müge Kasanmascheff)


"A New Mechanically-Interlocked [Pd2L4] Cage Motif by Dimerization of two Peptide-based Lemniscates"

T. R. Schulte, J. J. Holstein, L. Schneider, A. Adam, G. Haberhauer, G. H. Clever, Angew. Chem. Int. Ed. 2020, 59, 22489.

(Hot Paper, Inside Cover)

(In collaboration with Prof. Gebhard Haberhauer from Duisburg-Essen University)


"Substrate and Product Binding inside a Stimuli-Responsive Coordination Cage acting as Singlet Oxygen Photosensitizer"

S. Pullen, S. Löffler, A. Platzek, J. J. Holstein, G. H. Clever, Dalton Trans. 2020, 49, 9404.


"Heteroleptic Coordination Environments in Metal-Mediated DNA G-Quadruplexes"

P. M. Punt, L. M. Stratmann, S. Sevim, L. Knauer, C. Strohmann, G. H. Clever, Front. Chem. 2020, 8, 26.


"Dynamic Complex-to-Complex Transformations of Heterobimetallic Systems Influence the Cage Structure or Spin State of Iron(II) Ions"

M. Hardy, N. Struch, J. J. Holstein, G. Schnakenburg, N. Wagner, M. Engeser, J. Beck, G. H. Clever, A. Lützen, Angew. Chem. Int. Ed. 2020, 59, 3195.


"Tunable Fullerene Affinity of Cages, Bowls and Rings Assembled by Pd(II) Coordination Sphere Engineering"

B. Chen, S. Horiuchi, J. J. Holstein, J. Tessarolo, G. H. Clever, Chem. Eur. J. 2019, 25, 14921.



"Resolution of Minor Size Differences in a Family of Heteroleptic Coordination Cages by Trapped Ion Mobility ESI-MS"

K. E. Ebbert, L. Schneider, A. Platzek, C. Drechsler, B. Chen, R. Rudolf, G. H. Clever, Dalton Trans. 201948, 11070.


"Pd(II) Coordination Sphere Engineering: Pyridine Cages, Quinoline Bowls and Heteroleptic Pills Binding One or Two Fullerenes"

B. Chen, J. J. Holstein, S. Horiuchi, W. G. Hiller, G. H. Clever, J. Am. Chem. Soc. 2019141, 8907.


"Successive Photoswitching and Derivatization Effects in Photochromic DTE-based Coordination Cages"

R. Li, M. Han, J. Tessarolo, J. J. Holstein, J. Lübben, B. Dittrich, C. Volkmann, M. Finze, C. Jenne, G. H. Clever, ChemPhotoChem 20193, 378.


"Chiral Self-Discrimination and Guest Recognition in Helicene-based Coordination Cages"

T. R. Schulte, J. J. Holstein, G. H. Clever, Angew. Chem. Int. Ed. 2019, 58, 5562.


"Mechanistic Interplay between Light-Switching and Guest-Binding in Photochromic [Pd2Dithienylethene4] Coordination Cages"

R. Li, J. J. Holstein, W. G. Hiller, J. Andréasson, G. H. Clever, J. Am. Chem. Soc. 2019141, 2097.


"Imidazole-modified G-quadruplex DNA as Metal-triggered Peroxidase"

P. M. Punt, G. H. Clever, Chem. Sci. 2019, 10, 2513.


"Rational Design of an Amphiphilic Coordination Cage-based Emulsifier"

S. Saha, B. Holzapfel, Y.-T. Chen, K. Terlinden, P. Lill, C. Gatsogiannis, H. Rehage, G. H. Clever, J. Am. Chem. Soc. 2018, 140, 17384.



"Rapid structure determination of microcrystalline molecular compounds using electron diffraction"

T. Gruene, J. T. C. Wennmacher, C. Zaubitzer, J. J. Holstein, J. Heidler, A. Fecteau-Lefebvre, S. De Carlo, E. Müller, K. N. Goldie, I. Regeni, T. Li, G. Santiso-Quinones, G. Steinfeld, S. Handschin, E. van Genderen, J. A. van Bokhoven, G. H. Clever, R. Pantelic, Angew. Chem. Int. Ed. 201857, 16313.

(Collaboration initiated by Dr. Tim Grüne, Paul Scherrer Institut, Switzerland, and Dr. Julian Holstein, head of crystallography in the Clever Lab)

“Electron diffraction was selected by Science Magazine as one out of twelve candidates worldwide for the research 2018 Breakthrough of the Year, and made the fifth rank in a public vote.”

Highlighted in c&enphys.orgScienceNews, NatureAngew. Chem. and Nature Chem.



"Donor-site-directed Rational Assembly of Heteroleptic cis-[Pd2L2L'2] Coordination Cages from Picolyl Ligands"

R. Zhu, W. M. Bloch, J. J. Holstein, S. Mandal, L. V. Schäfer, G. H. Clever, Chem. Eur. J. 201824, 12976.

(Hot Paper)


"Structure Relationships between Bis-monodentate Ligands and Coordination Driven Self-assemblies"

S. Saha, I. Regeni, G. H. Clever, Coord. Chem. Rev. 2018374, 1.


"Catenation and Aggregation of Multi-Cavity Coordination Cages"

R. Zhu, I. Regeni, J. J. Holstein, B. Dittrich, M. Simon, S. Prévost, M. Gradzielski, G. H. Clever, Angew. Chem. Int. Ed. 201857, 13652.

(VIP Paper, Front Cover)

Highlighted by Dr. Emiliano Feresin on the website of the RESOLV cluster of excellence.

Highlighted in the trend report 2019 on inorganic chemistry, published in the „Nachrichten aus der Chemie“, magazine of the German Chemical Society (GDCh).


"Di-Copper(II) DNA G-Quadruplexes as EPR Distance Rulers"

D. M. Engelhard, A. Meyer, A. Berndhäuser, O. Schiemann, G. H. Clever, Chem. Commun. 2018, 54, 7455.


"Hierarchical Assembly of an Interlocked M8L16 Container"

W. M. Bloch, J. J. Holstein, B. Dittrich, W. Hiller, G. H. Clever, Angew. Chem. Int. Ed201857, 5534.


"Structure-Property Relationships in CuII-binding Tetramolecular G-Quadruplex DNA"

D. M. Engelhard, L. M. Stratmann, G. H. Clever, Chem. Eur. J. 201824, 2117.

(Hot Paper, Cover Feature)


"Influence of Size, Shape, Heteroatom Content and Dispersive Contributions on Guest Binding in a Coordination Cage"

S. Löffler, A. Wuttke, B. Zhang, J. J. Holstein, R. A. Mata, G. H. Clever, Chem. Commun. 201753, 11933.



"Temperature-dependent Dynamics of Push-Pull Rotor Systems based on Acridinylidene Cyanoacetic Esters"

M. Krick, J. J. Holstein, A. Wuttke, R. A. Mata, G. H. Clever, Eur. J. Org. Chem. 20175141.


"Copper-induced Topology Switching and Thrombin Inhibition with Telomeric DNA G-Quadruplexes"

D. M. Engelhard, J. Nowack, G. H. Clever, Angew. Chem. Int. Ed. 201756, 11640.


"Integrative self-sorting of coordination cages based on 'naked' metal ions "

W. M. Bloch, G. H. Clever, Chem. Commun. 201753, 8506.


"Chiral-at-Metal Phosphorescent Square-Planar Pt(II)-Complexes from an Achiral Organometallic Ligand"

T. R. Schulte, J. J. Holstein, L. Krause, R. Michel, D. Stalke, E. Sakuda, K. Umakoshi, G. Longhi, S. Abbate, G. H. Clever, J. Am. Chem. Soc. 2017139, 6863.


"Morphological Control of Heteroleptic cis- and trans-Pd2L2L'2 Cages"

W. M. Bloch, J. J. Holstein, W. Hiller, G. H. Clever, Angew. Chem. Int. Ed. 201756, 8285.


"Geometric Complementarity in Assembly and Guest Recognition of a Bent Heteroleptic cis-[Pd2LA2LB2] Coordination Cage"

W. M. Bloch, Y. Abe, J. J. Holstein, C. M. Wandtke, B. Dittrich, G. H. Clever, J. Am. Chem. Soc. 2016138, 13750.


"Endohedral Dynamics of Push-Pull Rotor-functionalized Cages"

M. Krick, J. J. Holstein, C. Würtele, G. H. Clever, Chem. Commun. 201652, 10411.


"Desymmetrization of an Octahedral Coordination Complex inside a Self-Assembled Exoskeleton"

M. D. Johnstone; E. K. Schwarze; J. Ahrens; D. Schwarzer; J. J. Holstein; B. Dittrich; F. M. Pfeffer; G. H. Clever, Chem. Eur. J. 201622, 10791.


"Light-induced Charge Separation in Densely Packed Donor-Acceptor Coordination Cages"

M. Frank, J. Ahrens, I. Bejenke, M. Krick, D. Schwarzer, G. H. Clever, J. Am. Chem. Soc. 2016138, 8279.

Congratulations to Jennifer Ahrens (PhD student of collaboration partner Prof. Dirk Schwarzer, MPI for Biophysical Chemistry, Göttingen) for receiving a Poster Prize on the Bunsentagung 2016 for her contribution to our joint work. In addition, our work was featured on the cover of issue 5/2016 of the Bunsen Magazin.


"Interpenetrated Cage Structures"

M. Frank, M. D. Johnstone, G. H. Clever, Chem. Eur. J. 201622, 14104.

(Review, Hot Paper)


"Internal Dynamics and Guest Binding of a Sterically Overcrowded Host"

S. Löffler, J. Lübben, A. Wuttke, R. A. Mata, M. John, B. Dittrich, G. H. Clever, Chem. Sci. 20167, 4676.


"Light-controlled Interconversion between a Self-assembled Triangle and a Rhombicuboctahedral Sphere"

M. Han, Y. Luo, B. Damaschke, L. Go´mez, X. Ribas, A. Jose, P. Peretzki, M. Seibt, G. H. Clever, Angew. Chem. Int. Ed2016, 55, 445. (VIP Paper, Inside Cover)


"Triggered Exchange of Anionic for Neutral Guests inside a Cationic Coordination Cage"

S. Löffler, J. Lübben, L. Krause, D. Stalke, B. Dittrich, G. H. Clever, J. Am. Chem. Soc. 2015, 137, 1060.

Congratulations to Susanne Löffler for receiving a "MS-CEC Young Researcher Award 2016" for this paper from the Münster Symposium on Cooperative Effects in Chemistry!


"Modular synthesis of linear bis- and trismonodentate fused [6]polynorbornane-based ligands and their assembly into coordination cages"

M. D. Johnstone, E. K. Schwarze, G. H. Clever and F. M. Pfeffer, Chem. Eur. J. 2015, 21, 3948.

(Hot Paper, Inside Cover).


"Stepwise Halide-triggered Double- and Triple-Catenation of Self-Assembled Coordination Cages"

R. Zhu, J. Lübben, B. Dittrich, G. H. Clever, Angew. Chem. Int. Ed. 2015, 54, 2796.


"Rational Design of a Face-Centred Square-Cuboid Coordination Cage"

M. Han, R. Michel, G. H. Clever, Chem. Eur. J. 2014, 20, 10640.

(Special Issue: European Young Chemists).


"Self-Assembled Coordination Cages based on Banana-shaped Ligands"

M. Han, D. M. Engelhard, G. H. Clever, Chem. Soc. Rev. 2014, 43, 1848.

(Open Access article).


"Reversible Stabilization of Transition-Metal-Binding DNA G-Quadruplexes"

D. M. Engelhard, R. Pievo, G. H. Clever, Angew. Chem. Int. Ed. 2013, 52, 12843.


"Assembly and Stepwise Oxidation of Interpenetrated Coordination Cages based on Phenothiazine"

M. Frank, J. Hey, I. Balcioglu, Y.-S. Chen, D. Stalke, T. Suenobu, S. Fukuzumi, H. Frauendorf, G. H. Clever, Angew. Chem. Int. Ed. 2013, 52, 10102.


"Template Control over Dimerization and Guest Selectivity of Interpenetrated Coordination Cages"

S. Freye, R. Michel, D. Stalke, M. Pawliczek, H. Frauendorf, G. H. Clever, J. Am. Chem. Soc. 2013, 135, 8476.


"Stable and Metastable Self-Assembled Rings based on trans-chelated Pd(II)"

F. A. Pereira, T. Fallows, M. Frank, A. Chen, G. H. Clever, Z. Anorg. Allg. Chem. 2013, 639, 1598.


"Counter Ion Dynamics in an Interpenetrated Coordination Cage Capable of Dissolving AgCl"

S. Freye, D. M. Engelhard, M. John, G. H. Clever, Chem. Eur. J. 2013,19, 2114.


"Light-triggered Guest Uptake and Release by a Photochromic Coordination Cage"

M. Han, R. Michel, B. He, Y.-S. Chen, D. Stalke, M. John, G. H. Clever, Angew. Chem. Int. Ed. 2013, 52, 1319.

(Hot Paper)


"An Inclusion Complex of Hexamolybdate inside a Supramolecular Cage and its Structural Conversion"

M. Han, J. Hey, W. Kawamura, D. Stalke, M. Shionoya, G. H. Clever, Inorg. Chem. 2012, 51, 9574.

Highlighted in the ACS Virtual Issue on "Synthetic Inorganic Chemistry" 2013 and the ACS Inorganic Chemistry Virtual Issue on "Inorganic Cages and Containers" 2014.


"NMR-Based Structure Determination of an Intertwined Coordination Cage Resembling a Double Trefoil Knot"

D. M. Engelhard, S. Freye, K. Grohe, M. John, G. H. Clever, Angew. Chem. Int. Ed. 2012, 51, 4747.


"Allosteric Binding of Halide Anions by a New Dimeric Interpenetrated Coordination Cage"

S. Freye, J. Hey, A. Torras-Galán, D. Stalke, R. Herbst-Irmer, M. John, G. H. Clever, Angew. Chem. Int. Ed. 2012, 51, 2191.


"Stacked Platinum Complexes of the Magnus’ Salt Type Inside a Coordination Cage"

G. H. Clever, W. Kawamura, S. Tashiro, M. Shiro, M. Shionoya, Angew. Chem. Int. Ed. 2012, 51, 2606.

(Hot Paper, Inside Cover)