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Research Highlights

"Precise Distance Measurements in DNA G‐Quadruplex Dimers and Sandwich Complexes by Pulsed Dipolar EPR Spectroscopy"

L. M. Stratmann, Y. Kutin, M. Kasanmascheff, G. H. Clever, Angew. Chem. Int. Ed. 2020, accepted, DOI: 10.1002/anie.202008618

(VIP Paper)

(In collaboration with JProf. Dr. Müge Kasanmascheff)


"A New Mechanically-Interlocked [Pd2L4] Cage Motif by Dimerization of two Peptide-based Lemniscates"

T. R. Schulte, J. J. Holstein, L. Schneider, A. Adam, G. Haberhauer, G. H. Clever, Angew. Chem. Int. Ed. 2020, accepted, DOI: 10.1002/anie.202010995.

(Hot Paper, Inside Cover)

(In collaboration with Prof. Gebhard Haberhauer from Duisburg-Essen University)


"Substrate and Product Binding inside a Stimuli-Responsive Coordination Cage acting as Singlet Oxygen Photosensitizer"

S. Pullen, S. Löffler, A. Platzek, J. J. Holstein, G. H. Clever, Dalton Trans. 2020, 49, 9404.


"Heteroleptic Coordination Environments in Metal-Mediated DNA G-Quadruplexes"

P. M. Punt, L. M. Stratmann, S. Sevim, L. Knauer, C. Strohmann, G. H. Clever, Front. Chem. 2020, 8, 26.


"Dynamic Complex-to-Complex Transformations of Heterobimetallic Systems Influence the Cage Structure or Spin State of Iron(II) Ions"

M. Hardy, N. Struch, J. J. Holstein, G. Schnakenburg, N. Wagner, M. Engeser, J. Beck, G. H. Clever, A. Lützen, Angew. Chem. Int. Ed. 2020, 59, 3195.


"Tunable Fullerene Affinity of Cages, Bowls and Rings Assembled by Pd(II) Coordination Sphere Engineering"

B. Chen, S. Horiuchi, J. J. Holstein, J. Tessarolo, G. H. Clever, Chem. Eur. J. 2019, 25, 14921.



"Resolution of Minor Size Differences in a Family of Heteroleptic Coordination Cages by Trapped Ion Mobility ESI-MS"

K. E. Ebbert, L. Schneider, A. Platzek, C. Drechsler, B. Chen, R. Rudolf, G. H. Clever, Dalton Trans. 201948, 11070.


"Pd(II) Coordination Sphere Engineering: Pyridine Cages, Quinoline Bowls and Heteroleptic Pills Binding One or Two Fullerenes"

B. Chen, J. J. Holstein, S. Horiuchi, W. G. Hiller, G. H. Clever, J. Am. Chem. Soc. 2019141, 8907.


"Successive Photoswitching and Derivatization Effects in Photochromic DTE-based Coordination Cages"

R. Li, M. Han, J. Tessarolo, J. J. Holstein, J. Lübben, B. Dittrich, C. Volkmann, M. Finze, C. Jenne, G. H. Clever, ChemPhotoChem 20193, 378.


"Chiral Self-Discrimination and Guest Recognition in Helicene-based Coordination Cages"

T. R. Schulte, J. J. Holstein, G. H. Clever, Angew. Chem. Int. Ed. 2019, 58, 5562.


"Mechanistic Interplay between Light-Switching and Guest-Binding in Photochromic [Pd2Dithienylethene4] Coordination Cages"

R. Li, J. J. Holstein, W. G. Hiller, J. Andréasson, G. H. Clever, J. Am. Chem. Soc. 2019141, 2097.


"Imidazole-modified G-quadruplex DNA as Metal-triggered Peroxidase"

P. M. Punt, G. H. Clever, Chem. Sci. 2019, 10, 2513.


"Rational Design of an Amphiphilic Coordination Cage-based Emulsifier"

S. Saha, B. Holzapfel, Y.-T. Chen, K. Terlinden, P. Lill, C. Gatsogiannis, H. Rehage, G. H. Clever, J. Am. Chem. Soc. 2018, 140, 17384.



"Rapid structure determination of microcrystalline molecular compounds using electron diffraction"

T. Gruene, J. T. C. Wennmacher, C. Zaubitzer, J. J. Holstein, J. Heidler, A. Fecteau-Lefebvre, S. De Carlo, E. Müller, K. N. Goldie, I. Regeni, T. Li, G. Santiso-Quinones, G. Steinfeld, S. Handschin, E. van Genderen, J. A. van Bokhoven, G. H. Clever, R. Pantelic, Angew. Chem. Int. Ed. 201857, 16313.

(Collaboration initiated by Dr. Tim Grüne, Paul Scherrer Institut, Switzerland, and Dr. Julian Holstein, head of crystallography in the Clever Lab)

“Electron diffraction was selected by Science Magazine as one out of twelve candidates worldwide for the research 2018 Breakthrough of the Year, and made the fifth rank in a public vote.”

Highlighted in c&enphys.orgScienceNews, NatureAngew. Chem. and Nature Chem.



"Donor-site-directed Rational Assembly of Heteroleptic cis-[Pd2L2L'2] Coordination Cages from Picolyl Ligands"

R. Zhu, W. M. Bloch, J. J. Holstein, S. Mandal, L. V. Schäfer, G. H. Clever, Chem. Eur. J. 201824, 12976.

(Hot Paper)


"Structure Relationships between Bis-monodentate Ligands and Coordination Driven Self-assemblies"

S. Saha, I. Regeni, G. H. Clever, Coord. Chem. Rev. 2018374, 1.


"Catenation and Aggregation of Multi-Cavity Coordination Cages"

R. Zhu, I. Regeni, J. J. Holstein, B. Dittrich, M. Simon, S. Prévost, M. Gradzielski, G. H. Clever, Angew. Chem. Int. Ed. 201857, 13652.

(VIP Paper, Front Cover)

Highlighted by Dr. Emiliano Feresin on the website of the RESOLV cluster of excellence.

Highlighted in the trend report 2019 on inorganic chemistry, published in the „Nach­richten aus der Chemie“, magazine of the German Chemical Society (GDCh).


"Di-Copper(II) DNA G-Quadruplexes as EPR Distance Rulers"

D. M. Engelhard, A. Meyer, A. Berndhäuser, O. Schiemann, G. H. Clever, Chem. Commun. 2018, 54, 7455.


"Hierarchical Assembly of an Interlocked M8L16 Container"

W. M. Bloch, J. J. Holstein, B. Dittrich, W. Hiller, G. H. Clever, Angew. Chem. Int. Ed201857, 5534.


"Structure-Property Relationships in CuII-binding Tetramolecular G-Quadruplex DNA"

D. M. Engelhard, L. M. Stratmann, G. H. Clever, Chem. Eur. J. 201824, 2117.

(Hot Paper, Cover Feature)


"Influence of Size, Shape, Heteroatom Content and Dispersive Contributions on Guest Binding in a Coordination Cage"

S. Löffler, A. Wuttke, B. Zhang, J. J. Holstein, R. A. Mata, G. H. Clever, Chem. Commun. 201753, 11933.



"Temperature-dependent Dynamics of Push-Pull Rotor Systems based on Acridinylidene Cyanoacetic Esters"

M. Krick, J. J. Holstein, A. Wuttke, R. A. Mata, G. H. Clever, Eur. J. Org. Chem. 20175141.


"Copper-induced Topology Switching and Thrombin Inhibition with Telomeric DNA G-Quadruplexes"

D. M. Engelhard, J. Nowack, G. H. Clever, Angew. Chem. Int. Ed. 201756, 11640.


"Integrative self-sorting of coordination cages based on 'naked' metal ions "

W. M. Bloch, G. H. Clever, Chem. Commun. 201753, 8506.


"Chiral-at-Metal Phosphorescent Square-Planar Pt(II)-Complexes from an Achiral Organometallic Ligand"

T. R. Schulte, J. J. Holstein, L. Krause, R. Michel, D. Stalke, E. Sakuda, K. Umakoshi, G. Longhi, S. Abbate, G. H. Clever, J. Am. Chem. Soc. 2017139, 6863.


"Morphological Control of Heteroleptic cis- and trans-Pd2L2L'2 Cages"

W. M. Bloch, J. J. Holstein, W. Hiller, G. H. Clever, Angew. Chem. Int. Ed. 201756, 8285.


"Geometric Complementarity in Assembly and Guest Recognition of a Bent Heteroleptic cis-[Pd2LA2LB2] Coordination Cage"

W. M. Bloch, Y. Abe, J. J. Holstein, C. M. Wandtke, B. Dittrich, G. H. Clever, J. Am. Chem. Soc. 2016138, 13750.


"Endohedral Dynamics of Push-Pull Rotor-functionalized Cages"

M. Krick, J. J. Holstein, C. Würtele, G. H. Clever, Chem. Commun. 201652, 10411.


"Desymmetrization of an Octahedral Coordination Complex inside a Self-Assembled Exoskeleton"

M. D. Johnstone; E. K. Schwarze; J. Ahrens; D. Schwarzer; J. J. Holstein; B. Dittrich; F. M. Pfeffer; G. H. Clever, Chem. Eur. J. 201622, 10791.


"Light-induced Charge Separation in Densely Packed Donor-Acceptor Coordination Cages"

M. Frank, J. Ahrens, I. Bejenke, M. Krick, D. Schwarzer, G. H. Clever, J. Am. Chem. Soc. 2016138, 8279.

Congratulations to Jennifer Ahrens (PhD student of collaboration partner Prof. Dirk Schwarzer, MPI for Biophysical Chemistry, Göttingen) for receiving a Poster Prize on the Bunsentagung 2016 for her contribution to our joint work. In addition, our work was featured on the cover of issue 5/2016 of the Bunsen Magazin.


"Interpenetrated Cage Structures"

M. Frank, M. D. Johnstone, G. H. Clever, Chem. Eur. J. 201622, 14104.

(Review, Hot Paper)


"Internal Dynamics and Guest Binding of a Sterically Overcrowded Host"

S. Löffler, J. Lübben, A. Wuttke, R. A. Mata, M. John, B. Dittrich, G. H. Clever, Chem. Sci. 20167, 4676.


"Light-controlled Interconversion between a Self-assembled Triangle and a Rhombicuboctahedral Sphere"

M. Han, Y. Luo, B. Damaschke, L. Go´mez, X. Ribas, A. Jose, P. Peretzki, M. Seibt, G. H. Clever, Angew. Chem. Int. Ed2016, 55, 445. (VIP Paper, Inside Cover)


"Triggered Exchange of Anionic for Neutral Guests inside a Cationic Coordination Cage"

S. Löffler, J. Lübben, L. Krause, D. Stalke, B. Dittrich, G. H. Clever, J. Am. Chem. Soc. 2015, 137, 1060.

Congratulations to Susanne Löffler for receiving a "MS-CEC Young Researcher Award 2016" for this paper from the Münster Symposium on Cooperative Effects in Chemistry!


"Modular synthesis of linear bis- and trismonodentate fused [6]polynorbornane-based ligands and their assembly into coordination cages"

M. D. Johnstone, E. K. Schwarze, G. H. Clever and F. M. Pfeffer, Chem. Eur. J. 2015, 21, 3948.

(Hot Paper, Inside Cover).


"Stepwise Halide-triggered Double- and Triple-Catenation of Self-Assembled Coordination Cages"

R. Zhu, J. Lübben, B. Dittrich, G. H. Clever, Angew. Chem. Int. Ed. 2015, 54, 2796.


"Rational Design of a Face-Centred Square-Cuboid Coordination Cage"

M. Han, R. Michel, G. H. Clever, Chem. Eur. J. 2014, 20, 10640.

(Special Issue: European Young Chemists).


"Self-Assembled Coordination Cages based on Banana-shaped Ligands"

M. Han, D. M. Engelhard, G. H. Clever, Chem. Soc. Rev. 2014, 43, 1848.

(Open Access article).


"Reversible Stabilization of Transition-Metal-Binding DNA G-Quadruplexes"

D. M. Engelhard, R. Pievo, G. H. Clever, Angew. Chem. Int. Ed. 2013, 52, 12843.


"Assembly and Stepwise Oxidation of Interpenetrated Coordination Cages based on Phenothiazine"

M. Frank, J. Hey, I. Balcioglu, Y.-S. Chen, D. Stalke, T. Suenobu, S. Fukuzumi, H. Frauendorf, G. H. Clever, Angew. Chem. Int. Ed. 2013, 52, 10102.


"Template Control over Dimerization and Guest Selectivity of Interpenetrated Coordination Cages"

S. Freye, R. Michel, D. Stalke, M. Pawliczek, H. Frauendorf, G. H. Clever, J. Am. Chem. Soc. 2013, 135, 8476.


"Stable and Metastable Self-Assembled Rings based on trans-chelated Pd(II)"

F. A. Pereira, T. Fallows, M. Frank, A. Chen, G. H. Clever, Z. Anorg. Allg. Chem. 2013, 639, 1598.


"Counter Ion Dynamics in an Interpenetrated Coordination Cage Capable of Dissolving AgCl"

S. Freye, D. M. Engelhard, M. John, G. H. Clever, Chem. Eur. J. 2013,19, 2114.


"Light-triggered Guest Uptake and Release by a Photochromic Coordination Cage"

M. Han, R. Michel, B. He, Y.-S. Chen, D. Stalke, M. John, G. H. Clever, Angew. Chem. Int. Ed. 2013, 52, 1319.

(Hot Paper)


"An Inclusion Complex of Hexamolybdate inside a Supramolecular Cage and its Structural Conversion"

M. Han, J. Hey, W. Kawamura, D. Stalke, M. Shionoya, G. H. Clever, Inorg. Chem. 2012, 51, 9574.

Highlighted in the ACS Virtual Issue on "Synthetic Inorganic Chemistry" 2013 and the ACS Inorganic Chemistry Virtual Issue on "Inorganic Cages and Containers" 2014.


"NMR-Based Structure Determination of an Intertwined Coordination Cage Resembling a Double Trefoil Knot"

D. M. Engelhard, S. Freye, K. Grohe, M. John, G. H. Clever, Angew. Chem. Int. Ed. 2012, 51, 4747.


"Allosteric Binding of Halide Anions by a New Dimeric Interpenetrated Coordination Cage"

S. Freye, J. Hey, A. Torras-Galán, D. Stalke, R. Herbst-Irmer, M. John, G. H. Clever, Angew. Chem. Int. Ed. 2012, 51, 2191.


"Stacked Platinum Complexes of the Magnus’ Salt Type Inside a Coordination Cage"

G. H. Clever, W. Kawamura, S. Tashiro, M. Shiro, M. Shionoya, Angew. Chem. Int. Ed. 2012, 51, 2606.

(Hot Paper, Inside Cover)

Location & approach

The campus of TU Dort­mund University is located close to interstate junction Dort­mund West, where the Sauerlandlinie A 45 (Frankfurt-Dort­mund) crosses the Ruhrschnellweg B 1 / A 40. The best interstate exit to take from A 45 is "Dort­mund-Eichlinghofen" (closer to Campus Süd), and from B 1 / A 40 "Dort­mund-Dorstfeld" (closer to Campus Nord). Signs for the uni­ver­si­ty are located at both exits. Also, there is a new exit before you pass over the B 1-bridge leading into Dort­mund.

To get from Campus Nord to Campus Süd by car, there is the connection via Vogelpothsweg/Baroper Straße. We recommend you leave your car on one of the parking lots at Campus Nord and use the H-Bahn (suspended monorail system), which conveniently connects the two campuses.

TU Dort­mund University has its own train station ("Dort­mund Uni­ver­si­tät"). From there, suburban trains (S-Bahn) leave for Dort­mund main station ("Dort­mund Hauptbahnhof") and Düsseldorf main station via the "Düsseldorf Airport Train Station" (take S-Bahn number 1, which leaves every 20 or 30 minutes). The uni­ver­si­ty is easily reached from Bochum, Essen, Mülheim an der Ruhr and Duisburg.

You can also take the bus or subway train from Dort­mund city to the uni­ver­si­ty: From Dort­mund main station, you can take any train bound for the Station "Stadtgarten", usually lines U41, U45, U 47 and U49. At "Stadtgarten" you switch trains and get on line U42 towards "Hombruch". Look out for the Station "An der Palmweide". From the bus stop just across the road, busses bound for TU Dort­mund University leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dort­mund main station to the stop "Dort­mund Kampstraße". From there, take U43 or U44 to the stop "Dort­mund Wittener Straße". Switch to bus line 447 and get off at "Dort­mund Uni­ver­si­tät S".

The H-Bahn is one of the hallmarks of TU Dort­mund University. There are two stations on Campus Nord. One ("Dort­mund Uni­ver­si­tät S") is directly located at the suburban train stop, which connects the uni­ver­si­ty directly with the city of Dort­mund and the rest of the Ruhr Area. Also from this station, there are connections to the "Technologiepark" and (via Campus Süd) Eichlinghofen. The other station is located at the dining hall at Campus Nord and offers a direct connection to Campus Süd every five minutes.

The AirportExpress is a fast and convenient means of transport from Dort­mund Airport (DTM) to Dort­mund Central Station, taking you there in little more than 20 minutes. From Dort­mund Central Station, you can continue to the uni­ver­si­ty campus by interurban railway (S-Bahn). A larger range of in­ter­na­tio­nal flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the uni­ver­si­ty station.

The facilities of TU Dort­mund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the uni­ver­si­ty are located in the adjacent "Technologiepark".

Site Map of TU Dort­mund University (Second Page in English).