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ERC Consolidator Grant RAMSES

Reactivity and Assembly of Multifunctional, Stimuli-responsive Encapsulation Structures

Objectives

In biochemical systems, combinations of specialized molecular entities are precisely arranged in space to give highly complex architectures. Sophisticated functionality, such as the selective chemical transformation of substrates inside enzymes, emerges from the interplay of the individual components that are often grouped around a nanoscopic cavity. Furthermore, control mechanisms based on the cooperative binding of signal substances may regulate the enzyme’s action.

Grafic illustration © CleverLab​/​TU Dort­mund

Since the advent of supramolecular chemistry, sci­en­tists construct artificial systems with ever increasing complexity and functionality that promise to serve as the basis for future developments in bottom-up nanotechnology with applications in medicine (e.g. targeted drug delivery), smart diagnostics, catalysis, material science, molecular photonics, electronics and data processing.

Metal-mediated self-assembly is a mature technique to construct such discrete, nanosized objects. So far, however, the implementation of one type of organic ligand at a time is dominating the reported, highly symmetric structures, while the tailored integration of a set of different ligands requires sophisticated approaches to avoid narcissistic separation or formation of statistical libraries. 

Nature demonstrates that the key to the most sophisticated systems lies in multi-functionalized structures. To achieve this level of complexity with artificial systems, we develop multiple strategies for the synthesis of heteroleptic coordination architectures. As a result, different functional elements can be precisely arranged inside or outside the cavity and their interplay will be studied. Combined with our recent achievements in host-guest switching, we aim at adjustable receptors, controllable molecular reaction chambers and multifunctional photo/redox systems.

ERC RAMSES Publications

"Resolution of Minor Size Differences in a Family of Heteroleptic Coordination Cages by Trapped Ion Mobility ESI-MS"

K. E. Ebbert, L. Schneider, A. Platzek, C. Drechsler, B. Chen, R. Rudolf, G. H. Clever, Dalton Trans. 201948, 11070.

"Pd(II) Coordination Sphere Engineering: Pyridine Cages, Quinoline Bowls and Heteroleptic Pills Binding One or Two Fullerenes"

B. Chen, J. J. Holstein, S. Horiuchi, W. G. Hiller, G. H. Clever, J. Am. Chem. Soc. 2019141, 8907.

"Successive Photoswitching and Derivatization Effects in Photochromic DTE-based Coordination Cages"

R. Li, M. Han, J. Tessarolo, J. J. Holstein, J. Lübben, B. Dittrich, C. Volkmann, M. Finze, C. Jenne, G. H. Clever, ChemPhotoChem 20193, 378.

"Chiral Self-Discrimination and Guest Recognition in Helicene-based Coordination Cages"

T. R. Schulte, J. J. Holstein, G. H. Clever, Angew. Chem. Int. Ed. 2019, 58, 5562.

"Mechanistic Interplay between Light-Switching and Guest-Binding in Photochromic [Pd2Dithienylethene4] Coordination Cages"

R. Li, J. J. Holstein, W. G. Hiller, J. Andréasson, G. H. Clever, J. Am. Chem. Soc. 2019141, 2097.

"Rational Design of an Amphiphilic Coordination Cage-based Emulsifier"

S. Saha, B. Holzapfel, Y.-T. Chen, K. Terlinden, P. Lill, C. Gatsogiannis, H. Rehage, G. H. Clever, J. Am. Chem. Soc. 2018, 140, 17384.

"Donor-site-directed Rational Assembly of Heteroleptic cis-[Pd2L2L'2] Coordination Cages from Picolyl Ligands"

R. Zhu, W. M. Bloch, J. J. Holstein, S. Mandal, L. V. Schäfer, G. H. Clever, Chem. Eur. J. 201824, 12976.

(Hot Paper)

"Hierarchical Assembly of an Interlocked M8L16 Container"

W. M. Bloch, J. J. Holstein, B. Dittrich, W. Hiller, G. H. Clever, Angew. Chem. Int. Ed201857, 5534.

"Integrative self-sorting of coordination cages based on 'naked' metal ions "

W. M. Bloch, G. H. Clever, Chem. Commun. 201753, 8506.

"Morphological Control of Heteroleptic cis- and trans-Pd2L2L'2 Cages"

W. M. Bloch, J. J. Holstein, W. Hiller, G. H. Clever, Angew. Chem. Int. Ed. 201756, 8285.

"Geometric Complementarity in Assembly and Guest Recognition of a Bent Heteroleptic cis-[Pd2LA2LB2] Coordination Cage"

W. M. Bloch, Y. Abe, J. J. Holstein, C. M. Wandtke, B. Dittrich, G. H. Clever, J. Am. Chem. Soc. 2016138, 13750.

"Light-induced Charge Separation in Densely Packed Donor-Acceptor Coordination Cages"

M. Frank, J. Ahrens, I. Bejenke, M. Krick, D. Schwarzer, G. H. Clever, J. Am. Chem. Soc. 2016138, 8279.

Congratulations to Jennifer Ahrens (PhD student of collaboration partner Prof. Dirk Schwarzer, MPI for Biophysical Chemistry, Göttingen) for receiving a Poster Prize on the Bunsentagung 2016 for her contribution to our joint work. In addition, our work was featured on the cover of issue 5/2016 of the Bunsen Magazin.

Location & approach

The campus of TU Dort­mund University is located close to interstate junction Dort­mund West, where the Sauerlandlinie A 45 (Frankfurt-Dort­mund) crosses the Ruhrschnellweg B 1 / A 40. The best interstate exit to take from A 45 is "Dort­mund-Eichlinghofen" (closer to Campus Süd), and from B 1 / A 40 "Dort­mund-Dorstfeld" (closer to Campus Nord). Signs for the uni­ver­si­ty are located at both exits. Also, there is a new exit before you pass over the B 1-bridge leading into Dort­mund.

To get from Campus Nord to Campus Süd by car, there is the connection via Vogelpothsweg/Baroper Straße. We recommend you leave your car on one of the parking lots at Campus Nord and use the H-Bahn (suspended monorail system), which conveniently connects the two campuses.

TU Dort­mund University has its own train station ("Dort­mund Uni­ver­si­tät"). From there, suburban trains (S-Bahn) leave for Dort­mund main station ("Dort­mund Hauptbahnhof") and Düsseldorf main station via the "Düsseldorf Airport Train Station" (take S-Bahn number 1, which leaves every 20 or 30 minutes). The uni­ver­si­ty is easily reached from Bochum, Essen, Mülheim an der Ruhr and Duisburg.

You can also take the bus or subway train from Dort­mund city to the uni­ver­si­ty: From Dort­mund main station, you can take any train bound for the Station "Stadtgarten", usually lines U41, U45, U 47 and U49. At "Stadtgarten" you switch trains and get on line U42 towards "Hombruch". Look out for the Station "An der Palmweide". From the bus stop just across the road, busses bound for TU Dort­mund University leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dort­mund main station to the stop "Dort­mund Kampstraße". From there, take U43 or U44 to the stop "Dort­mund Wittener Straße". Switch to bus line 447 and get off at "Dort­mund Uni­ver­si­tät S".

The H-Bahn is one of the hallmarks of TU Dort­mund University. There are two stations on Campus Nord. One ("Dort­mund Uni­ver­si­tät S") is directly located at the suburban train stop, which connects the uni­ver­si­ty directly with the city of Dort­mund and the rest of the Ruhr Area. Also from this station, there are connections to the "Technologiepark" and (via Campus Süd) Eichlinghofen. The other station is located at the dining hall at Campus Nord and offers a direct connection to Campus Süd every five minutes.

The AirportExpress is a fast and convenient means of transport from Dort­mund Airport (DTM) to Dort­mund Central Station, taking you there in little more than 20 minutes. From Dort­mund Central Station, you can continue to the uni­ver­si­ty campus by interurban railway (S-Bahn). A larger range of in­ter­na­tio­nal flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the uni­ver­si­ty station.

The facilities of TU Dort­mund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the uni­ver­si­ty are located in the adjacent "Technologiepark".

Site Map of TU Dort­mund University (Second Page in English).