ERC Consolidator Grant RAMSES
Reactivity and Assembly of Multifunctional, Stimuli-responsive Encapsulation Structures
In biochemical systems, combinations of specialized molecular entities are precisely arranged in space to give highly complex architectures. Sophisticated functionality, such as the selective chemical transformation of substrates inside enzymes, emerges from the interplay of the individual components that are often grouped around a nanoscopic cavity. Furthermore, control mechanisms based on the cooperative binding of signal substances may regulate the enzyme’s action.
Since the advent of supramolecular chemistry, scientists construct artificial systems with ever increasing complexity and functionality that promise to serve as the basis for future developments in bottom-up nanotechnology with applications in medicine (e.g. targeted drug delivery), smart diagnostics, catalysis, material science, molecular photonics, electronics and data processing.
Metal-mediated self-assembly is a mature technique to construct such discrete, nanosized objects. So far, however, the implementation of one type of organic ligand at a time is dominating the reported, highly symmetric structures, while the tailored integration of a set of different ligands requires sophisticated approaches to avoid narcissistic separation or formation of statistical libraries.
Nature demonstrates that the key to the most sophisticated systems lies in multi-functionalized structures. To achieve this level of complexity with artificial systems, we develop multiple strategies for the synthesis of heteroleptic coordination architectures. As a result, different functional elements can be precisely arranged inside or outside the cavity and their interplay will be studied. Combined with our recent achievements in host-guest switching, we aim at adjustable receptors, controllable molecular reaction chambers and multifunctional photo/redox systems.
ERC RAMSES Publications
Modular Enhancement of Circularly Polarized Luminescence in Pd2A2B2 heteroleptic cages
J. Tessarolo, E. Benchimol, A. Jouaiti, M. Wais Hosseini, G. H. Clever, Chem. Commun. 2023, DOI: 10.1039/D3CC00262D
"Endohedrally Functionalized Heteroleptic Coordination Cages for Phosphate Ester Binding"
A. Platzek, S. Juber, C. Yurtseven, S. Hasegawa, L. Schneider, C. Drechsler, K. E. Ebbert, R. Rudolf, Q.-Q. Yan, J. J. Holstein, L. V. Schäfer, G. H. Clever, Angew. Chem. Int. Ed. 2022, DOI: 10.1002/anie.202209305.
"Photoinduced Host-to-Guest Electron Transfer in a Self-Assembled Coordination Cage"
S. Ganta, J.-H. Borter, C. Drechsler, J. J. Holstein, D. Schwarzer, G. H. Clever, Org. Chem. Front. 2022, 9, 5485-5493.
Guest-modulated Circularly Polarized Luminescence by Ligand-to-Ligand Chirality Transfer in Heteroleptic Pd(II) Coordination Cages
K. Wu, J. Tessarolo, A. Baksi, G. H. Clever, Angew. Chem. Int. Ed. 2022, DOI: 10.1002/anie.202205725.
(Hot Paper, Front Cover)
"Nonaqueous Emulsion Polycondensation enabled by a Self-Assembled Cage-like Surfactant"
S. Ganta, C. Drechsler, Y.-T. Chen, G. H. Clever, Chem. Eur. J. 2022, 28, e202104228.
"Coordination cage-based emulsifiers: templated formation of metal oxide microcapsules monitored by in situ LC-TEM"
S. Saha, Y.-T. Chen, S. Ganta, M. Gilles, B. Holzapfel, P. Lill, H. Rehage, C. Gatsogiannis, G. H. Clever, Chem. Eur. J. 2021, accepted.
"Cooperativity of steric bulk and H-bonding in coordination sphere engineering: heteroleptic PdII cages and bowls by design"
B. Chen, J. J. Holstein, A. Platzek, L. Schneider, K. Wu, G. H. Clever, Chem. Sci. 2022, 13, 1829 - 1834.
"Light-powered Dissipative Assembly of Diazocine Coordination Cages"
H. Lee, J. Tessarolo, D. Langbehn, A. Baksi, R. Herges, G. H. Clever, J. Am. Chem. Soc. 2022, 144, DOI: 10.1021/jacs.1c12011.
Official faculty news announcement with more information (German only)
"A Family of Heterobimetallic Cubes Shows Spin-Crossover Behaviour Near Room Temperature"
M. Hardy, J. Tessarolo, J. J. Holstein, N. Struch, N. Wagner, R. Weisbarth, M. Engeser, J. Beck, S. Horiuchi, G. H. Clever, A. Lützen, Angew. Chem. Int. Ed. 2021, 60, 22562-22569.
"Integrative Assembly of Heteroleptic Tetrahedra Controlled by Backbone Steric Bulk"
J. Tessarolo, H. Lee, E. Sakuda, K. Umakoshi, G. H. Clever, J. Am. Chem. Soc. 2021, 143, 6339.
"Increasing Structural and Functional Complexity in Self-Assembled Coordination Cages"
S. Pullen, J. Tessarolo, G. H. Clever, Chem. Sci. 2021, 12, 7269-7293.
"Multi-Stimuli Control over Assembly and Guest Binding in Metallo- Supramolecular Hosts based on DTE Photoswitches"
R. Li, J. Tessarolo, H. Lee, G. H. Clever, J. Am. Chem. Soc. 2021, 143, 3865.
"Coal-Tar Dye-based Coordination Cages and Helicates"
I. Regeni, B. Chen, M. Frank, A. Baksi, J. J. Holstein, G. H. Clever, Angew. Chem. Int. Ed. 2021, 60, 5673.
(Highlighted in a press release by the Cluster of Excellence RESOLV)
"Backbone-Bridging Promotes Diversity in Heteroleptic Cages"
K. Wu, B. Zhang, C. Drechsler, J. J. Holstein, G. H. Clever, Angew. Chem. Int. Ed. 2021, 60, 6403.
"Dynamic Complex-to-Complex Transformations of Heterobimetallic Systems Influence the Cage Structure or Spin State of Iron(II) Ions"
M. Hardy, N. Struch, J. J. Holstein, G. Schnakenburg, N. Wagner, M. Engeser, J. Beck, G. H. Clever, A. Lützen, Angew. Chem. Int. Ed. 2020, 59, 3195.
"A New Mechanically-Interlocked [Pd2L4] Cage Motif by Dimerization of two Peptide-based Lemniscates"
T. R. Schulte, J. J. Holstein, L. Schneider, A. Adam, G. Haberhauer, G. H. Clever, Angew. Chem. Int. Ed. 2020, 59, 22489.
(Hot Paper, Inside Cover)
(In collaboration with Prof. Gebhard Haberhauer from Duisburg-Essen University)
"Heteroleptic Coordination Environments in Metal-Mediated DNA G-Quadruplexes"
P. M. Punt, L. M. Stratmann, S. Sevim, L. Knauer, C. Strohmann, G. H. Clever, Front. Chem. 2020, 8, 26.
"Tunable Fullerene Affinity of Cages, Bowls and Rings Assembled by Pd(II) Coordination Sphere Engineering"
B. Chen, S. Horiuchi, J. J. Holstein, J. Tessarolo, G. H. Clever, Chem. Eur. J. 2019, 25, 14921.
"Resolution of Minor Size Differences in a Family of Heteroleptic Coordination Cages by Trapped Ion Mobility ESI-MS"
K. E. Ebbert, L. Schneider, A. Platzek, C. Drechsler, B. Chen, R. Rudolf, G. H. Clever, Dalton Trans. 2019, 48, 11070.
"Pd(II) Coordination Sphere Engineering: Pyridine Cages, Quinoline Bowls and Heteroleptic Pills Binding One or Two Fullerenes"
B. Chen, J. J. Holstein, S. Horiuchi, W. G. Hiller, G. H. Clever, J. Am. Chem. Soc. 2019, 141, 8907.
"Successive Photoswitching and Derivatization Effects in Photochromic DTE-based Coordination Cages"
R. Li, M. Han, J. Tessarolo, J. J. Holstein, J. Lübben, B. Dittrich, C. Volkmann, M. Finze, C. Jenne, G. H. Clever, ChemPhotoChem 2019, 3, 378.
"Chiral Self-Discrimination and Guest Recognition in Helicene-based Coordination Cages"
T. R. Schulte, J. J. Holstein, G. H. Clever, Angew. Chem. Int. Ed. 2019, 58, 5562.
"Mechanistic Interplay between Light-Switching and Guest-Binding in Photochromic [Pd2Dithienylethene4] Coordination Cages"
R. Li, J. J. Holstein, W. G. Hiller, J. Andréasson, G. H. Clever, J. Am. Chem. Soc. 2019, 141, 2097.
"Rational Design of an Amphiphilic Coordination Cage-based Emulsifier"
S. Saha, B. Holzapfel, Y.-T. Chen, K. Terlinden, P. Lill, C. Gatsogiannis, H. Rehage, G. H. Clever, J. Am. Chem. Soc. 2018, 140, 17384.
"Mixed-Ligand Metal-Organic Frameworks and Heteroleptic Coordination Cages as Multifunctional Scaffolds – A Comparison"
S. Pullen, G. H. Clever, Acc. Chem. Res. 2018, 51, 3052.
"Donor-site-directed Rational Assembly of Heteroleptic cis-[Pd2L2L'2] Coordination Cages from Picolyl Ligands"
R. Zhu, W. M. Bloch, J. J. Holstein, S. Mandal, L. V. Schäfer, G. H. Clever, Chem. Eur. J. 2018, 24, 12976.
"Hierarchical Assembly of an Interlocked M8L16 Container"
W. M. Bloch, J. J. Holstein, B. Dittrich, W. Hiller, G. H. Clever, Angew. Chem. Int. Ed. 2018, 57, 5534.
"Integrative self-sorting of coordination cages based on 'naked' metal ions "
W. M. Bloch, G. H. Clever, Chem. Commun. 2017, 53, 8506.
"Morphological Control of Heteroleptic cis- and trans-Pd2L2L'2 Cages"
W. M. Bloch, J. J. Holstein, W. Hiller, G. H. Clever, Angew. Chem. Int. Ed. 2017, 56, 8285.
"Geometric Complementarity in Assembly and Guest Recognition of a Bent Heteroleptic cis-[Pd2LA2LB2] Coordination Cage"
W. M. Bloch, Y. Abe, J. J. Holstein, C. M. Wandtke, B. Dittrich, G. H. Clever, J. Am. Chem. Soc. 2016, 138, 13750.
"Light-induced Charge Separation in Densely Packed Donor-Acceptor Coordination Cages"
M. Frank, J. Ahrens, I. Bejenke, M. Krick, D. Schwarzer, G. H. Clever, J. Am. Chem. Soc. 2016, 138, 8279.
Congratulations to Jennifer Ahrens (PhD student of collaboration partner Prof. Dirk Schwarzer, MPI for Biophysical Chemistry, Göttingen) for receiving a Poster Prize on the Bunsentagung 2016 for her contribution to our joint work. In addition, our work was featured on the cover of issue 5/2016 of the Bunsen Magazin.
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Location & approach
The campus of TU Dortmund University is located close to interstate junction Dortmund West, where the Sauerlandlinie A 45 (Frankfurt-Dortmund) crosses the Ruhrschnellweg B 1 / A 40. The best interstate exit to take from A 45 is "Dortmund-Eichlinghofen" (closer to Campus Süd), and from B 1 / A 40 "Dortmund-Dorstfeld" (closer to Campus Nord). Signs for the university are located at both exits. Also, there is a new exit before you pass over the B 1-bridge leading into Dortmund.
To get from Campus Nord to Campus Süd by car, there is the connection via Vogelpothsweg/Baroper Straße. We recommend you leave your car on one of the parking lots at Campus Nord and use the H-Bahn (suspended monorail system), which conveniently connects the two campuses.
TU Dortmund University has its own train station ("Dortmund Universität"). From there, suburban trains (S-Bahn) leave for Dortmund main station ("Dortmund Hauptbahnhof") and Düsseldorf main station via the "Düsseldorf Airport Train Station" (take S-Bahn number 1, which leaves every 20 or 30 minutes). The university is easily reached from Bochum, Essen, Mülheim an der Ruhr and Duisburg.
You can also take the bus or subway train from Dortmund city to the university: From Dortmund main station, you can take any train bound for the Station "Stadtgarten", usually lines U41, U45, U 47 and U49. At "Stadtgarten" you switch trains and get on line U42 towards "Hombruch". Look out for the Station "An der Palmweide". From the bus stop just across the road, busses bound for TU Dortmund University leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dortmund main station to the stop "Dortmund Kampstraße". From there, take U43 or U44 to the stop "Dortmund Wittener Straße". Switch to bus line 447 and get off at "Dortmund Universität S".
The H-Bahn is one of the hallmarks of TU Dortmund University. There are two stations on Campus Nord. One ("Dortmund Universität S") is directly located at the suburban train stop, which connects the university directly with the city of Dortmund and the rest of the Ruhr Area. Also from this station, there are connections to the "Technologiepark" and (via Campus Süd) Eichlinghofen. The other station is located at the dining hall at Campus Nord and offers a direct connection to Campus Süd every five minutes.
The AirportExpress is a fast and convenient means of transport from Dortmund Airport (DTM) to Dortmund Central Station, taking you there in little more than 20 minutes. From Dortmund Central Station, you can continue to the university campus by interurban railway (S-Bahn). A larger range of international flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the university station.
The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent "Technologiepark".
Site Map of TU Dortmund University (Second Page in English).