To content

Publications

* corresponding author

2023

21. V. Wycisk*, M.-C. Wagner, L.H. Urner*
Trends in the Diversification of the Detergentome
ChemPlusChem, 2023, e202300386, doi.org/10.1002/cplu.202300386
Cover art invited and sponsored by ChemPlusChem

20. C.A. Lutomski, T.J. El-Baba, J.D. Hinkle, I. Liko, J.L. Bennett, N.V. Kalmankar, A. Dolan, C. Kirschbaum, K. Greis, L.H. Urner, P. Kapoor, H.-Y. Yen, K. Pagel, C. Mullen, J.E.P. Syka, C.V. Robinson*Infrared Multiphoton Dissociation Enables Top-Down Characterization of Membrane Protein Complexes and G Protein-Coupled Receptors
Angew. Chem. Int. Ed., 2023, e202305694, doi.org/10.1002/ange.202305694

19.   L.H. Urner*, F. Junge, F. Fiorentino, T.J. El-Baba, D. Shutin, G. Nölte, R. Haag, C.V. Robinson*
Rationalizing the optimization of detergents for membrane protein purification
Chem. Eur. J., 2023, e202300159, doi.org/10.1002/chem.202300159

18.   V. Wycisk, L.H. Urner*
Protocol to test the utility of detergents for E. coli membrane protein extraction and delipidation
STAR Protoc., 2023, 4, 1-18, doi.org/10.1016/j.xpro.2023.102146

17.   J.-S. Behnke, L.H. Urner*
Emergence of mass spectrometry detergents for membrane proteomics
Anal. Bioanal. Chem., 2023, doi.org/10.1007/s00216-023-04584-z
Invited paper in the special issue: Young Investigators in (Bio-)Analytical Chemistry 2023

2022

16.    L.H. Urner*, A. Ariamajd, A. Weikum
Combinatorial synthesis enables scalable designer detergents for membrane protein studies
Chem. Sci., 2022, doi.org/10.1039/D2SC03130B
Related press release from TU Dortmund University

15.   L.H. Urner*
Tailoring Purification and Analysis of Membrane Proteins with Modular Detergents
Methods in Molecular Biology, 2022, In: Mus-Veteau, I. (eds) Heterologous Expression of Membrane Proteins. Methods in Molecular Biology, vol 2507. Humana, New York, NY. doi.org/10.1007/978-1-0716-2368-8_19

14.   L.H. Urner*
Advances in membrane mimetics and mass spectrometry for understanding membrane structure and function
Curr. Opin. Chem. Biol., 2022, 69, 102157

13.   L.H.Urner*, I. Liko, K. Pagel, R. Haag, C.V. Robinson
Non-ionic hybrid detergents for protein delipidation
BBA Biomembranes, 2022, 183958
Invited paper in the special issue: Protons at bio-interfaces

2019 - 2021

12.   L.H. Urner*, E. Mohammadifar, K. Ludwig, D. Shutin, F. Fiorentino, I. Liko, F.G. Almeida, D. Kutifa, R. Haag, C.V. Robinson*
Anionic dendritic polyglycerol for protein purification and delipidation
ACS Appl. Polym. Mater. 2021, 3, 5903-5911

11. M. Agasid, L. Sørensen, L.H. Urner, J. Yun, C.V. Robinson*
The effect of sodium ions on ligand binding and conformational states of GPCRs – insights from mass spectrometry
 J. Am. Chem. Soc., 2021, 143, 4085-4089

10. L.H. Urner*, K. Goltsche, M, Seelent, M.-P. Schweder, I. Liko, C.V. Robinson, K. Pagel, R. Haag
Dendritic oligoglycerol regioisomer mixtures and their utility for membrane protein research
Chem. Eur. J., 2021, 27, 2537-2542

9. L.H. Urner*, M. Schulze, Y.B. Maier, W. Hoffmann, S. Warnke, I. Liko, K. Folmert, C. Manz, C.V. Robinson, R. Haag, K. Pagel*
A new azobenzene-based design strategy for detergents in membrane protein research
Chem. Sci., 2020, 11, 3538-3546

8. L.H. Urner, I. Liko, H.-Y. Yen, K.-K. Hoi, J.R. Bolla, J. Gault, F.G. Almeida, M.-P. Schweder, D. Shutin, S. Ehrmann, R. Haag*, C.V. Robinson*, K. Pagel*
Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors
Nat. Commun., 2020, 11, 564

7. L.H. Urner*, B. Schade, M. Schulze, K. Folmert, R. Haag, K. Pagel
Switchable solubility of azobenzene‐based bolaamphiphiles
ChemPhysChem, 2019, 20, 1690-1697

6. L.H. Urner, Y.B. Maier, R. Haag, K. Pagel*
Exploring the potential of dendritic oligoglycerol detergents for protein mass spectrometry
 J. Am. Soc. Mass Spectrom., 2019, 30, 174-180

2014 - 2018

5. H.V. Schröder, A. Mekic, H. Hupatz, S. Sobottka, F. Witte, L.H. Urner, M. Gaedke, K. Pagel, B. Sarkar, B. Paulus, C.A. Schalley*
Switchable synchronisation of pirouetting motions in a redox-active [3]rotaxane
Nanoscale, 2018, 10, 21425-21433

4. K. Huth, T. Heek, K. Achazi, C. Kuehne, L.H. Urner, K. Pagel, J. Dernedde, R. Haag*
Noncharged and charged monodendronised perylene bisimides as highly fluorescent labels and their bioconjugates
Chem. Eur. J., 2017, 23, 4849-4862

3. B.N.S. Thota*, L.H. Urner, R. Haag
Supramolecular architectures of dendritic amphiphiles in water
Chem. Rev., 2016, 116, 2079-2102

2. L.H. Urner, B.N.S. Thota, O. Nachtigall, S. Warnke, G. von Helden, R. Haag, K. Pagel*
Online monitoring the isomerization of an azobenzene-based dendritic bolaamphiphile using ion mobility-mass spectrometry
Chem. Commun., 2015, 51, 8801-8804

1. O. Nachtigall, C. Kördel, L.H. Urner, R. Haag*
Photoresponsive switches at surfaces based on supramolecular functionalization with azobenzene-oligoglycerol conjugates
Angew. Chem. Int. Ed., 2014, 53, 9669-9673

Patent Applications

L.H. Urner, F. Fiorentino, M. Agasid, D. Shutin, K. Pagel, R. Haag, C.V. Robinson
Hybrid detergents for the analysis of membrane proteins
UK patent application no. 2106700.4, filed: 11.05.2021

L.H. Urner, K. Pagel, S. Ehrmann, C.V. Robinson, I. Liko, H.-Y. Yen
Dendritic detergents for the analysis of proteins by mass spectrometry
UK patent application no. 1814356.0, WO2020/049294, filed: 04.09.2018

Highlighted References

New detergents for drug research
TU Dortmund University, published: 2022

The State of NRW Funding a New Junior Research Group at TU Dortmund University
TU Dortmund University, published: 2022

Modulare Detergenzien für GPCRs & Co
Wiley Analytical Science, published: 2021

Waschen und Wiegen für neue Wirkstoffe
vfa.bio, Die forschenden Pharma-Unternehmen, published: 2020

Tipp 227: Neue Putzmittel für Membranproteine, Laborjournal
Laborjournal, published: 2020

Tree-like Detergent Molecules for Membrane Proteins
Freie Universität Berlin, published: 2020

“Trans Pro Idee”-Kurs ausgezeichnet: Forschungsideen erfolgreich umsetzen
Tagesspiegel, published: 2015