Publications

* corresponding author

30.   J.S. Behnke, A. Hentschel, M. Wolf, V. Wycisk, A. Sickmann*, R.S. Heyer*, L.H. Urner*
Detergent Screening with Hybrid Detergents Increases Observable Number of Protein Identities in Bottom-Up Proteomics
Proteomics, 2025, e70003, doi.org/10.1002/pmic.70003

29.   K. Alker, J.-S. Behnke, L.H. Urner*
Recent Advances in Detergent Chemistry and Handling Support Membrane Protein Analysis including Lipid Interactions
Chem. Eur. J. 2025, e202501549, doi.org/10.1002/chem.202501549

28. A.K. Singh*, M. Seewald, B. Schade, C. Zoister, R. Haag, L.H. Urner*
Chemical linkers switch triglycerol detergents from bacterial protein purification to mild antibiotic amplification
Commun. Chem. 2025, 8, 70, doi.org/10.1038/s42004-025-01477-3

27. J.-S. Behnke *, N. Zink, C.J.M. Schölzel, I. Beimdick, L.H. Urner, V. Wycisk*
Combining Ionic Groups with Methallyl Dichloride Coupling Delivers New Pathways to Ionic/Non-Ionic Hybrid Detergents
ChemPlusChem, 2025, e202400753, doi.org/10.1002/cplu.202400753

26.   L. Nielinger, K. Alker, W. Hiller, L.H. Urner*
Diffusion Coefficient Analysis by Dynamic Light Scattering enables Determination of Critical Micelle Concentration
ChemPlusChem, 2024, e202400645, doi.org/10.1002/cplu.202400645
Poster Prize: Division of Detergent Chemistry Award (GDCh)

25. K. Kirschbaum*, K. Greis, S. Gewinner, W. Schöllkopf, G. Meijer, G. von Helden, K. Pagel, L.H. Urner*
Structure and Conformation Determine Gas-Phase Infrared Spectra of Detergents
ChemPlusChem, 2024, e202400340, doi.org/10.1002/cplu.202400340

24. V. Wycisk*, J.-S. Behnke, L. Nielinger, M. Seewald, J. Weisner, M. Binsch, M.-C. Wagner, T. Raisch, L.H. Urner*
Synthesis of Asymmetric Ionic Hybrid Detergents enables Micelles with Scalable Properties including Cell Compatibility
Chem. Eur. J., 2024, e202401833,  doi.org/10.1002/chem.202401833

23.   M. Seewald, L. Nielinger, K. Alker, J.-S. Behnke, V. Wycisk, L.H. Urner*
Detergent Chemistry Modulates the Transgression of Planetary Boundaries including Antimicrobial Resistance and Drug Discovery
Angew. Chem. Int. Ed., 2024, 63, e202403833, doi.org/10.1002/ange.202403833
Interview: Three questions to L.H. Urner asked by Humboldtⁿ

22.   L.H. Urner*, F. Fiorentino, D. Shutin, J.B. Sauer, M.T. Agasid, T.J. El-Baba, J.R. Bolla, P.J. Stansfeld, C.V. Robinson*
Detergents with Scalable Properties Identify Noncanonical Lipopolysaccharide Binding to Bacterial Inner Membrane Proteins
J. Am. Chem. Soc., 2024,146, 11025-11030, doi.org/10.1021/jacs.3c14358
Press release: TU Dortmund University
Feature article: Wiley Analytical Science

21. V. Wycisk*, M.-C. Wagner, L.H. Urner*
Trends in the Diversification of the Detergentome
ChemPlusChem, 2023, e202300386, doi.org/10.1002/cplu.202300386
Cover art invited and sponsored by ChemPlusChem

20. C.A. Lutomski, T.J. El-Baba, J.D. Hinkle, I. Liko, J.L. Bennett, N.V. Kalmankar, A. Dolan, C. Kirschbaum, K. Greis, L.H. Urner, P. Kapoor, H.-Y. Yen, K. Pagel, C. Mullen, J.E.P. Syka, C.V. Robinson*
Infrared Multiphoton Dissociation Enables Top-Down Characterization of Membrane Protein Complexes and G Protein-Coupled Receptors
Angew. Chem. Int. Ed., 2023, e202305694, doi.org/10.1002/ange.202305694

19.   L.H. Urner*, F. Junge, F. Fiorentino, T.J. El-Baba, D. Shutin, G. Nölte, R. Haag, C.V. Robinson*
Rationalizing the optimization of detergents for membrane protein purification
Chem. Eur. J., 2023, e202300159, doi.org/10.1002/chem.202300159

18.   V. Wycisk, L.H. Urner*
Protocol to test the utility of detergents for E. coli membrane protein extraction and delipidation
STAR Protoc., 2023, 4, 1-18, doi.org/10.1016/j.xpro.2023.102146

17.   J.-S. Behnke, L.H. Urner*
Emergence of mass spectrometry detergents for membrane proteomics
Anal. Bioanal. Chem., 2023, doi.org/10.1007/s00216-023-04584-z
Invited paper in the special issue: Young Investigators in (Bio-)Analytical Chemistry 2023

16.    L.H. Urner*, A. Ariamajd, A. Weikum
Combinatorial synthesis enables scalable designer detergents for membrane protein studies
Chem. Sci., 2022, doi.org/10.1039/D2SC03130B
Selected for the 2022 Chemical Science HOT Article Collection

15.   L.H. Urner*
Tailoring Purification and Analysis of Membrane Proteins with Modular Detergents
Methods in Molecular Biology, 2022, In: Mus-Veteau, I. (eds) Heterologous Expression of Membrane Proteins. Methods in Molecular Biology, vol 2507. Humana, New York, NY. doi.org/10.1007/978-1-0716-2368-8_19

14.   L.H. Urner*
Advances in membrane mimetics and mass spectrometry for understanding membrane structure and function
Curr. Opin. Chem. Biol., 2022, 69, 102157

13.   L.H.Urner*, I. Liko, K. Pagel, R. Haag, C.V. Robinson
Non-ionic hybrid detergents for protein delipidation
BBA Biomembranes, 2022, 183958
Invited paper in the special issue: Protons at bio-interfaces

12.   L.H. Urner*, E. Mohammadifar, K. Ludwig, D. Shutin, F. Fiorentino, I. Liko, F.G. Almeida, D. Kutifa, R. Haag, C.V. Robinson*
Anionic dendritic polyglycerol for protein purification and delipidation
ACS Appl. Polym. Mater. 2021, 3, 5903-5911

11. M. Agasid, L. Sørensen, L.H. Urner, J. Yun, C.V. Robinson*
The effect of sodium ions on ligand binding and conformational states of GPCRs – insights from mass spectrometry
 J. Am. Chem. Soc., 2021, 143, 4085-4089

10. L.H. Urner*, K. Goltsche, M, Seelent, M.-P. Schweder, I. Liko, C.V. Robinson, K. Pagel, R. Haag
Dendritic oligoglycerol regioisomer mixtures and their utility for membrane protein research
Chem. Eur. J., 2021, 27, 2537-2542

9. L.H. Urner*, M. Schulze, Y.B. Maier, W. Hoffmann, S. Warnke, I. Liko, K. Folmert, C. Manz, C.V. Robinson, R. Haag, K. Pagel*
A new azobenzene-based design strategy for detergents in membrane protein research
Chem. Sci., 2020, 11, 3538-3546

8. L.H. Urner, I. Liko, H.-Y. Yen, K.-K. Hoi, J.R. Bolla, J. Gault, F.G. Almeida, M.-P. Schweder, D. Shutin, S. Ehrmann, R. Haag*, C.V. Robinson*, K. Pagel*
Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors
Nat. Commun., 2020, 11, 564

7. L.H. Urner*, B. Schade, M. Schulze, K. Folmert, R. Haag, K. Pagel
Switchable solubility of azobenzene‐based bolaamphiphiles
ChemPhysChem, 2019, 20, 1690-1697

6. L.H. Urner, Y.B. Maier, R. Haag, K. Pagel*
Exploring the potential of dendritic oligoglycerol detergents for protein mass spectrometry
 J. Am. Soc. Mass Spectrom., 2019, 30, 174-180