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* corresponding author


16.    L.H. Urner*, A. Ariamajd, A. Weikum
Combinatorial synthesis enables scalable designer detergents for membrane protein studies
Chem. Sci., 2022,
Related press release from TU Dortmund University

15.   L.H. Urner*
Tailoring Purification and Analysis of Membrane Proteins with Modular Detergents
Methods in Molecular Biology, 2022, In: Mus-Veteau, I. (eds) Heterologous Expression of Membrane Proteins. Methods in Molecular Biology, vol 2507. Humana, New York, NY.

14.   L.H. Urner*
Advances in membrane mimetics and mass spectrometry for understanding membrane structure and function
Curr. Opin. Chem. Biol., 2022, 69, 102157

13.   L.H.Urner*, I. Liko, K. Pagel, R. Haag, C.V. Robinson
Non-ionic hybrid detergents for protein delipidation
BBA Biomembranes, 2022, 183958

2019 - 2021

12.   L.H. Urner*, E. Mohammadifar, K. Ludwig, D. Shutin, F. Fiorentino, I. Liko, F.G. Almeida, D. Kutifa, R. Haag, C.V. Robinson*
Anionic dendritic polyglycerol for protein purification and delipidation
ACS Appl. Polym. Mater. 2021, 3, 5903-5911

11. M. Agasid, L. Sørensen, L.H. Urner, J. Yun, C.V. Robinson*
The effect of sodium ions on ligand binding and conformational states of GPCRs – insights from mass spectrometry
 J. Am. Chem. Soc., 2021, 143, 4085-4089

10. L.H. Urner*, K. Goltsche, M, Seelent, M.-P. Schweder, I. Liko, C.V. Robinson, K. Pagel, R. Haag
Dendritic oligoglycerol regioisomer mixtures and their utility for membrane protein research
Chem. Eur. J., 2021, 27, 2537-2542

9. L.H. Urner*, M. Schulze, Y.B. Maier, W. Hoffmann, S. Warnke, I. Liko, K. Folmert, C. Manz, C.V. Robinson, R. Haag, K. Pagel*
A new azobenzene-based design strategy for detergents in membrane protein research
Chem. Sci., 2020, 11, 3538-3546

8. L.H. Urner, I. Liko, H.-Y. Yen, K.-K. Hoi, J.R. Bolla, J. Gault, F.G. Almeida, M.-P. Schweder, D. Shutin, S. Ehrmann, R. Haag*, C.V. Robinson*, K. Pagel*
Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors
Nat. Commun., 2020, 11, 564

7. L.H. Urner*, B. Schade, M. Schulze, K. Folmert, R. Haag, K. Pagel
Switchable solubility of azobenzene‐based bolaamphiphiles
ChemPhysChem, 2019, 20, 1690-1697

6. L.H. Urner, Y.B. Maier, R. Haag, K. Pagel*
Exploring the potential of dendritic oligoglycerol detergents for protein mass spectrometry
 J. Am. Soc. Mass Spectrom., 2019, 30, 174-180

2014 - 2018

5. H.V. Schröder, A. Mekic, H. Hupatz, S. Sobottka, F. Witte, L.H. Urner, M. Gaedke, K. Pagel, B. Sarkar, B. Paulus, C.A. Schalley*
Switchable synchronisation of pirouetting motions in a redox-active [3]rotaxane
Nanoscale, 2018, 10, 21425-21433

4. K. Huth, T. Heek, K. Achazi, C. Kuehne, L.H. Urner, K. Pagel, J. Dernedde, R. Haag*
Noncharged and charged monodendronised perylene bisimides as highly fluorescent labels and their bioconjugates
Chem. Eur. J., 2017, 23, 4849-4862

3. B.N.S. Thota*, L.H. Urner, R. Haag
Supramolecular architectures of dendritic amphiphiles in water
Chem. Rev., 2016, 116, 2079-2102

2. L.H. Urner, B.N.S. Thota, O. Nachtigall, S. Warnke, G. von Helden, R. Haag, K. Pagel*
Online monitoring the isomerization of an azobenzene-based dendritic bolaamphiphile using ion mobility-mass spectrometry
Chem. Commun., 2015, 51, 8801-8804

1. O. Nachtigall, C. Kördel, L.H. Urner, R. Haag*
Photoresponsive switches at surfaces based on supramolecular functionalization with azobenzene-oligoglycerol conjugates
Angew. Chem. Int. Ed., 2014, 53, 9669-9673

Patent Applications

L.H. Urner, F. Fiorentino, M. Agasid, D. Shutin, K. Pagel, R. Haag, C.V. Robinson
Hybrid detergents for the analysis of membrane proteins
UK patent application no. 2106700.4, filed: 11.05.2021

L.H. Urner, K. Pagel, S. Ehrmann, C.V. Robinson, I. Liko, H.-Y. Yen
Dendritic detergents for the analysis of proteins by mass spectrometry
UK patent application no. 1814356.0, WO2020/049294, filed: 04.09.2018

Highlighted References

New detergents for drug research
TU Dortmund University, published: 2022

The State of NRW Funding a New Junior Research Group at TU Dortmund University
TU Dortmund University, published: 2022

Modulare Detergenzien für GPCRs & Co
Wiley Analytical Science, published: 2021

Waschen und Wiegen für neue Wirkstoffe, Die forschenden Pharma-Unternehmen, published: 2020

Tipp 227: Neue Putzmittel für Membranproteine, Laborjournal
Laborjournal, published: 2020

Tree-like Detergent Molecules for Membrane Proteins
Freie Universität Berlin, published: 2020

“Trans Pro Idee”-Kurs ausgezeichnet: Forschungsideen erfolgreich umsetzen
Tagesspiegel, published: 2015

Location & approach

The campus of TU Dort­mund University is located close to interstate junction Dort­mund West, where the Sauerlandlinie A 45 (Frankfurt-Dort­mund) crosses the Ruhrschnellweg B 1 / A 40. The best interstate exit to take from A 45 is "Dort­mund-Eichlinghofen" (closer to Campus Süd), and from B 1 / A 40 "Dort­mund-Dorstfeld" (closer to Campus Nord). Signs for the uni­ver­si­ty are located at both exits. Also, there is a new exit before you pass over the B 1-bridge leading into Dort­mund.

To get from Campus Nord to Campus Süd by car, there is the connection via Vogelpothsweg/Baroper Straße. We recommend you leave your car on one of the parking lots at Campus Nord and use the H-Bahn (suspended monorail system), which conveniently connects the two campuses.

TU Dort­mund University has its own train station ("Dort­mund Uni­ver­si­tät"). From there, suburban trains (S-Bahn) leave for Dort­mund main station ("Dort­mund Hauptbahnhof") and Düsseldorf main station via the "Düsseldorf Airport Train Station" (take S-Bahn number 1, which leaves every 20 or 30 minutes). The uni­ver­si­ty is easily reached from Bochum, Essen, Mülheim an der Ruhr and Duisburg.

You can also take the bus or subway train from Dort­mund city to the uni­ver­si­ty: From Dort­mund main station, you can take any train bound for the Station "Stadtgarten", usually lines U41, U45, U 47 and U49. At "Stadtgarten" you switch trains and get on line U42 towards "Hombruch". Look out for the Station "An der Palmweide". From the bus stop just across the road, busses bound for TU Dort­mund University leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dort­mund main station to the stop "Dort­mund Kampstraße". From there, take U43 or U44 to the stop "Dort­mund Wittener Straße". Switch to bus line 447 and get off at "Dort­mund Uni­ver­si­tät S".

The H-Bahn is one of the hallmarks of TU Dort­mund University. There are two stations on Campus Nord. One ("Dort­mund Uni­ver­si­tät S") is directly located at the suburban train stop, which connects the uni­ver­si­ty directly with the city of Dort­mund and the rest of the Ruhr Area. Also from this station, there are connections to the "Technologiepark" and (via Campus Süd) Eichlinghofen. The other station is located at the dining hall at Campus Nord and offers a direct connection to Campus Süd every five minutes.

The AirportExpress is a fast and convenient means of transport from Dortmund Airport (DTM) to Dortmund Central Station, taking you there in little more than 20 minutes. From Dortmund Central Station, you can continue to the university campus by interurban railway (S-Bahn). A larger range of international flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the university station.

The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent "Technologiepark".

Site Map of TU Dortmund University (Second Page in English).