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Chemical Biology

Portrait Herbert Waldmann
Prof. (i.R.) Dr. Herbert Waldmann
Director Chemical Biology
“Max Planck Institut Of Molecular Physiology - MPI Dortmund”
Portrait Daniel Rauh
Prof. Dr. Daniel Rauh
“The Rauh group focuses on chemical biology, protein X-ray crystallography and medicinal chemistry research. We employ organic synthesis, structural biology, structure-based ligand design, biochemical and cellular compound screening, as well as target identification for the development of inhibitors and functional probes to target proteins with relevance to cancer.”
Portrait Philippe Bastiaens
Prof. Dr. Philippe Bastiaens
Director Systemic Cell Biology
“Max Planck Institut Of Molecular Physiology - MPI Dortmund”
Portrait Daniel Summerer
Prof Dr. Daniel Summerer
“We devise chemical-biological concepts to study regulatory processes in cellular chromatin. By combining principles of directed molecular evolution and optochemical biology with imaging and high throughput sequencing, we currently focus on dissecting the roles of epigenetic DNA modifications in the regulation of Protein-DNA complex formation on the local and global level.”
Portrait Hannes Mutschler
Prof. Dr. Hannes Mutschler
Portrait Stefan Raunser
apl. Prof. Dr. Stefan Raunser
Structural Biochemistry
“Max Planck Institute of Molecular Physiology - MPI-Dortmund”
Portrait Susanne Brakmann
apl. Prof. Dr. Susanne Brakmann
“Our research interests lie at the interface of chemical biology and synthetic biology with an emphasis on molecular methods to study, manipulate and apply enzymatic catalysis. For this, our work is based on a method repertoire ranging from synthetic chemistry (e.g., for the synthesis of probes and substrates) and molecular biology (for the generation, modification and preparation of recombinant proteins) to biophysical chemistry (for the analysis and characterization of enzyme structure and activity).”
Portrait Michael Edmund Beck
Prof. hc. Dr. Michael Edmund Beck
“I‘m passionate about any aspect of mathematical methods applied to not just accelerate our hunt for new cures of human or plant disease, but more importantly deepen our understanding of the molecular mechanisms behind different principles of biological activity. Being rooted in physics-based approaches, like quantum chemistry and molecular dynamics, I also strongly believe in the interplay of mechanistic models and artificial intelligence and pursue research at this boundary, too.”
Portrait Leif Dehmelt
PD Dr. Dehmelt
“The development and function of multicellular organisms critically depends on regulated cell morphology changes. Perturbations in the signal networks that control these changes can lead to developmental anomalies or cancer. In our research group, we investigate how the morphology and function of mammalian cells is controlled by such signal networks. We particularly focus on self-organizing pattern forming mechanisms that emerge from coupled reactions and diffusion of molecules inside individual cells [1-3]. To study these systems, we implement an interdisciplinary approach [4,5] that combines acute, microscopy-based experimental perturbations, the development of novel analysis technologies and mathematical modeling.”
Portrait Malte Gersch
Dr. Malte Gersch
“Our lab aims to understand molecular mechanisms by which proteolytic enzymes control post-translational modifications in the Ubiquitin system with a view to exploit these insights towards novel therapeutic approaches. We work as a multidisciplinary team, integrating chemical biology, organic chemistry, biochemistry, structural biology and cellular assays.”
Portrait Leonhard Urner
Dr. Leonhard Urner
“Our aims are to find new compounds against resistant bacteria and to understand how biomembranes influence the effect of drugs. Our group combines the fields of organic chemistry, supramolecular chemistry, and molecular biology.”
Portrait Sidney Becker
Dr. Sidney Becker
“Molecular evolution is not only responsible for the emergence of life but also for the development of higher organisms. Evolution is a powerful tool that continuously provides innovative solutions to adapt to environmental changes. However, it is also responsible for many problems. The rise of antibiotic resistance and diseases such as cancer are the direct consequence of molecular evolution. The Becker group aims to better understand and utilise the fundamental principles of evolution to provide innovative molecular tools for both diagnostic and therapeutic applications.”