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Chemical Biology

Portrait Herbert Waldmann
Prof. Dr. Herbert Waldmann
Director Chemical Biology
“Max Planck Institut Of Molecular Physiology - MPI Dort­mund
Portrait Daniel Rauh
Prof. Dr. Daniel Rauh
“The Rauh group focuses on chemical biology, protein X-ray crystallography and medicinal chem­is­try re­search. We employ organic synthesis, structural biology, structure-based ligand de­sign, biochemical and cellular compound screening, as well as target identification for the development of inhibitors and functional probes to target proteins with relevance to cancer.”
Portrait Philippe Bastiaens
Prof. Dr. Philippe Bastiaens
Director Systemic Cell Biology
“Max Planck Institut Of Molecular Physiology - MPI Dort­mund
Portrait Daniel Summerer
Prof Dr. Daniel Summerer
“We devise chemical-biological concepts to study regulatory processes in cellular chromatin. By combining principles of directed molecular evolution and optochemical biology with imaging and high throughput sequencing, we currently focus on dissecting the roles of epigenetic DNA mod­i­fi­ca­tions in the regulation of Protein-DNA complex formation on the local and global level.”
Portrait Paul Czodrowski
Prof. Dr. Paul Czodrowski
“The Czodrowski Lab com­bines molecular biology, medicinal chem­is­try and artificial intelligence to answer fundamental chemical biology questions such as molecular recognition and protein structure/dynamics with the aim to faster and more effectively cure diseases such as cancer.”
Prof. Dr. Hannes Mutschler
“Workgroup”
Portrait Stefan Raunser
apl. Prof. Dr. Stefan Raunser
Structural Biochemistry
“Max Planck In­sti­tute of Molecular Physiology - MPI-Dort­mund
Portrait Susanne Brakmann
apl. Prof. Dr. Susanne Brakmann
“Our re­search interests lie at the interface of chemical biology and synthetic biology with an emphasis on molecular methods to study, manipulate and apply enzymatic catalysis. For this, our work is based on a method repertoire ranging from synthetic chem­is­try (e.g., for the synthesis of probes and substrates) and molecular biology (for the gen­era­tion, modification and preparation of recombinant proteins) to biophysical chem­is­try (for the analysis and characterization of enzyme structure and activity).”
Portrait Andreas Brunschweiger
Dr. An­dre­as Brunschweiger
“We use molecular evolution technology for identification of bioactive compounds: DNA-encoded libraries (DELs). We develop DNA-barcoding strategies, and synthesis methodology, use cheminformatics-assisted library de­sign, and perform screening on disease-relevant targets. DEL screens uncovered inhibitors of a cancer mechanism.”
Portrait Leif Dehmelt
PD Dr. Dehmelt
“The development and function of multicellular organisms critically depends on regulated cell morphology changes. Perturbations in the signal networks that control these changes can lead to developmental anomalies or cancer. In our re­search group, we investigate how the morphology and function of mammalian cells is con­trolled by such signal networks. We particularly focus on self-organizing pattern forming mecha­nisms that emerge from coupled reactions and diffusion of mol­ecules inside individual cells [1-3]. To study these systems, we implement an inter­dis­ci­plin­ary approach [4,5] that com­bines acute, mi­cros­co­py-based experimental perturbations, the development of novel analysis technologies and mathematical modeling.”
Portrait Malte Gersch
Dr. Malte Gersch
“Our lab aims to understand molecular mecha­nisms by which proteolytic enzymes control post-translational mod­i­fi­ca­tions in the Ubiquitin system with a view to exploit these insights towards novel therapeutic approaches. We work as a multidisciplinary team, integrating chemical biology, organic chem­is­try, biochemistry, structural biology and cellular assays.”

Location & approach

The campus of TU Dort­mund Uni­ver­sity is located close to interstate junction Dort­mund West, where the Sauerlandlinie A 45 (Frankfurt-Dort­mund) crosses the Ruhrschnellweg B 1 / A 40. The best interstate exit to take from A 45 is "Dort­mund-Eichlinghofen" (closer to Cam­pus Süd), and from B 1 / A 40 "Dort­mund-Dorstfeld" (closer to Cam­pus Nord). Signs for the uni­ver­si­ty are located at both exits. Also, there is a new exit before you pass over the B 1-bridge leading into Dort­mund.

To get from Cam­pus Nord to Cam­pus Süd by car, there is the connection via Vo­gel­pothsweg/Baroper Straße. We recommend you leave your car on one of the parking lots at Cam­pus Nord and use the H-Bahn (suspended monorail system), which conveniently connects the two campuses.

TU Dort­mund Uni­ver­sity has its own train station ("Dort­mund Uni­ver­si­tät"). From there, suburban trains (S-Bahn) leave for Dort­mund main station ("Dort­mund Hauptbahnhof") and Düsseldorf main station via the "Düsseldorf Airport Train Station" (take S-Bahn number 1, which leaves every 20 or 30 minutes). The uni­ver­si­ty is easily reached from Bochum, Essen, Mülheim an der Ruhr and Duis­burg.

You can also take the bus or subway train from Dort­mund city to the uni­ver­si­ty: From Dort­mund main station, you can take any train bound for the Station "Stadtgarten", usually lines U41, U45, U 47 and U49. At "Stadtgarten" you switch trains and get on line U42 towards "Hombruch". Look out for the Station "An der Palmweide". From the bus stop just across the road, busses bound for TU Dort­mund Uni­ver­sity leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dort­mund main station to the stop "Dort­mund Kampstraße". From there, take U43 or U44 to the stop "Dort­mund Wittener Straße". Switch to bus line 447 and get off at "Dort­mund Uni­ver­si­tät S".

The H-Bahn is one of the hallmarks of TU Dort­mund Uni­ver­sity. There are two stations on Cam­pus Nord. One ("Dort­mund Uni­ver­si­tät S") is directly located at the suburban train stop, which connects the uni­ver­si­ty directly with the city of Dort­mund and the rest of the Ruhr Area. Also from this station, there are connections to the "Technologiepark" and (via Cam­pus Süd) Eichlinghofen. The other station is located at the dining hall at Cam­pus Nord and offers a direct connection to Cam­pus Süd every five minutes.

The AirportExpress is a fast and convenient means of transport from Dort­mund Airport (DTM) to Dort­mund Central Station, taking you there in little more than 20 minutes. From Dort­mund Central Station, you can continue to the uni­ver­si­ty campus by interurban railway (S-Bahn). A larger range of in­ter­na­tio­nal flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the uni­ver­si­ty station.

The facilities of TU Dort­mund Uni­ver­sity are spread over two campuses, the larger Cam­pus North and the smaller Cam­pus South. Additionally, some areas of the uni­ver­si­ty are located in the adjacent "Technologiepark".

Site Map of TU Dort­mund Uni­ver­sity (Second Page in English).