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Chemical Biology

Portrait Herbert Waldmann
Prof. Dr. Herbert Waldmann
Director Chemical Biology
“Max Planck Institut Of Molecular Physiology - MPI Dortmund”
Portrait Daniel Rauh
Prof. Dr. Daniel Rauh
“The Rauh group focuses on chemical biology, protein X-ray crystallography and medicinal chemistry research. We employ organic synthesis, structural biology, structure-based ligand design, biochemical and cellular compound screening, as well as target identification for the development of inhibitors and functional probes to target proteins with relevance to cancer.”
Portrait Philippe Bastiaens
Prof. Dr. Philippe Bastiaens
Director Systemic Cell Biology
“Max Planck Institut Of Molecular Physiology - MPI Dortmund”
Portrait Daniel Summerer
Prof Dr. Daniel Summerer
“We devise chemical-biological concepts to study regulatory processes in cellular chromatin. By combining principles of directed molecular evolution and optochemical biology with imaging and high throughput sequencing, we currently focus on dissecting the roles of epigenetic DNA modifications in the regulation of Protein-DNA complex formation on the local and global level.”
Portrait Hannes Mutschler
Prof. Dr. Hannes Mutschler
Portrait Stefan Raunser
apl. Prof. Dr. Stefan Raunser
Structural Biochemistry
“Max Planck Institute of Molecular Physiology - MPI-Dortmund”
Portrait Susanne Brakmann
apl. Prof. Dr. Susanne Brakmann
“Our research interests lie at the interface of chemical biology and synthetic biology with an emphasis on molecular methods to study, manipulate and apply enzymatic catalysis. For this, our work is based on a method repertoire ranging from synthetic chemistry (e.g., for the synthesis of probes and substrates) and molecular biology (for the generation, modification and preparation of recombinant proteins) to biophysical chemistry (for the analysis and characterization of enzyme structure and activity).”
Portrait Andreas Brunschweiger
Dr. Andreas Brunschweiger
“We use molecular evolution technology for identification of bioactive compounds: DNA-encoded libraries (DELs). We develop DNA-barcoding strategies, and synthesis methodology, use cheminformatics-assisted library design, and perform screening on disease-relevant targets. DEL screens uncovered inhibitors of a cancer mechanism.”
Portrait Leif Dehmelt
PD Dr. Dehmelt
“The development and function of multicellular organisms critically depends on regulated cell morphology changes. Perturbations in the signal networks that control these changes can lead to developmental anomalies or cancer. In our research group, we investigate how the morphology and function of mammalian cells is controlled by such signal networks. We particularly focus on self-organizing pattern forming mechanisms that emerge from coupled reactions and diffusion of molecules inside individual cells [1-3]. To study these systems, we implement an interdisciplinary approach [4,5] that combines acute, microscopy-based experimental perturbations, the development of novel analysis technologies and mathematical modeling.”
Portrait Malte Gersch
Dr. Malte Gersch
“Our lab aims to understand molecular mechanisms by which proteolytic enzymes control post-translational modifications in the Ubiquitin system with a view to exploit these insights towards novel therapeutic approaches. We work as a multidisciplinary team, integrating chemical biology, organic chemistry, biochemistry, structural biology and cellular assays.”
Portrait Leonhard Urner
Dr. Leonhard Urner
“Our aims are to find new compounds against resistant bacteria and to understand how biomembranes influence the effect of drugs. Our group combines the fields of organic chemistry, supramolecular chemistry, and molecular biology.”
Portrait Sidney Becker
Dr. Sidney Becker
“Molecular evolution is not only responsible for the emergence of life but also for the development of higher organisms. Evolution is a powerful tool that continuously provides innovative solutions to adapt to environmental changes. However, it is also responsible for many problems. The rise of antibiotic resistance and diseases such as cancer are the direct consequence of molecular evolution. The Becker group aims to better understand and utilise the fundamental principles of evolution to provide innovative molecular tools for both diagnostic and therapeutic applications.”

Location & approach

The campus of TU Dort­mund University is located close to interstate junction Dort­mund West, where the Sauerlandlinie A 45 (Frankfurt-Dort­mund) crosses the Ruhrschnellweg B 1 / A 40. The best interstate exit to take from A 45 is "Dort­mund-Eichlinghofen" (closer to Campus Süd), and from B 1 / A 40 "Dort­mund-Dorstfeld" (closer to Campus Nord). Signs for the uni­ver­si­ty are located at both exits. Also, there is a new exit before you pass over the B 1-bridge leading into Dort­mund.

To get from Campus Nord to Campus Süd by car, there is the connection via Vogelpothsweg/Baroper Straße. We recommend you leave your car on one of the parking lots at Campus Nord and use the H-Bahn (suspended monorail system), which conveniently connects the two campuses.

TU Dort­mund University has its own train station ("Dort­mund Uni­ver­si­tät"). From there, suburban trains (S-Bahn) leave for Dort­mund main station ("Dort­mund Hauptbahnhof") and Düsseldorf main station via the "Düsseldorf Airport Train Station" (take S-Bahn number 1, which leaves every 20 or 30 minutes). The uni­ver­si­ty is easily reached from Bochum, Essen, Mülheim an der Ruhr and Duisburg.

You can also take the bus or subway train from Dort­mund city to the uni­ver­si­ty: From Dort­mund main station, you can take any train bound for the Station "Stadtgarten", usually lines U41, U45, U 47 and U49. At "Stadtgarten" you switch trains and get on line U42 towards "Hombruch". Look out for the Station "An der Palmweide". From the bus stop just across the road, busses bound for TU Dort­mund University leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dort­mund main station to the stop "Dort­mund Kampstraße". From there, take U43 or U44 to the stop "Dort­mund Wittener Straße". Switch to bus line 447 and get off at "Dort­mund Uni­ver­si­tät S".

The H-Bahn is one of the hallmarks of TU Dort­mund University. There are two stations on Campus Nord. One ("Dort­mund Uni­ver­si­tät S") is directly located at the suburban train stop, which connects the uni­ver­si­ty directly with the city of Dort­mund and the rest of the Ruhr Area. Also from this station, there are connections to the "Technologiepark" and (via Campus Süd) Eichlinghofen. The other station is located at the dining hall at Campus Nord and offers a direct connection to Campus Süd every five minutes.

The AirportExpress is a fast and convenient means of transport from Dortmund Airport (DTM) to Dortmund Central Station, taking you there in little more than 20 minutes. From Dortmund Central Station, you can continue to the university campus by interurban railway (S-Bahn). A larger range of international flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the university station.

The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent "Technologiepark".

Site Map of TU Dortmund University (Second Page in English).