Kamps D, Koch J, Juma VO, Campillo-Funollet E, Graessl M, Banerjee S, Mazel T, Chen X, Wu YW, Portet S, Madzvamuse A, Nalbant P, Dehmelt L, (2020).
Optogenetic Tuning Reveals Rho Amplification-Dependent Dynamics of a Cell Contraction Signal Network.
Cell Reports 33(9):108467
Chen X, Venkatachalapathy M, Dehmelt L, Wu Y-W:
Multi-directional activity control (MAC) of cellular processes enabled by a versatile chemo-optogenetic approach.
Angew Chem Int Ed, 57:11993 (2018) (impact factor 11.26)
Nalbant P, Dehmelt L:
Exploratory cell shape changes: a sense of touch for cells?
Biol Chem (2018) 399:809 (corresponding author) (impact factor 3.27)
Graessl M, Koch J, Calderon A, Kamps D, Banerjee S, Mazel T, Schulze N, Jungkurth JK, Patwardhan R, Solouk D, Hampe N, Hoffmann B, Dehmelt L, Nalbant P:
An excitable Rho GTPase signaling network generates dynamic subcellular contraction patterns,
J Cell Biol. 216:4271 (2017) (featured in Spotlight article J Cell Biol. 216: 3899; corresponding author) (impact factor 7.96)
Kamps D, Dehmelt L.
Deblurring Signal Network Dynamics.
ACS Chem Biol. 12:2231 (2017) (corresponding author) (impact factor 5.00)
Chen X, Venkatachalapathy M, Kamps D, Weigel S, Kumar R, Orlich M, Garrecht R, Hirtz M, Niemeyer CM, Wu Y-W, Dehmelt L,
Molecular Activity Painting”: Switch-like, Light-Controlled Perturbations inside Living Cells,
Angew Chem Int Ed 56:5916 (2017) (corresponding author) (impact factor 11.26)
Arndt HD, Rizzo S, Nöcker C, Wakchaure VN, Milroy LG, Bieker V, Calderon A, Tran TT, Brand S, Dehmelt L, Waldmann H:
Divergent solid-phase synthesis of natural product-inspired bipartite cyclodepsipeptides: total synthesis of seragamide A.
Chemistry 21:5311 (2015) (impact factor 5.73)
Liu P, Calderon A, Konstantinidis G, Hou J, Voss S, Chen X, Li F, Banerjee S, Hoffmann J-E, Theiss C, Dehmelt L, Wu Y-W:
A Bioorthogonal Small-molecule Switch System for Controlling Protein Function in Cells.
Angew Chem Int Ed 53:10049 (2014) (impact factor 11.26)
Cytoskeletal self-organization in neuromorphogenesis.
Bioarchitecture 4:75 (2014) (corresponding author) (impact factor N/A)
Arrabito G, Schroeder H, Schröder K, Filips C, Marggraf U, Dopp C, Venkatachalapathy M, Dehmelt L, Bastiaens PIE, Neyer A, and Niemeyer CM:
Configurable Low-cost Plotter Device for Fabrication of Multi-Color Sub-Cellular Scale Microarrays.
Small 10:2870 (2014) (impact factor 8.37)
Schulze N, Gräßl M, Soares AB, Geyer M, Dehmelt L, Nalbant P:
FHOD1 regulates stress fiber organization by controlling transversal arc and dorsal fiber dynamics.
J Cell Sci 127:1379 (2014) (impact factor 5.43)
Mazel T, Biesemann A, Krejczy M, Nowald J, Müller O and Dehmelt L:
Direct observation of microtubule pushing by cortical dynein in living cells.
Mol Biol Cell 25:95 (2014) (corresponding author) (impact factor 4.47)
Arens J, Duong T-T and Dehmelt L:
A Morphometric Screen Identifies Specific Roles for Microtubule-Regulating Genes in Neuronal Development of P19 Stem Cells.
PLoS One 8:e79796 (2013) (corresponding author) (impact factor 3.23)
Arrabito G, Reisewitz S, Dehmelt L, Bastiaens PI, Pignataro B, Schroeder H, and Niemeyer CM:
Biochips for Cell Biology by Combined Dip-Pen Nanolithography and DNA-Directed Protein Immobilization.
Small 9:4243 (2013) (impact factor 8.37)
Schönichen A, Mannherz HG, Behrmann E, Mazur AJ, Kühn S, Fackler OT, Raunser S, Dehmelt L and Geyer M:
FHOD1 is an actin bundling factor that dynamically and selectively associates with stress fibers and actin arcs.
J Cell Sci 126:1891 (2013) (impact factor 5.43)
Gandor S, Reisewitz S, Venkatachalapathy M, Arrabito G, Reibner M, Schröder H, Ruf K, Niemeyer CM, Bastiaens PIH, Dehmelt L:
A Protein Interaction Array Inside a Living Cell.
Angew Chem Int Ed 52:4790 (2013) (featured in Faculty of 1000 and Biotechniques 2013 55:11; corresponding author) (impact factor 11.26)
Blümer J, Rey J, Dehmelt L, Mazel T, Bastiaens P, Goody RS, Itzen A:
RabGEFs are sufficient for specific Rab membrane targeting.
J Cell Biol 200:287 (2013) (featured in Faculty of 1000) (impact factor 9.83)
Tennstaedt A, Pöpsel S, Truebestein L, Hauske P, Brockmann A, Schmidt N, Irle I, Sacca B, Niemeyer CM, Brandt R, Ksiezak-Reding H, Tirniceriu AL, Egensperger R, Baldi A, Dehmelt L, Kaiser M, Huber R, Clausen T, Ehrmann M:
Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.
J Biol Chem 287:20931 (2012) (impact factor 4.57)
Milroy LG, Rizzo S, Calderon A, Ellinger B, Erdmann S, Mondry J, Verveer P, Bastiaens P, Waldmann H, Dehmelt L, Arndt HD:
Selective chemical imaging of static actin in live cells.
J Am Chem Soc 134:8480 (2012) (corresponding author) (impact factor 12.11)
Dehmelt L, Poplawski G, Hwang E, Halpain S: NeuriteQuant:
An open source toolkit for high content screens of neuronal morphogenesis.
BMC Neurosci 12:100 (2011) (corresponding author) (impact factor 2.67)
The dynamics of the cellular skeleton. How molecular "speckles" can reveal cellular building blocks.
Systembiologie.De (Int. Ed.) 3:59 (2011) (corresponding author) (impact factor N/A)
Dehmelt L and Bastiaens P
Self-Organization in Cells.
In Principles of Evolution (eds. H. Meyer-Ortmanns and S. Thurner), pp. 219-238. Heidelberg: Springer. (2011) (impact factor N/A)
Fath T, Fischer RS, Dehmelt L, Halpain S, Fowler VM:
Tropomodulins are negative regulators of neurite outgrowth.
Eur J Cell Biol 90:291 (2011) (impact factor 3.83)
Dehmelt L and Bastiaens PI:
Spatial organization of intracellular communication: insights from imaging.
Nat Rev Mol Cell Biol 11:440 (2010) (impact factor 37.81)
Weinrich D, Köhn M, Jonkheijm P, Westerlind U, Dehmelt L, Engelkamp H, Christianen PC, Kuhlmann J, Maan JC, Nüsse D, Schröder H, Wacker R, Voges E, Breinbauer R, Kunz H, Niemeyer CM, Waldmann H.
Preparation of biomolecule microstructures and microarrays by thiol-ene photoimmobilization.
Chembiochem 11:235 (2010) (impact factor 3.09)
Halpain S, Calabrese B, and Dehmelt L:
Actin Cytoskeleton in Growth Cones, Nerve Terminals, and Dendritic Spines.
Encyclopedia for Neuroscience, (Ed. Larry Squire), pp. 15-21. (2008) (impact factor N/A)
Dehmelt L, Halpain S.:
Neurite Outgrowth: A Flick of the Wrist.
Curr Biol 17:R611 (2007) (impact factor 9.57)
Dehmelt L, Nalbant P, Steffen W, Halpain S.:
A Microtubule-Based, Dynein-Dependent Force Induces Local Cell Protrusions: Implications for Neurite Initiation.
Brain Cell Biology 35:39 (2006) (impact factor 3.25)
Halpain S, Dehmelt L:
The MAP1 family of microtubule-associated proteins.
Genome Biology 7:224 (2006) (corresponding author) (impact factor 10.81)
Dehmelt L, Halpain S:
MAP2/tau family proteins.
Genome Biology 6:204 (2005) (impact factor 10.81)
Roger B, Al-Bassam J, Dehmelt L, Milligan RA, Halpain S:
MAP2c, but not tau, binds and bundles F-actin via its microtubule binding domain.
Curr Biol 14:363 (2004) (featured in N&V, Nature Cell Biology 6:390) (impact factor 9.57)
Dehmelt L, Halpain S:
Actin and microtubules in neurite initiation: Are MAPs the missing link?
J Neurobiol 58:18 (2004) (impact factor 3.84)
Dehmelt L, Smart FM, Ozer RS, Halpain S:
The role of microtubule-associated protein 2c in the reorganization of microtubules and lamellipodia during neurite initiation.
J Neurosci 23:9479 (2003) (impact factor 6.34)
Werner A, Preston-Fayers K, Dehmelt L, Nalbant P:
Regulation of the NPT gene by a naturally occurring antisense transcript.
Cell Biochem Biophys 36:241 (2002) (impact factor 1.68)
Lerche C, Seebohm G, Wagner CI, Scherer CR, Dehmelt L, Abitbol I, Gerlach U, Brendel J, Attali B, Busch AE:
Molecular impact of MinK on the enantiospecific block of IKs by chromanols.
Br J Pharmacol 131:1503 (2000) (impact factor 4.84)
Nalbant P, Boehmer C, Dehmelt L, Wehner F, Werner A:
Functional characterization of a Na+-phosphate cotransporter (NaPi-II) from zebrafish and identification of related transcripts.
J Physiol 520:79 (1999) (impact factor 5.04)
Werner A, Dehmelt L, Nalbant P:
Na+-dependent phosphate cotransporters: The NaPi protein families.
J Exp Biol 201:3135 (1998) (impact factor 2.90)
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Location & approach
The campus of TU Dortmund University is located close to interstate junction Dortmund West, where the Sauerlandlinie A 45 (Frankfurt-Dortmund) crosses the Ruhrschnellweg B 1 / A 40. The best interstate exit to take from A 45 is "Dortmund-Eichlinghofen" (closer to Campus Süd), and from B 1 / A 40 "Dortmund-Dorstfeld" (closer to Campus Nord). Signs for the university are located at both exits. Also, there is a new exit before you pass over the B 1-bridge leading into Dortmund.
To get from Campus Nord to Campus Süd by car, there is the connection via Vogelpothsweg/Baroper Straße. We recommend you leave your car on one of the parking lots at Campus Nord and use the H-Bahn (suspended monorail system), which conveniently connects the two campuses.
TU Dortmund University has its own train station ("Dortmund Universität"). From there, suburban trains (S-Bahn) leave for Dortmund main station ("Dortmund Hauptbahnhof") and Düsseldorf main station via the "Düsseldorf Airport Train Station" (take S-Bahn number 1, which leaves every 20 or 30 minutes). The university is easily reached from Bochum, Essen, Mülheim an der Ruhr and Duisburg.
You can also take the bus or subway train from Dortmund city to the university: From Dortmund main station, you can take any train bound for the Station "Stadtgarten", usually lines U41, U45, U 47 and U49. At "Stadtgarten" you switch trains and get on line U42 towards "Hombruch". Look out for the Station "An der Palmweide". From the bus stop just across the road, busses bound for TU Dortmund University leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dortmund main station to the stop "Dortmund Kampstraße". From there, take U43 or U44 to the stop "Dortmund Wittener Straße". Switch to bus line 447 and get off at "Dortmund Universität S".
The H-Bahn is one of the hallmarks of TU Dortmund University. There are two stations on Campus Nord. One ("Dortmund Universität S") is directly located at the suburban train stop, which connects the university directly with the city of Dortmund and the rest of the Ruhr Area. Also from this station, there are connections to the "Technologiepark" and (via Campus Süd) Eichlinghofen. The other station is located at the dining hall at Campus Nord and offers a direct connection to Campus Süd every five minutes.
The AirportExpress is a fast and convenient means of transport from Dortmund Airport (DTM) to Dortmund Central Station, taking you there in little more than 20 minutes. From Dortmund Central Station, you can continue to the university campus by interurban railway (S-Bahn). A larger range of international flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the university station.
The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent "Technologiepark".