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Publications- Selected Articles and Letters


Total Synthesis and Structural Assignment of (‒)-Fusaequisin A
A.-C. Schmidt, M. Hiersemann*
Chem. Eur. J. 2021, 28, e202103558


Photochemical Approach to the Cyclohepta[b]indole Scaffold by Annulative Two‐Carbon Ring‐Expansion
D. C. Tymann, L. Benedix, L. Iovkova, R. Pallach, S. Henke, D. Tymann, M. Hiersemann*
Chem. Eur. J. 2020, 26, 11974–11978


Synthesis of a Diastereomer of the Marine Macrolide Lytophilippine A
A. Klüppel, A. Gille, C. E. Karayel, M. Hiersemann*
Org. Lett. 2019, 21, 2421-2425


Development of an Alkyne Analogue of the de Mayo Reaction for the Synthesis od Medium-Sized Carbacycles and Cyclohepta[b]indoles
D. Tymann, D. C. Tymann, U. Bednarzick, L. Iovkova-Berends, J. Rehbein, M. Hiersemann*
Angew. Chem. 2018, 130, 47, 15779-15783

Progress Toward the Total Synthesis of Gukulenin A: Photochemically Triggered Two-Carbon Ring Expansion Key to α-Tropolonic Ether Synthesis
D. Tymann*, U. Bednarzick, L. Iovkova-Berends, M. Hiersemann
Org. Lett. 2018, 20, 4072-4076


Synthesis of Homoverrucosanoid-Derived Esters and Evaluation as MDR Modulators
A. Schäfer*, S. C. Köhler, M. Lohe, M. Wiese*, M. Hiersemann 
J. Org. Chem. 2017, 82, 10504-10522

Total Synthesis and Structural Assignment of Curvicollide C
V. von Kiedrowski*, F. Quentin, M. Hiersemann*
Org. Lett. 2017, 19, 4391-4394

Synthesis of the Cyclohepta[e]hydrindane Core of the Marine Homoverrucosane Diterpenoid Gagunin E
A. Schäfer*, M. Hiersemann
Org. Lett. 2017, 19, 814-817


Cyclopentanoids by Uncatalyzed Intramolecular Carbonyl Ene (ICE) Reaction of α-Keto Esters
D. Tymann*, A. Klüppel, W. Hiller, M. Hiersemann*
Org. Lett. 2014, 16, 4062-4065

Catalytic Asymmetric Claisen Rearrangement of Gosteli-Type Allyl Vinyl Ethers: Total Synthesis of (−)-9,10-Dihydro Ecklonialacetone B
J. Becker, L. Butt, V. von Kiedrowski, E. Mischler, F. Quentin, M. Hiersemann*
J. Org. Chem. 2014, 79, 3040-3051


Total Synthesis  of (−)-Ecklonialacetone B
J. Becker, L. Butt, V. von Kiedrowski, E. Mischler, F. Quentin, M. Hiersemann*
Org. Lett. 2013, 15, 5982-5985


{1,6}-Transannular Catalytic Asymmetric Gosteli-Claisen Rearrangement
T. Jaschinski, M. Hiersemann*
Org. Lett. 2012, 14, 4114–4117

Palladium(II)-Catalyzed Cyclosiomerization of Substituted 1,5-Hexadienes: A Combined Experimental and Computational Study on an Open and an Interrupted Hydropalladation/Carbopalladation/β-Hydride Elimination (HCHe) Catalytic Cycle
B. Nelson*, S. Herres-PawlisW. Hiller, H. Preut, C. Strohmann, M. Hiersemann*
J. Org. Chem. 2012, 77, 4980–4995


Palladium(II)-Catalyzed Cycloisomerization of Functionalized 1,5-Hexadienes
B. Nelson,  W. Hiller, A. Pollex, M. Hiersemann*
Org. Lett. 2011, 13, 16, 4438–4441

Integration of Catalysis and Analysis is the Key: Rapid and Precise Investigation of the Catalytic Asymmetric Gosteli-Claisen Rearrangement
J. Troendlin, J. Rehbein, M. Hiersemann, O. Trapp
J. Am. Chem. Soc. 2011, 133, 16444–16450

Gosteli-Claisen Rearrangement of Propargyl Vinyl Ethers: Cascading Molecular Rearrangements
A. Gille, J. Rehbein, M. Hiersemann*
Org. Lett. 2011, 13, 2122–2125

Total Synthesis of Natural and Non–Natural Jatrophane Diterpenes and their Evaluation as MDR Modulators
C. Schnabel, K. Sterz, H. Müller, J. Rehbein M. Wiese*, M. Hiersemann*
J. Org. Chem. 2011, 76, 512–522


(−)-Lytophilippine A: Synthesis of a C1-C18 Building Block
A. Gille*, M. Hiersemann*
Org. Lett. 2010, 12, 5258–5261


Total Synthesis of Jatrophane Diterpenes from Euphorbia characias
C. Schnabel, M. Hiersemann*
Org. Lett. 2009, 11, 2555–2558

Gosteli–Claisen Rearrangement: DFT Study of Substituent-Rate Effects
J. Rehbein, M. Hiersemann*
J. Org. Chem. 2009, 74, 4336–4342

Synthetic Studies toward Jatrophane Diterpenes from Euphorbia characias. Enantioselective Synthesis of(−)-15-O-Acetyl-3-O-propionyl-17-norcharaciol
H. Helmboldt, M. Hiersemann*
J. Org. Chem. 2009, 74, 1698–1708

Gosteli-Claisen Rearrangement: Substrate Synthesis, Simple Diastereoselectivity and Kinetic Studies
J. Rehbein*, S. Leick, M. Hiersemann*
J. Org. Chem. 2009, 74, 1531–1540


Enantioselective Total Synthesis of the C8-C20 Segment of Curvicollide C
M. Körner, M. Hiersemann*
Org. Lett. 2007, 9, 4979–4982

Organocatalytic Claisen Rearrangement: Theory and Experiment
M. Kirsten, J. Rehbein T. Strassner*, M. Hiersemann*
J. Org. Chem. 2007, 72, 4001–4011


Synthesis of the Norjatrophane Diterpene (−)-15-Acetyl-3-propionyl-17-norcharaciol
H. Helmboldt, D. Köhler, M. Hiersemann*
Org. Lett. 2006, 8, 1573–1576


Catalytic Asymmetric Claisen Rearrangement in Natural Product Synthesis: Synthetic Studies toward (–)-Xeniolide F
A. Pollex, M. Hiersemann*
Org. Lett. 2005, 7, 5705–5708

Ester Dienolate [2,3]-Wittig Rearrangement in Natural Product Synthesis: Diastereoselective Total Synthesis of the Triester of Viridiofungin A, A2, and A4
A. Pollex, A. Millet, J. Müller, M. Hiersemann*, L. Abraham
J. Org. Chem. 2005, 70, 5579–5591


The Catalytic Enantioselective Claisen Rearrangement of an Allyl Vinyl Ethers
L. Abraham, R. Czerwonka, M. Hiersemann*
Angew. Chem. Int. Ed. 2001, 40, 4700–4703

The Cu(OTf)2- and Yb(OTf)3-Catalyzed Claisen Rearrangement of 2-Alkoxycarbonyl-Substituted Allyl Vinyl Ethers
M. Hiersemann*, L. Abraham
Org. Lett. 2001, 3, 49–52


Chiral Acetals as Stereoinductors: Diastereoface Selective Alkylation of Dihydrobenzoxazine-Derived Amide Enolates
J. Mulzer*, O. Langer, M. Hiersemann*, J. W. Bats, J. Buschmann, P. Luger
J. Org. Chem. 2000, 65, 6540–6546