Publications- Selected Articles and Letters
2021
Total Synthesis and Structural Assignment of (‒)-Fusaequisin A
A.-C. Schmidt, M. Hiersemann*
Chem. Eur. J. 2021, 28, e202103558
2020
Photochemical Approach to the Cyclohepta[b]indole Scaffold by Annulative Two‐Carbon Ring‐Expansion
D. C. Tymann, L. Benedix, L. Iovkova, R. Pallach, S. Henke, D. Tymann, M. Hiersemann*
Chem. Eur. J. 2020, 26, 11974–11978
2019
Synthesis of a Diastereomer of the Marine Macrolide Lytophilippine A
A. Klüppel, A. Gille, C. E. Karayel, M. Hiersemann*
Org. Lett. 2019, 21, 2421-2425
2018
Development of an Alkyne Analogue of the de Mayo Reaction for the Synthesis od Medium-Sized Carbacycles and Cyclohepta[b]indoles
D. Tymann, D. C. Tymann, U. Bednarzick, L. Iovkova-Berends, J. Rehbein, M. Hiersemann*
Angew. Chem. 2018, 130, 47, 15779-15783
Progress Toward the Total Synthesis of Gukulenin A: Photochemically Triggered Two-Carbon Ring Expansion Key to α-Tropolonic Ether Synthesis
D. Tymann*, U. Bednarzick, L. Iovkova-Berends, M. Hiersemann
Org. Lett. 2018, 20, 4072-4076
2017
Synthesis of Homoverrucosanoid-Derived Esters and Evaluation as MDR Modulators
A. Schäfer*, S. C. Köhler, M. Lohe, M. Wiese*, M. Hiersemann
J. Org. Chem. 2017, 82, 10504-10522
Total Synthesis and Structural Assignment of Curvicollide C
V. von Kiedrowski*, F. Quentin, M. Hiersemann*
Org. Lett. 2017, 19, 4391-4394
Synthesis of the Cyclohepta[e]hydrindane Core of the Marine Homoverrucosane Diterpenoid Gagunin E
A. Schäfer*, M. Hiersemann
Org. Lett. 2017, 19, 814-817
2014
Cyclopentanoids by Uncatalyzed Intramolecular Carbonyl Ene (ICE) Reaction of α-Keto Esters
D. Tymann*, A. Klüppel, W. Hiller, M. Hiersemann*
Org. Lett. 2014, 16, 4062-4065
Catalytic Asymmetric Claisen Rearrangement of Gosteli-Type Allyl Vinyl Ethers: Total Synthesis of (−)-9,10-Dihydro Ecklonialacetone B
J. Becker, L. Butt, V. von Kiedrowski, E. Mischler, F. Quentin, M. Hiersemann*
J. Org. Chem. 2014, 79, 3040-3051
2013
Total Synthesis of (−)-Ecklonialacetone B
J. Becker, L. Butt, V. von Kiedrowski, E. Mischler, F. Quentin, M. Hiersemann*
Org. Lett. 2013, 15, 5982-5985
2012
{1,6}-Transannular Catalytic Asymmetric Gosteli-Claisen Rearrangement
T. Jaschinski, M. Hiersemann*
Org. Lett. 2012, 14, 4114–4117
Palladium(II)-Catalyzed Cyclosiomerization of Substituted 1,5-Hexadienes: A Combined Experimental and Computational Study on an Open and an Interrupted Hydropalladation/Carbopalladation/β-Hydride Elimination (HCHe) Catalytic Cycle
B. Nelson*, S. Herres-Pawlis, W. Hiller, H. Preut, C. Strohmann, M. Hiersemann*
J. Org. Chem. 2012, 77, 4980–4995
2011
Palladium(II)-Catalyzed Cycloisomerization of Functionalized 1,5-Hexadienes
B. Nelson, W. Hiller, A. Pollex, M. Hiersemann*
Org. Lett. 2011, 13, 16, 4438–4441
Integration of Catalysis and Analysis is the Key: Rapid and Precise Investigation of the Catalytic Asymmetric Gosteli-Claisen Rearrangement
J. Troendlin, J. Rehbein, M. Hiersemann, O. Trapp*
J. Am. Chem. Soc. 2011, 133, 16444–16450
Gosteli-Claisen Rearrangement of Propargyl Vinyl Ethers: Cascading Molecular Rearrangements
A. Gille, J. Rehbein, M. Hiersemann*
Org. Lett. 2011, 13, 2122–2125
Total Synthesis of Natural and Non–Natural Jatrophane Diterpenes and their Evaluation as MDR Modulators
C. Schnabel, K. Sterz, H. Müller, J. Rehbein M. Wiese*, M. Hiersemann*
J. Org. Chem. 2011, 76, 512–522
2010
(−)-Lytophilippine A: Synthesis of a C1-C18 Building Block
A. Gille*, M. Hiersemann*
Org. Lett. 2010, 12, 5258–5261
2009
Total Synthesis of Jatrophane Diterpenes from Euphorbia characias
C. Schnabel, M. Hiersemann*
Org. Lett. 2009, 11, 2555–2558
Gosteli–Claisen Rearrangement: DFT Study of Substituent-Rate Effects
J. Rehbein, M. Hiersemann*
J. Org. Chem. 2009, 74, 4336–4342
Synthetic Studies toward Jatrophane Diterpenes from Euphorbia characias. Enantioselective Synthesis of(−)-15-O-Acetyl-3-O-propionyl-17-norcharaciol
H. Helmboldt, M. Hiersemann*
J. Org. Chem. 2009, 74, 1698–1708
Gosteli-Claisen Rearrangement: Substrate Synthesis, Simple Diastereoselectivity and Kinetic Studies
J. Rehbein*, S. Leick, M. Hiersemann*
J. Org. Chem. 2009, 74, 1531–1540
2007
Enantioselective Total Synthesis of the C8-C20 Segment of Curvicollide C
M. Körner, M. Hiersemann*
Org. Lett. 2007, 9, 4979–4982
Organocatalytic Claisen Rearrangement: Theory and Experiment
M. Kirsten, J. Rehbein T. Strassner*, M. Hiersemann*
J. Org. Chem. 2007, 72, 4001–4011
2006
Synthesis of the Norjatrophane Diterpene (−)-15-Acetyl-3-propionyl-17-norcharaciol
H. Helmboldt, D. Köhler, M. Hiersemann*
Org. Lett. 2006, 8, 1573–1576
2005
Catalytic Asymmetric Claisen Rearrangement in Natural Product Synthesis: Synthetic Studies toward (–)-Xeniolide F
A. Pollex, M. Hiersemann*
Org. Lett. 2005, 7, 5705–5708
Ester Dienolate [2,3]-Wittig Rearrangement in Natural Product Synthesis: Diastereoselective Total Synthesis of the Triester of Viridiofungin A, A2, and A4
A. Pollex, A. Millet, J. Müller, M. Hiersemann*, L. Abraham
J. Org. Chem. 2005, 70, 5579–5591
2001
The Catalytic Enantioselective Claisen Rearrangement of an Allyl Vinyl Ethers
L. Abraham, R. Czerwonka, M. Hiersemann*
Angew. Chem. Int. Ed. 2001, 40, 4700–4703
The Cu(OTf)2- and Yb(OTf)3-Catalyzed Claisen Rearrangement of 2-Alkoxycarbonyl-Substituted Allyl Vinyl Ethers
M. Hiersemann*, L. Abraham
Org. Lett. 2001, 3, 49–52
2000
Chiral Acetals as Stereoinductors: Diastereoface Selective Alkylation of Dihydrobenzoxazine-Derived Amide Enolates
J. Mulzer*, O. Langer, M. Hiersemann*, J. W. Bats, J. Buschmann, P. Luger
J. Org. Chem. 2000, 65, 6540–6546
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Location & approach
The campus of TU Dortmund University is located close to interstate junction Dortmund West, where the Sauerlandlinie A 45 (Frankfurt-Dortmund) crosses the Ruhrschnellweg B 1 / A 40. The best interstate exit to take from A 45 is "Dortmund-Eichlinghofen" (closer to Campus Süd), and from B 1 / A 40 "Dortmund-Dorstfeld" (closer to Campus Nord). Signs for the university are located at both exits. Also, there is a new exit before you pass over the B 1-bridge leading into Dortmund.
To get from Campus Nord to Campus Süd by car, there is the connection via Vogelpothsweg/Baroper Straße. We recommend you leave your car on one of the parking lots at Campus Nord and use the H-Bahn (suspended monorail system), which conveniently connects the two campuses.
TU Dortmund University has its own train station ("Dortmund Universität"). From there, suburban trains (S-Bahn) leave for Dortmund main station ("Dortmund Hauptbahnhof") and Düsseldorf main station via the "Düsseldorf Airport Train Station" (take S-Bahn number 1, which leaves every 20 or 30 minutes). The university is easily reached from Bochum, Essen, Mülheim an der Ruhr and Duisburg.
You can also take the bus or subway train from Dortmund city to the university: From Dortmund main station, you can take any train bound for the Station "Stadtgarten", usually lines U41, U45, U 47 and U49. At "Stadtgarten" you switch trains and get on line U42 towards "Hombruch". Look out for the Station "An der Palmweide". From the bus stop just across the road, busses bound for TU Dortmund University leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dortmund main station to the stop "Dortmund Kampstraße". From there, take U43 or U44 to the stop "Dortmund Wittener Straße". Switch to bus line 447 and get off at "Dortmund Universität S".
The H-Bahn is one of the hallmarks of TU Dortmund University. There are two stations on Campus Nord. One ("Dortmund Universität S") is directly located at the suburban train stop, which connects the university directly with the city of Dortmund and the rest of the Ruhr Area. Also from this station, there are connections to the "Technologiepark" and (via Campus Süd) Eichlinghofen. The other station is located at the dining hall at Campus Nord and offers a direct connection to Campus Süd every five minutes.
The AirportExpress is a fast and convenient means of transport from Dortmund Airport (DTM) to Dortmund Central Station, taking you there in little more than 20 minutes. From Dortmund Central Station, you can continue to the university campus by interurban railway (S-Bahn). A larger range of international flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the university station.
The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent "Technologiepark".
Site Map of TU Dortmund University (Second Page in English).