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Publications- Selected Articles and Letters

2020

Photochemical Approach to the Cyclohepta[b]indole Scaffold by Annulative Two‐Carbon Ring‐Expansion
D. C. Tymann, L. Benedix, L. Iovkova, R. Pallach, S. Henke, D. Tymann, M. Hiersemann*
Chem. Eur. J. 2020, 26

2019

Synthesis of a Diastereomer of the Marine Macrolide Lytophilippine A
A. Klüppel, A. Gille, C. E. Karayel, M. Hiersemann*
Org. Lett. 2019, 21, 2421-2425

2018

Development of an Alkyne Analogue of the de Mayo Reaction for the Synthesis od Medium-Sized Carbacycles and Cyclohepta[b]indoles
D. Tymann, D. C. Tymann, U. Bednarzick, L. Iovkova-Berends, J. Rehbein, M. Hiersemann*
Angew. Chem. 2018, 130, 47, 15779-15783

Progress Toward the Total Synthesis of Gukulenin A: Photochemically Triggered Two-Carbon Ring Expansion Key to α-Tropolonic Ether Synthesis
D. Tymann*, U. Bednarzick, L. Iovkova-Berends, M. Hiersemann
Org. Lett. 2018, 20, 4072-4076

2017

Synthesis of Homoverrucosanoid-Derived Esters and Evaluation as MDR Modulators
A. Schäfer*, S. C. Köhler, M. Lohe, M. Wiese*, M. Hiersemann 
J. Org. Chem. 2017, 82, 10504-10522

Total Synthesis and Structural Assignment of Curvicollide C
V. von Kiedrowski*, F. Quentin, M. Hiersemann*
Org. Lett. 2017, 19, 4391-4394

Synthesis of the Cyclohepta[e]hydrindane Core of the Marine Homoverrucosane Diterpenoid Gagunin E
A. Schäfer*, M. Hiersemann
Org. Lett. 2017, 19, 814-817

2014

Cyclopentanoids by Uncatalyzed Intramolecular Carbonyl Ene (ICE) Reaction of α-Keto Esters
D. Tymann*, A. Klüppel, W. Hiller, M. Hiersemann*
Org. Lett. 2014, 16, 4062-4065

Catalytic Asymmetric Claisen Rearrangement of Gosteli-Type Allyl Vinyl Ethers: Total Synthesis of (−)-9,10-Dihydro Ecklonialacetone B
J. Becker, L. Butt, V. von Kiedrowski, E. Mischler, F. Quentin, M. Hiersemann*
J. Org. Chem. 2014, 79, 3040-3051

2013

Total Synthesis  of (−)-Ecklonialacetone B
J. Becker, L. Butt, V. von Kiedrowski, E. Mischler, F. Quentin, M. Hiersemann*
J. Org. Lett. 2013, 15, 5982-5985

2012

{1,6}-Transannular Catalytic Asymmetric Gosteli-Claisen Rearrangement
T. Jaschinski, M. Hiersemann*
Org. Lett. 2012, 14, 4114–4117

Palladium(II)-Catalyzed Cyclosiomerization of Substituted 1,5-Hexadienes: A Combined Experimental and Computational Study on an Open and an Interrupted Hydropalladation/Carbopalladation/β-Hydride Elimination (HCHe) Catalytic Cycle
B. Nelson*, S. Herres-PawlisW. Hiller, H. Preut, C. Strohmann, M. Hiersemann*
J. Org. Chem. 2012, 77, 4980–4995

2011

Integration of Catalysis and Analysis is the Key: Rapid and Precise Investigation of the Catalytic Asymmetric Gosteli-Claisen Rearrangement
J. Troendlin, J. Rehbein, M. Hiersemann, O. Trapp
J. Am. Chem. Soc. 2011, 133, 16444–16450

Integration of Catalysis and Analysis is the Key: Rapid and Precise Investigation of the Catalytic Asymmetric Gosteli-Claisen Rearrangement
J. Troendlin, J. Rehbein, M. Hiersemann, O. Trapp
J. Am. Chem. Soc. 2011, 133, 16444–16450

Gosteli-Claisen Rearrangement of Propargyl Vinyl Ethers: Cascading Molecular Rearrangements
A. Gille, J. Rehbein, M. Hiersemann*
Org. Lett. 2011, 13, 2122–2125

Total Synthesis of Natural and Non–Natural Jatrophane Diterpenes and their Evaluation as MDR Modulators
C. Schnabel, K. Sterz, H. Müller, J. Rehbein M. Wiese*, M. Hiersemann*
J. Org. Chem. 2011, 76, 512–522

2010

(−)-Lytophilippine A: Synthesis of a C1-C18 Building Block
A. Gille*, M. Hiersemann*
Org. Lett. 2010, 12, 5258–5261

2009

Total Synthesis of Jatrophane Diterpenes from Euphorbia characias
C. Schnabel, M. Hiersemann*
Org. Lett., 2009, 11, 2555–2558

Gosteli–Claisen Rearrangement: DFT Study of Substituent-Rate Effects
J. Rehbein, M. Hiersemann*
J. Org. Chem. 2009, 74, 4336–4342

Synthetic Studies toward Jatrophane Diterpenes from Euphorbia characias. Enantioselective Synthesis of(−)-15-O-Acetyl-3-O-propionyl-17-norcharaciol
H. Helmboldt, M. Hiersemann*
J. Org. Chem., 2009, 74, 1698–1708

Gosteli-Claisen Rearrangement: Substrate Synthesis, Simple Diastereoselectivity and Kinetic Studies
J. Rehbein*, S. Leick, M. Hiersemann*
J. Org. Chem. 2009, 74, 1531–1540

2007

Enantioselective Total Synthesis of the C8-C20 Segment of Curvicollide C
M. Körner, M. Hiersemann*
Org. Lett. 2007, 9, 4979–4982

Organocatalytic Claisen Rearrangement: Theory and Ex­peri­ment
M. Kirsten, J. Rehbein T. Strassner*, M. Hiersemann*
J. Org. Chem. 2007, 72, 4001–4011

2006

Synthesis of the Norjatrophane Diterpene (−)-15-Acetyl-3-propionyl-17-norcharaciol
H. Helmboldt, D. Köhler, M. Hiersemann*
Org. Lett. 2006, 8, 1573–1576

2005

Catalytic Asymmetric Claisen Rearrangement in Natural Product Synthesis: Synthetic Studies toward (–)-Xeniolide F
A. Pollex, M. Hiersemann*
Org. Lett. 2005, 7, 5705–5708

Ester Dienolate [2,3]-Wittig Rearrangement in Natural Product Synthesis: Diastereoselective Total Synthesis of the Triester of Viridiofungin A, A2, and A4
A. Pollex, A. Millet, J. Müller, M. Hiersemann*, L. Abraham
J. Org. Chem. 2005, 70, 5579–5591

2001

The Catalytic Enantioselective Claisen Rearrangement of an Allyl Vinyl Ethers
L. Abraham, R. Czerwonka, M. Hiersemann*
Angew. Chem. Int. Ed. 2001, 40, 4700–4703

The Cu(OTf)2- and Yb(OTf)3-Catalyzed Claisen Rearrangement of 2-Alkoxycarbonyl-Substituted Allyl Vinyl Ethers
M. Hiersemann*, L. Abraham
Org. Lett. 2001, 3, 49–52

2000

Chiral Acetals as Stereoinductors: Diastereoface Selective Alkylation of Dihydrobenzoxazine-Derived Amide Enolates
J. Mulzer*, O. Langer, M. Hiersemann*, J. W. Bats, J. Buschmann, P. Luger
J. Org. Chem. 2000, 65, 6540–6546

Location & approach

The campus of TU Dort­mund University is located close to interstate junction Dort­mund West, where the Sauerlandlinie A 45 (Frankfurt-Dort­mund) crosses the Ruhrschnellweg B 1 / A 40. The best interstate exit to take from A 45 is "Dort­mund-Eichlinghofen" (closer to Campus Süd), and from B 1 / A 40 "Dort­mund-Dorstfeld" (closer to Campus Nord). Signs for the uni­ver­si­ty are located at both exits. Also, there is a new exit before you pass over the B 1-bridge leading into Dort­mund.

To get from Campus Nord to Campus Süd by car, there is the connection via Vogelpothsweg/Baroper Straße. We recommend you leave your car on one of the parking lots at Campus Nord and use the H-Bahn (suspended monorail system), which conveniently connects the two campuses.

TU Dort­mund University has its own train station ("Dort­mund Uni­ver­si­tät"). From there, suburban trains (S-Bahn) leave for Dort­mund main station ("Dort­mund Hauptbahnhof") and Düsseldorf main station via the "Düsseldorf Airport Train Station" (take S-Bahn number 1, which leaves every 20 or 30 minutes). The uni­ver­si­ty is easily reached from Bochum, Essen, Mülheim an der Ruhr and Duisburg.

You can also take the bus or subway train from Dort­mund city to the uni­ver­si­ty: From Dort­mund main station, you can take any train bound for the Station "Stadtgarten", usually lines U41, U45, U 47 and U49. At "Stadtgarten" you switch trains and get on line U42 towards "Hombruch". Look out for the Station "An der Palmweide". From the bus stop just across the road, busses bound for TU Dort­mund University leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dort­mund main station to the stop "Dort­mund Kampstraße". From there, take U43 or U44 to the stop "Dort­mund Wittener Straße". Switch to bus line 447 and get off at "Dort­mund Uni­ver­si­tät S".

The H-Bahn is one of the hallmarks of TU Dort­mund University. There are two stations on Campus Nord. One ("Dort­mund Uni­ver­si­tät S") is directly located at the suburban train stop, which connects the uni­ver­si­ty directly with the city of Dort­mund and the rest of the Ruhr Area. Also from this station, there are connections to the "Technologiepark" and (via Campus Süd) Eichlinghofen. The other station is located at the dining hall at Campus Nord and offers a direct connection to Campus Süd every five minutes.

The AirportExpress is a fast and convenient means of transport from Dort­mund Airport (DTM) to Dort­mund Central Station, taking you there in little more than 20 minutes. From Dort­mund Central Station, you can continue to the uni­ver­si­ty campus by interurban railway (S-Bahn). A larger range of in­ter­na­tio­nal flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the uni­ver­si­ty station.

The facilities of TU Dort­mund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the uni­ver­si­ty are located in the adjacent "Technologiepark".

Site Map of TU Dort­mund University (Second Page in English).