Research
Bringing Chemistry to Life
The Rauh group focuses on chemical biology, protein X-ray crystallography and medicinal chemistry research. We employ organic synthesis, structural biology, structure-based ligand design, biochemical and cellular compound screening, as well as target identification for the development of inhibitors and functional probes to target proteins with relevance to cancer.
Over the last decade, the Rauh group has collaborated very successfully with oncologists from university hospitals throughout NRW on translational aspects of acquired drug resistance in lung cancer and pioneered the field of chemical oncology.
We developed the widely applicable FLiK technologies (Fluorescent Labels in Kinases), which allow for the identification and characterization of allosteric kinase modulators from compound libraries in high-throughput. The Rauh Lab has established a Robotics Assisted Screening Platform for Efficient Ligand Discovery (RASPELD) that can be utilized for a variety of screening campaigns.
Prof. Daniel Rauh is co-founder of the Zentrum für integrierte Wirkstoffforschung (ZIW) and coordinates the “Drug Discovery Hub Dortmund” (DDHD) at TU Dortmund University, which translates basic academic research into pharmaceutical application.
The TU Dortmund University centrally leads and coordinates the Drug Discovery Hub Dortmund (DDHD) at the „Zentrum für integrierte Wirkstoffforschung“ (ZIW). The DDHD is an EFRE-funded consortium consisting of partners from both academia and industry with the primary objective of translating basic academic research into pharmaceutical application.
Within the framework of “KomIT - Center of Competence for Innovative Diabetes Therapy” (https://komit-nrw.de/ - implement as hyperlink), the DDHD will contribute by scouting for innovative research projects and follow-up studies that focus on diabetes-related indications and comply with the criteria of feasibility, patent situation, and potential for a joint validation and refinement.
The KomIT research platform is conducting proof-of-concept studies aiming to optimize both the different modules of the infrastructure and to generate new knowledge on the beta-cell protective function modulating relevant receptor target upon ligand binding. This research is driven by recent findings of potential beta-cell replacement in response to pharmacological treatment in animal models.
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Location & approach
The campus of TU Dortmund University is located close to interstate junction Dortmund West, where the Sauerlandlinie A 45 (Frankfurt-Dortmund) crosses the Ruhrschnellweg B 1 / A 40. The best interstate exit to take from A 45 is "Dortmund-Eichlinghofen" (closer to Campus Süd), and from B 1 / A 40 "Dortmund-Dorstfeld" (closer to Campus Nord). Signs for the university are located at both exits. Also, there is a new exit before you pass over the B 1-bridge leading into Dortmund.
To get from Campus Nord to Campus Süd by car, there is the connection via Vogelpothsweg/Baroper Straße. We recommend you leave your car on one of the parking lots at Campus Nord and use the H-Bahn (suspended monorail system), which conveniently connects the two campuses.
TU Dortmund University has its own train station ("Dortmund Universität"). From there, suburban trains (S-Bahn) leave for Dortmund main station ("Dortmund Hauptbahnhof") and Düsseldorf main station via the "Düsseldorf Airport Train Station" (take S-Bahn number 1, which leaves every 20 or 30 minutes). The university is easily reached from Bochum, Essen, Mülheim an der Ruhr and Duisburg.
You can also take the bus or subway train from Dortmund city to the university: From Dortmund main station, you can take any train bound for the Station "Stadtgarten", usually lines U41, U45, U 47 and U49. At "Stadtgarten" you switch trains and get on line U42 towards "Hombruch". Look out for the Station "An der Palmweide". From the bus stop just across the road, busses bound for TU Dortmund University leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dortmund main station to the stop "Dortmund Kampstraße". From there, take U43 or U44 to the stop "Dortmund Wittener Straße". Switch to bus line 447 and get off at "Dortmund Universität S".
The H-Bahn is one of the hallmarks of TU Dortmund University. There are two stations on Campus Nord. One ("Dortmund Universität S") is directly located at the suburban train stop, which connects the university directly with the city of Dortmund and the rest of the Ruhr Area. Also from this station, there are connections to the "Technologiepark" and (via Campus Süd) Eichlinghofen. The other station is located at the dining hall at Campus Nord and offers a direct connection to Campus Süd every five minutes.
The AirportExpress is a fast and convenient means of transport from Dortmund Airport (DTM) to Dortmund Central Station, taking you there in little more than 20 minutes. From Dortmund Central Station, you can continue to the university campus by interurban railway (S-Bahn). A larger range of international flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the university station.
The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent "Technologiepark".
Site Map of TU Dortmund University (Second Page in English).