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Research

Bringing Chem­is­try to Life

The Rauh group focuses on chemical biology, protein X-ray crystallography and medicinal chem­is­try re­search. We employ organic synthesis, structural biology, structure-based ligand de­sign, biochemical and cellular compound screening, as well as target identification for the development of inhibitors and functional probes to target proteins with relevance to cancer.

Over the last decade, the Rauh group has collaborated very successfully with oncologists from uni­ver­si­ty hospitals throughout NRW on translational aspects of acquired drug resistance in lung cancer and pioneered the field of chemical oncology.

We developed the widely applicable FLiK technologies (Fluorescent Labels in Kinases), which allow for the identification and characterization of allosteric kinase modulators from compound libraries in high-throughput. The Rauh Lab has established a Robotics Assisted Screening Platform for Efficient Ligand Discovery (RASPELD) that can be utilized for a variety of screening campaigns.

Prof. Daniel Rauh is co-founder of the Zen­trum für integrierte Wirkstoffforschung (ZIW) and coordinates the “Drug Discovery Hub Dort­mund” (DDHD) at TU Dort­mund Uni­ver­sity, which translates basic academic re­search into pharmaceutical application.

The TU Dort­mund Uni­ver­sity centrally leads and coordinates the Drug Discovery Hub Dort­mund (DDHD) at the „Zen­trum für integrierte Wirkstoffforschung“ (ZIW). The DDHD is an EFRE-funded con­sor­tium consisting of partners from both academia and industry with the primary objective of translating basic academic re­search into pharmaceutical application.

Dortmund Skyline inkl. DDHD-Logo, EFRE-Förderhinweisen und Verbundpartner © RauhLab​/​TU Dort­mund

Within the frame­work of “KomIT - Center of Competence for In­no­va­tive Diabetes Therapy” (https://komit-nrw.de/ - implement as hyperlink), the DDHD will contribute by scouting for in­no­va­ti­ve re­search projects and follow-up studies that focus on diabetes-related indications and comply with the criteria of feasibility, patent situation, and potential for a joint validation and refinement.

The KomIT re­search platform is conducting proof-of-concept studies aiming to optimize both the different modules of the infra­structure and to generate new knowledge on the beta-cell protective function modulating relevant receptor target upon ligand binding. This re­search is driven by recent findings of potential beta-cell replacement in response to pharmacological treatment in animal models.

DDZ-Logo und EFRE-Förderhinweise © DDZ

Location & approach

The campus of TU Dort­mund Uni­ver­sity is located close to interstate junction Dort­mund West, where the Sauerlandlinie A 45 (Frankfurt-Dort­mund) crosses the Ruhrschnellweg B 1 / A 40. The best interstate exit to take from A 45 is "Dort­mund-Eichlinghofen" (closer to Campus Süd), and from B 1 / A 40 "Dort­mund-Dorstfeld" (closer to Campus Nord). Signs for the uni­ver­si­ty are located at both exits. Also, there is a new exit before you pass over the B 1-bridge leading into Dort­mund.

To get from Campus Nord to Campus Süd by car, there is the connection via Vo­gel­pothsweg/Baroper Straße. We recommend you leave your car on one of the parking lots at Campus Nord and use the H-Bahn (suspended monorail system), which conveniently connects the two campuses.

TU Dort­mund Uni­ver­sity has its own train station ("Dort­mund Uni­ver­si­tät"). From there, suburban trains (S-Bahn) leave for Dort­mund main station ("Dort­mund Hauptbahnhof") and Düsseldorf main station via the "Düsseldorf Airport Train Station" (take S-Bahn number 1, which leaves every 20 or 30 minutes). The uni­ver­si­ty is easily reached from Bochum, Essen, Mülheim an der Ruhr and Duisburg.

You can also take the bus or subway train from Dort­mund city to the uni­ver­si­ty: From Dort­mund main station, you can take any train bound for the Station "Stadtgarten", usually lines U41, U45, U 47 and U49. At "Stadtgarten" you switch trains and get on line U42 towards "Hombruch". Look out for the Station "An der Palmweide". From the bus stop just across the road, busses bound for TU Dort­mund Uni­ver­sity leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dort­mund main station to the stop "Dort­mund Kampstraße". From there, take U43 or U44 to the stop "Dort­mund Wittener Straße". Switch to bus line 447 and get off at "Dort­mund Uni­ver­si­tät S".

The H-Bahn is one of the hallmarks of TU Dort­mund Uni­ver­sity. There are two stations on Campus Nord. One ("Dort­mund Uni­ver­si­tät S") is directly located at the suburban train stop, which connects the uni­ver­si­ty directly with the city of Dort­mund and the rest of the Ruhr Area. Also from this station, there are connections to the "Technologiepark" and (via Campus Süd) Eichlinghofen. The other station is located at the dining hall at Campus Nord and offers a direct connection to Campus Süd every five minutes.

The AirportExpress is a fast and convenient means of transport from Dort­mund Airport (DTM) to Dort­mund Central Station, taking you there in little more than 20 minutes. From Dort­mund Central Station, you can continue to the uni­ver­si­ty campus by interurban railway (S-Bahn). A larger range of in­ter­na­tio­nal flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the uni­ver­si­ty station.

The facilities of TU Dort­mund Uni­ver­sity are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the uni­ver­si­ty are located in the adjacent "Technologiepark".

Site Map of TU Dort­mund Uni­ver­sity (Second Page in English).