Teaching
I have established a lecture series on the Science of Synthesis (Synthesewissenschaft) that aims to teach students about available and valuable methods for selective structural manipulation of organic molecules. The course illustrates opportunities and illuminates limitations of the currently available synthetic methodology. I will outline ways and means – tactics and strategies – for the selective structural manipulation of structurally complex molecules with relevance to medicinal chemistry, materials chemistry, and natural product chemistry. To (pre)serve the purpose, my lecture series is based exclusively on examples from the contemporary original literature. By design, relevance with respect to the current state of the art is thus secured. The lecture series doesn’t shy away from the unexpected or the unexplainable experimental results nor from the exceptions from the rule. Hence, the lecture series was not designed to hide but rather to introduce to intellectual ambiguities in this field of research. For more information, please visit Moodle of the TU Dortmund.
"Einführung in die Synthesewissenschaften (MOC2V)"
(1) radikalische Substitution am sp3-Kohlenstoffatom I; (2) radikalische Substitution am sp3-Kohlenstoffatom II; (3) nucleophile Substitution am sp3-Kohlenstoffatom I; (4) nucleophile Substitution am sp3-Kohlenstoffatom II; (5) 1,2-Eliminierung zu C/C-Doppelbindungen; (6) Addition an C/C-Mehrfachbindungen; (7) Substitution am Aromaten I; (8) Substitution am Aromaten II; (9) Reduktion von Carbonylverbindungen; (10) Oxidation am Kohlenstoffatom; (11) nucleophile Substitution am Carbonylkohlenstoffatom; (11) Acetale, Imine, Enamine, Oxime, Hydrazone; (12) Enole; Mannich-Reaktion; Enolate; (13) Enolate; Aldolreaktion; (15) Claisen-, Dieckmann-, Knoevenagel-Kondensation; (16) Enolate: Alkylierung; Michael-Addition; (17) metallorganische Verbindungen; Magnesiumorganyle; (18) Lithiumorganyle; (19) Phosphororganyle: Wittig-Reaktion; (20) Palladium-katalysierte C/C-Bindungsbildungsprozesse: Heck-Reaktion; Kreuzkupplungen; (21) Ruthenium-katalysierte C/C-Bindungsbildung: Ringschlussolefinmetathese; (22) Einführung in die statische Stereochemie; (23) Synthese und Selektivität; stereodifferenzierende Synthese; (24) Methoden der asymmetrischen Synthese I; (25) Methoden der asymmetrischen Synthese II; (26) Carbonsäureaktivierung; (27) perizyklische Reaktionen I; (28) perizyklische Reaktionen II; (29) Naturstoffe I; (30) Naturstoffe II
"Einführung in die Synthesewissenschaften (MOC2V)"
(1) radikalische Substitution am sp3-Kohlenstoffatom I; (2) radikalische Substitution am sp3-Kohlenstoffatom II; (3) nucleophile Substitution am sp3-Kohlenstoffatom I; (4) nucleophile Substitution am sp3-Kohlenstoffatom II; (5) 1,2-Eliminierung zu C/C-Doppelbindungen; (6) Addition an C/C-Mehrfachbindungen; (7) Substitution am Aromaten I; (8) Substitution am Aromaten II; (9) Reduktion von Carbonylverbindungen; (10) Oxidation am Kohlenstoffatom; (11) nucleophile Substitution am Carbonylkohlenstoffatom; (11) Acetale, Imine, Enamine, Oxime, Hydrazone; (12) Enole; Mannich-Reaktion; Enolate; (13) Enolate; Aldolreaktion; (15) Claisen-, Dieckmann-, Knoevenagel-Kondensation; (16) Enolate: Alkylierung; Michael-Addition; (17) metallorganische Verbindungen; Magnesiumorganyle; (18) Lithiumorganyle; (19) Phosphororganyle: Wittig-Reaktion; (20) Palladium-katalysierte C/C-Bindungsbildungsprozesse: Heck-Reaktion; Kreuzkupplungen; (21) Ruthenium-katalysierte C/C-Bindungsbildung: Ringschlussolefinmetathese; (22) Einführung in die statische Stereochemie; (23) Synthese und Selektivität; stereodifferenzierende Synthese; (24) Methoden der asymmetrischen Synthese I; (25) Methoden der asymmetrischen Synthese II; (26) Carbonsäureaktivierung; (27) perizyklische Reaktionen I; (28) perizyklische Reaktionen II; (29) Naturstoffe I; (30) Naturstoffe II
"Synthesewissenschaften I"
(1) radikalische C/C-Bindungsbildung; (2) nucleophile Substitution am sp3-Kohlenstoffatom; (3) Übergangsmetall-katalysierte Substitutionen am Aromaten; (4) Synthese von C/C-Mehrfachbindungen durch Kondensationsreaktionen; (5) Lithiumorganyle; (6) Aldoladditionen unter asymmetrischer Induktion I; (7) Aldoladditionen unter asymmetrischer Induktion II; (8) Palladium-katalysierte C/C-Bindungsbildungsprozesse; (9) Metathese mit Rutheniumcarbenkomplexen I; (10) Metathese mit Rutheniumcarbenkomplexen II; (11) Kettenverlängerung, Ringexpansion und Ringkontraktion durch nucleophile [1,2]-Umlagerungen; (12) Claisen-Umlagerungen; (13) Diels−Alder-Zykloadditionen; (14) elektrophile Additionen an C/C-Doppelbindungen; (15) Fotochemie
"Synthesewissenschaften II"
(1) radikalische C/C-Bindungsbildung; (2) Palladium-katalysierte C/C-Bindungsbildungsprozesse; (3) Dreiringsynthese: Zyklopropanierung; (4) Fünfringsynthese: Pauson–Khand-Reaktion; (5) Fünfringsynthese: Nazarov-Zyklisierung; (6) Fünf- und Sechsringsynthese: intramolekulare Aldol-Kondensation, Robinson-Annelierung und Hajos−Parrish-Reaktion; (7) Siebenringsynthese: Cope-Umlagerung; (8) Siebenringsynthese: Rhodium(I)-katalysierte intramolekulare (5+2)-Zykloaddition; (9) Pyrroldinsynthese durch 1,3-dipolare Zykloadditionen mit Azomethinyliden; (10) 1,2-Oxazolidinsynthese und Zugang zu γ-Aminoalkoholen durch 1,3-dipolare Zykloadditionen mit Nitronen; (11) nucleophile 1,2-Umlagerungen zum Stickstoffatom; (12) C(sp3)−H-Oxidation; (13) Fotoredoxkatalyse
"Synthesewissenschaften III"
(1) radikalische C/C-Bindungsbildung; (2) Achmatowicz-Reaktion; (3) Fischer-Indolsynthese; (4) Pictet−Spengler-Reaktion, Bischler−Napieralski-Reaktion; (5) Pinakol- und Semipinakol-Umlagerungen; (6) Knoevenagel-Kondensation; (7) Dieckmann-Kondensation; (8) Mannich-Reaktion; (9) Nicholas-Reaktion; (10) C/C-Bindungsbildung durch C(sp3)−H-Insertion; (11) Zyklisierungskaskaden I; (12) Zyklisierungskaskaden II; (13) Fotochemie
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Location & approach
The campus of TU Dortmund University is located close to interstate junction Dortmund West, where the Sauerlandlinie A 45 (Frankfurt-Dortmund) crosses the Ruhrschnellweg B 1 / A 40. The best interstate exit to take from A 45 is "Dortmund-Eichlinghofen" (closer to Campus Süd), and from B 1 / A 40 "Dortmund-Dorstfeld" (closer to Campus Nord). Signs for the university are located at both exits. Also, there is a new exit before you pass over the B 1-bridge leading into Dortmund.
To get from Campus Nord to Campus Süd by car, there is the connection via Vogelpothsweg/Baroper Straße. We recommend you leave your car on one of the parking lots at Campus Nord and use the H-Bahn (suspended monorail system), which conveniently connects the two campuses.
TU Dortmund University has its own train station ("Dortmund Universität"). From there, suburban trains (S-Bahn) leave for Dortmund main station ("Dortmund Hauptbahnhof") and Düsseldorf main station via the "Düsseldorf Airport Train Station" (take S-Bahn number 1, which leaves every 20 or 30 minutes). The university is easily reached from Bochum, Essen, Mülheim an der Ruhr and Duisburg.
You can also take the bus or subway train from Dortmund city to the university: From Dortmund main station, you can take any train bound for the Station "Stadtgarten", usually lines U41, U45, U 47 and U49. At "Stadtgarten" you switch trains and get on line U42 towards "Hombruch". Look out for the Station "An der Palmweide". From the bus stop just across the road, busses bound for TU Dortmund University leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dortmund main station to the stop "Dortmund Kampstraße". From there, take U43 or U44 to the stop "Dortmund Wittener Straße". Switch to bus line 447 and get off at "Dortmund Universität S".
The H-Bahn is one of the hallmarks of TU Dortmund University. There are two stations on Campus Nord. One ("Dortmund Universität S") is directly located at the suburban train stop, which connects the university directly with the city of Dortmund and the rest of the Ruhr Area. Also from this station, there are connections to the "Technologiepark" and (via Campus Süd) Eichlinghofen. The other station is located at the dining hall at Campus Nord and offers a direct connection to Campus Süd every five minutes.
The AirportExpress is a fast and convenient means of transport from Dortmund Airport (DTM) to Dortmund Central Station, taking you there in little more than 20 minutes. From Dortmund Central Station, you can continue to the university campus by interurban railway (S-Bahn). A larger range of international flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the university station.
The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent "Technologiepark".
Site Map of TU Dortmund University (Second Page in English).