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Teaching

I have established a lecture series on the Science of Synthesis (Synthesewissenschaft) that aims to teach students about available and valuable methods for selective structural manipulation of organic mol­ecules. The course illustrates opportunities and illuminates limitations of the currently available synthetic methodology. I will outline ways and means – tactics and strategies – for the selective structural manipulation of structurally complex mol­ecules with relevance to medicinal chem­is­try, materials chem­is­try, and natural product chem­is­try. To (pre)serve the purpose, my lecture series is based exclusively on examples from the contemporary original literature. By de­sign, relevance with respect to the current state of the art is thus secured. The lecture series doesn’t shy away from the unexpected or the unexplainable experimental results nor from the exceptions from the rule. Hence, the lecture series was not designed to hide but rather to introduce to intellectual ambiguities in this field of re­search. For more in­for­mation, please visit Moodle of the TU Dort­mund.

"Einführung in die Synthesewissenschaften (MOC2V)"

(1) radikalische Substitution am sp3-Kohlenstoffatom I; (2) radikalische Substitution am sp3-Kohlenstoffatom II; (3) nucleophile Substitution am sp3-Kohlenstoffatom I; (4) nucleophile Substitution am sp3-Kohlenstoffatom II; (5) 1,2-Eliminierung zu C/C-Doppelbindungen; (6) Addition an C/C-Mehrfachbindungen; (7) Substitution am Aromaten I; (8) Substitution am Aromaten II; (9) Reduktion von Carbonylverbindungen; (10) Oxidation am Kohlenstoffatom; (11) nucleophile Substitution am Carbonylkohlenstoffatom; (11) Acetale, Imine, Enamine, Oxime, Hydrazone; (12) Enole; Mannich-Reaktion; Enolate; (13) Enolate; Aldolreaktion; (15) Claisen-, Dieckmann-, Knoevenagel-Kondensation; (16) Enolate: Alkylierung; Michael-Addition; (17) metallorganische Verbindungen; Magnesiumorganyle; (18) Lithiumorganyle; (19) Phosphororganyle: Wittig-Reaktion; (20) Palladium-katalysierte C/C-Bindungsbildungsprozesse: Heck-Reaktion; Kreuzkupplungen; (21) Ruthenium-katalysierte C/C-Bindungsbildung: Ringschlussolefinmetathese; (22) Einführung in die statische Stereochemie; (23) Synthese und Selektivität; stereodifferenzierende Synthese; (24) Me­tho­den der asymmetrischen Synthese I; (25) Me­tho­den der asymmetrischen Synthese II; (26) Carbonsäureaktivierung; (27) perizyklische Reaktionen I; (28) perizyklische Reaktionen II; (29) Naturstoffe I; (30) Naturstoffe II

"Einführung in die Synthesewissenschaften (MOC2V)"

(1) radikalische Substitution am sp3-Kohlenstoffatom I; (2) radikalische Substitution am sp3-Kohlenstoffatom II; (3) nucleophile Substitution am sp3-Kohlenstoffatom I; (4) nucleophile Substitution am sp3-Kohlenstoffatom II; (5) 1,2-Eliminierung zu C/C-Doppelbindungen; (6) Addition an C/C-Mehrfachbindungen; (7) Substitution am Aromaten I; (8) Substitution am Aromaten II; (9) Reduktion von Carbonylverbindungen; (10) Oxidation am Kohlenstoffatom; (11) nucleophile Substitution am Carbonylkohlenstoffatom; (11) Acetale, Imine, Enamine, Oxime, Hydrazone; (12) Enole; Mannich-Reaktion; Enolate; (13) Enolate; Aldolreaktion; (15) Claisen-, Dieckmann-, Knoevenagel-Kondensation; (16) Enolate: Alkylierung; Michael-Addition; (17) metallorganische Verbindungen; Magnesiumorganyle; (18) Lithiumorganyle; (19) Phosphororganyle: Wittig-Reaktion; (20) Palladium-katalysierte C/C-Bindungsbildungsprozesse: Heck-Reaktion; Kreuzkupplungen; (21) Ruthenium-katalysierte C/C-Bindungsbildung: Ringschlussolefinmetathese; (22) Einführung in die statische Stereochemie; (23) Synthese und Selektivität; stereodifferenzierende Synthese; (24) Me­tho­den der asymmetrischen Synthese I; (25) Me­tho­den der asymmetrischen Synthese II; (26) Carbonsäureaktivierung; (27) perizyklische Reaktionen I; (28) perizyklische Reaktionen II; (29) Naturstoffe I; (30) Naturstoffe II

"Synthesewissenschaften I"

(1) radikalische C/C-Bindungsbildung; (2) nucleophile Substitution am sp3-Kohlenstoffatom; (3) Übergangsmetall-katalysierte Substitutionen am Aromaten; (4) Synthese von C/C-Mehrfachbindungen durch Kondensationsreaktionen; (5) Lithiumorganyle; (6) Aldoladditionen unter asymmetrischer Induktion I; (7) Aldoladditionen unter asymmetrischer Induktion II; (8) Palladium-katalysierte C/C-Bindungsbildungsprozesse; (9) Metathese mit Rutheniumcarbenkomplexen I; (10) Metathese mit Rutheniumcarbenkomplexen II; (11) Kettenverlängerung, Ringexpansion und Ringkontraktion durch nucleophile [1,2]-Umlagerungen; (12) Claisen-Umlagerungen; (13) Diels−Alder-Zykloadditionen; (14) elektrophile Additionen an C/C-Doppelbindungen; (15) Fotochemie

"Synthesewissenschaften II"

(1) radikalische C/C-Bindungsbildung; (2) Palladium-katalysierte C/C-Bindungsbildungsprozesse; (3) Dreiringsynthese: Zyklopropanierung; (4) Fünfringsynthese: Pauson–Khand-Reaktion; (5) Fünfringsynthese: Nazarov-Zyklisierung; (6) Fünf- und Sechsringsynthese: intramolekulare Aldol-Kondensation, Robinson-Annelierung und Hajos−Parrish-Reaktion; (7) Siebenringsynthese: Cope-Umlagerung; (8) Siebenringsynthese: Rhodium(I)-katalysierte intramolekulare (5+2)-Zykloaddition; (9) Pyrroldinsynthese durch 1,3-dipolare Zykloadditionen mit Azomethinyliden; (10) 1,2-Oxazolidinsynthese und Zugang zu γ-Aminoalkoholen durch 1,3-dipolare Zykloadditionen mit Nitronen; (11) nucleophile 1,2-Umlagerungen zum Stickstoffatom; (12) C(sp3)−H-Oxidation; (13) Fotoredoxkatalyse

"Synthesewissenschaften III"

(1) radikalische C/C-Bindungsbildung; (2) Achmatowicz-Reaktion; (3) Fischer-Indolsynthese; (4) Pictet−Spengler-Reaktion, Bischler−Napieralski-Reaktion; (5) Pinakol- und Semipinakol-Umlagerungen; (6) Knoevenagel-Kondensation; (7) Dieckmann-Kondensation; (8) Mannich-Reaktion; (9) Nicholas-Reaktion; (10) C/C-Bindungsbildung durch C(sp3)−H-Insertion; (11) Zyklisierungskaskaden I; (12) Zyklisierungskaskaden II; (13) Fotochemie

Location & approach

The campus of TU Dort­mund Uni­ver­sity is located close to interstate junction Dort­mund West, where the Sauerlandlinie A 45 (Frankfurt-Dort­mund) crosses the Ruhrschnellweg B 1 / A 40. The best interstate exit to take from A 45 is "Dort­mund-Eichlinghofen" (closer to Cam­pus Süd), and from B 1 / A 40 "Dort­mund-Dorstfeld" (closer to Cam­pus Nord). Signs for the uni­ver­si­ty are located at both exits. Also, there is a new exit before you pass over the B 1-bridge leading into Dort­mund.

To get from Cam­pus Nord to Cam­pus Süd by car, there is the connection via Vo­gel­pothsweg/Baroper Straße. We recommend you leave your car on one of the parking lots at Cam­pus Nord and use the H-Bahn (suspended monorail system), which conveniently connects the two campuses.

TU Dort­mund Uni­ver­sity has its own train station ("Dort­mund Uni­ver­si­tät"). From there, suburban trains (S-Bahn) leave for Dort­mund main station ("Dort­mund Hauptbahnhof") and Düsseldorf main station via the "Düsseldorf Airport Train Station" (take S-Bahn number 1, which leaves every 20 or 30 minutes). The uni­ver­si­ty is easily reached from Bochum, Essen, Mülheim an der Ruhr and Duis­burg.

You can also take the bus or subway train from Dort­mund city to the uni­ver­si­ty: From Dort­mund main station, you can take any train bound for the Station "Stadtgarten", usually lines U41, U45, U 47 and U49. At "Stadtgarten" you switch trains and get on line U42 towards "Hombruch". Look out for the Station "An der Palmweide". From the bus stop just across the road, busses bound for TU Dort­mund Uni­ver­sity leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dort­mund main station to the stop "Dort­mund Kampstraße". From there, take U43 or U44 to the stop "Dort­mund Wittener Straße". Switch to bus line 447 and get off at "Dort­mund Uni­ver­si­tät S".

The H-Bahn is one of the hallmarks of TU Dort­mund Uni­ver­sity. There are two stations on Cam­pus Nord. One ("Dort­mund Uni­ver­si­tät S") is directly located at the suburban train stop, which connects the uni­ver­si­ty directly with the city of Dort­mund and the rest of the Ruhr Area. Also from this station, there are connections to the "Technologiepark" and (via Cam­pus Süd) Eichlinghofen. The other station is located at the dining hall at Cam­pus Nord and offers a direct connection to Cam­pus Süd every five minutes.

The AirportExpress is a fast and convenient means of transport from Dort­mund Airport (DTM) to Dort­mund Central Station, taking you there in little more than 20 minutes. From Dort­mund Central Station, you can continue to the uni­ver­si­ty campus by interurban railway (S-Bahn). A larger range of in­ter­na­tio­nal flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the uni­ver­si­ty station.

The facilities of TU Dort­mund Uni­ver­sity are spread over two campuses, the larger Cam­pus North and the smaller Cam­pus South. Additionally, some areas of the uni­ver­si­ty are located in the adjacent "Technologiepark".

Site Map of TU Dort­mund Uni­ver­sity (Second Page in English).