Publications
2024
Galanti L, Peritore M, Gnügge R, Cannavo E, Heipke J, Palumbieri MD, Steigenberger B, Symington LS, Cejka P, Pfander B.
Dbf4-dependent kinase promotes cell cycle controlled resection of DNA double-strand breaks and repair by homologous recombination.
Nat Commun. 2024 Apr 3;15(1):2890. doi: 10.1038/s41467-024-46951-z. PMID: 38570537; PMCID: PMC10991553.
2023
* corresponding author, # equal contribution
Karl LA, Galanti L, Bantele SCS, Metzner F, Safaric B, Rajappa L, Foster B, Borges Pires V, Bansal P, Chacin E, Basquin J, Duderstadt KE, Kurat CF, Bartke T, Hopfner KP, Pfander B* (2023).
A SAM-key domain required for enzymatic activty of the Fun30 nucleosome remodeller.
Life Sci Alliance. 6(9), doi: 10.26508/lsa.202201790.
Chacin E, Reusswig KU, Furmeier J, Bansal P, Karl LA, Pfander B, Straub T, Korber P, Kurat CF* (2023).
Establishment and function of chromatin organization at replication origins.
Nature. 616(7958), 836-842, doi: 10.1038/s41586-023-05926-8.
2022
Kunert F, Metzner FJ, Jung J, Höpfler M, Woike S, Schall K, Kostrewa D, Moldt M, Chen JX, Bantele S, Pfander B, Eustermann S, Hopfner KP* (2022).
Structural mechanism of extranucleosomal DNA readout by the INO80 complex.
Sci Advances. 8(49), doi: 10.1126/sciadv.add3189.
Reusswig KU, Bittmann J, Peritore M, Courtes M, Pardo B, Wierer M, Mann M, Pfander B* (2022).
Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions.
Nat Commun. 13, doi: 10.1038/s41467-022-34379-2.
Karl LA#, Peritore M#, Galanti L#, Pfander B* (2022).
DNA Double Strand Break Repair and Its Control by Nucleosome Remodeling.
Front Genet. doi: 10.3389/fgene.2021.821543.
2021
Chacin E, Bansal P, Reusswig KU, Diaz-Santin LM, Ortega P, Vizjak P, Gomez-Gonzales B, Müller-Planitz F, Aguilera A, Pfander B, Cheung ACM, Kurat CF* (2021).
A CDK-regulated chromatin segregase involved in chromosome replication.
Nat Commun.12, doi: 10.1038/s41467-021-25424-7.
Peritore M, Reusswig KU, Bantele S, Straub T, Pfander B*. (2021).
Strand-specific ChIP-seq at DNA breaks distinguishes single versus double-stranded DNA binding and refutes single-stranded nucleosomes.
Mol Cell. 81(1), 1-13 doi: 10.1016/j.molcel.2021.02.005.
Ferreira P, Höfer V, Kronshage N, Marko A, Reusswig KU, Tetik B, Köhler K, Tschernoster N, Altmüller J, Schulze N, Pfander B, Boos D*. (2021).
MTBP phosphroylation controls DNA replication origin firing.
Sci Rep. 11(1), 1-14 doi:10.1038/s41598-021-83287.
Capella M, Mandemaker IK, , Caballero LM, den Brave F, Pfander B, Ladurner AG, Jentsch S, Braun S* (2021).
Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase.
Nature Commun. 12, doi: 10.1038/s41467-021-25205-2.
2020
Bittmann J, Grigaitis R, Galanti L, Amarell S, Wilfling F, Matos J & Pfander B*. (2020).
An advanced cell cycle tag toolbox reveals principles underlying temporal control of structure-selective nucleases.
Elife. May 1;9:e52459, doi: 10.7554/eLife.52459.
Allegretti M, Zimmerli C, Rantos V, Wilfling F, Ronchi P, Fung KHH, Lee C, Hagen W, Turonova B, , Karius K, Bömmel M, Zhang X, Müller CW, Schwab Y, Mahamid J, Pfander B*, Kosinski J*, Beck M* (2020).
In cell architecture of the nuclear pore and snapshots of its turnover.
Nature, doi: 10.1038/s41586-020-2670-5. Epub 2020 Sep 2.
Lee CW, Wilfling F, Ronchi P, Allegretti M, Mosalaganti S, Jentsch S, Beck M* & Pfander B*. (2020).
Selective autophagy degrades nuclear pore complexes.
Nat Cell Biol. Feb;22(2):159-166, doi: 10.1038/s41556-019-0459-2. Epub 2020 Feb 6.
Capella M, Caballero LM, Pfander B, Braun S*, Jentsch S. (2020).
ESCRT recruitment by the S. cerevisiae inner nuclear membrane protein Heh1 is regulated by Hub1-mediated alternative splicing.
J Cell Sci, 133 (24), doi: 10.1242/jcs.250688.
Bantele SC & Pfander B* (2020).
Quantitative mechanisms of DNA damage sensing and signaling.
Curr Genet. doi: 10.1007/s00294-019-01007-4.
2019
Bantele SCS, Lisby M & Pfander B* (2019).
Quantitative sensing of ssDNA accumulation by DNA damage checkpoint mediators.
Nature Commun. 10., doi: 10.1038/s41467-019-08889-5.
Bantele SC & Pfander B* (2019).
Nucleosome remodeling by Fun30/SMARCAD1 in the DNA damage response.
Front Mol Biosci. doi: 10.3389/fmolb.2019.00078.
Reusswig KU & Pfander B* (2019).
Control of DNA replication initiation – mechanisms to ensure smooth transitions.
Genes. 10(2), doi: 10.3390/genes10020099.
Heckmann I, Kern MJ, Pfander B*, Jentsch S (2019).
A SUMO-dependent pathway controls elongating Rpb1 upon UV-induced damage.
Scientific Reports. 9(1), 1-10.
Höpfler M, Kern MJ, Straub T, Prytuliak R, Habermann BH, Pfander B*, Jentsch S (2019).
Specificity in the STUbL-pathway exemplified by recruitment of Slx5/Slx8 to ubiquitin hotspots on chromatin.
EMBO J., 10.15252/embj.2018100368.
2018
Paasch F, den Brave F, Psakhye I, Pfander B*, Jentsch S (2018).
Failed mitochondrial import and impaired proteostasis trigger SUMOylation of mitochondrial proteins.
JBiol Chem. 293 (2); 599-609, doi: 10.1074/jbc.M117.817833.
Galanti L & Pfander B* (2018).
Right time, right place-DNA damage and DNA replication checkpoints collectively safeguard S phase.
EMBO J. 37(21), pii: e100681, doi: 10.15252/embj.2018100681.
2017
di Cicco G, Bantele SCS, Reusswig KU & Pfander B*. (2017).
A cell cycle-independent mode of the Rad9-Dpb11 interaction is induced by DNA damage.
Sci Rep., doi: 10.1038/s41598-017-11937-z.
Princz LN, Wild P, Bittmann J, Aguado FJ, Blanco MG, Matos J & Pfander B*. (2017).
Dbf4-dependent kinase and the Rtt107 scaffold promote Mus81-Mms4 resolvase activation during mitosis.
EMBO J., doi: 10.15252/embj.201694831.
Bantele SCS, Ferreira P, Gritenaite D, Boos D & Pfander B*. (2017).
Targeting of the Fun30 nucleosome remodeller by the Dpb11 scaffold facilitates cell cycle-regulated DNA end resection.
Elife., pii: e21687. doi: 10.7554/eLife.21687.
Karaduman R#*, Chanarat S#*, Pfander B*, Jentsch S (2017).
Error-Prone Splicing Controlled by the Ubiquitin Relative Hub1.
Mol Cell. 67(3); 423-432, doi: 10.1016/j.molcel.2017.06.021.
Lademann, C.A., Renkawitz, J., Pfander, B.* & Jentsch, S. (2017).
The INO80 Complex Removes H2A.Z to Promote Presynaptic Filament Formation during Homologous Recombination.
Cell Reports. 19(7):1294-1303, doi: 10.1016/j.celrep.2017.04.051.
2016
Reusswig KU, Zimmermann F, Galanti L & Pfander B* (2016).
Robust Replication Control Is Generated by Temporal Gaps between Licensing and Firing Phases and Depends on Degradation of Firing Factor Sld2.
Cell Rep. 17(2):556-569, doi: 10.1016/j.celrep.2016.09.013.
Reusswig KU, Boos D & Pfander B* (2016).
Roles of Sld2, Sld3, and Dpb11 in Replication Initiation.
In: The initiation of DNA replication in eukaryotes. pp 297-318. Springer, doi: 10.1007/978-3-319-24696-3.
Koehler K, Ferreira P, Pfander B & Boos, D* (2016).
Regulation of the Initiation of DNA Replication upon DNA Damage in Eukaryotes.
In: The initiation of DNA replication in eukaryotes. pp 443-460. Springer, doi: 10.1007/978-3-319-24696-3.
2015
Lee SH, Princz LN, Klügel MF, Habermann B, Pfander B & Biertümpfel C* (2015).
Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage.
Elife. pii:e12256, doi: 10.7554/eLife.12256.
2014
Princz LN, Gritenaite D & Pfander B* (2014).
The Slx4-Dpb11 scaffold complex: coordinating the response to replication fork stalling in S-phase and the subsequent mitosis.
Cell Cycle. 14(4):488-494, doi: 10.4161/15384101.2014.989126.
Gritenaite D, Princz LN, Szakal B, Bantele SCS, Wendeler L, Schilbach S, Habermann BH, Matos J, Lisby M, Branzei D, Pfander B* (2014).
A cell cycle-regulated Slx4-Dpb11 signaling complex controls the resolution of DNA repair intermediates linked to stalled replication.
Genes Dev. 28(14):1604-1619, doi: 10.1101/gad.240515.114.
2011
Pfander B & Diffley, JFX* (2011).
Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment.
EMBO J. 30: 4897-4907.
2010
Parnas O, Zipin-Roitman A, Pfander B, Liefshitz B, Mazor Y, Ben-Aroya S, Jentsch S & Kupiec M* (2010).
Elg1, an alternative subunit of the RF-C clamp loader, preferentially interacts with SUMOylated PCNA.
EMBO J. 29:2611-2622.
2007
Moldovan GL, Pfander B & Jentsch S* (2007).
PCNA, the maestro of the replication fork.
Cell. 129, 665-679.
2006
Sacher M, Pfander B, Hoege C & Jentsch S* (2006).
Control of Rad52 recombination activity by double-strand break-induced SUMO modification.
Nature Cell Biology. 8, 1284-1290.
Moldovan GL, Pfander B & Jentsch S* (2006).
PCNA controls establishment of sister chromatid cohesion during S-phase.
Molecular Cell. 23, 723-732.
Döring M, Loos A, Schrader N, Pfander B & Bauerfeind R* (2006).
Nerve growth factor-induced phosphorylation of amphiphysin-1 by casein kinase 2 regulates clathrin-amphiphysin interactions.
Journal of Neurochemistry. 98, 2013-2023.
2005
Pfander B, Moldovan GL, Sacher M, Hoege C & Jentsch S* (2005).
SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase.
Nature. 436, 428-433.
Sacher M#, Pfander B# & Jentsch S* (2005).
Identification of SUMO-protein conjugates.
Methods in Enzymology. 399, 392-404.
2002
Hoege C, Pfander B, Moldovan GL, Pyrowolakis G & Jentsch S* (2002).
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.
Nature. 419, 135-141.