Publications and Patents
2024
*: Corresponding Author, §: Equally Contributed
93. S. Banerjee, Z. V. Cakil, K. Gallant, J. van den Boom, S. Palei, H. Meyer, M. Gersch* and D. Summerer*
Light-Activatable Ubiquitin for Studying Linkage-Specific Ubiquitin Chain Formation Kinetics
Adv. Sci. 2024, in press.
92. M. A. Vibhute, C. Machatzke, K. Bigler, S. Kruempel, D. Summerer, H. Mutschler*
Intracellular Expression of a Fluorogenic DNA Aptamer Using Retron Eco2
eLife. 2024, doi.org/10.1002/anie.202318837.
91. B. Kosel, K. Bigler, B. C. Buchmuller, S. R. Acharyya, R. Linser*, and D. Summerer*
Evolved Readers of 5-Carboxylcytosine CpG Dyads Reveal a High Versatility of the Methyl-CpG-Binding Domain for Recognition of Noncanonical Epigenetic Marks
Angew. Chem. 2024, 63(17), e202318837doi.org/10.1002/anie.202318837.
90. T. C. Lin, L. Engelhard, B. Söldner, R. Linser, and D. Summerer*
Light-Activatable MBD-Readers of 5-Methylcytosine Reveal Domain-Dependent Chromatin Association Kinetics In Vivo
Adv. Sci. 2024, 2307930 11(11), e2307930. doi: 10.1002/advs.202307930.
2023
89. Himanshu Singh, Chandan K. Das, Benjamin C. Buchmuller, Simone Eppmann, Lars V. Schäfer*, Daniel Summerer*, Rasmus Linser*
Epigenetic CpG Duplex Marks Probed by an Evolved DNA Reader via a Well-Tempered Conformational Plasticity
Nucleic Acids Res. 2023, 51(12), 6495-506, doi: 10.1093/nar/gkad134.
88. Jung, Anne; Muñoz López, Álvaro; Buchmuller, Benjamin; Banerjee, Sudakshina; Summerer, Daniel
Imaging-based in situ Analysis of 5-Methylcytosine at Low Repetitive Single Gene Loci with Transcription-Activator-Like Effector Probes
ACS Chem. Biol., 2023, 18(2), 230-36, doi: 10.1021/acschembio.2c00857
2022
87. S. Palei§, J. Weisner§, M. Vogt, R. Gontla, B. Buchmuller, C. Ehrt, T. Grabe, S. Kleinbölting, M. Müller, G. H. Clever*, Daniel Rauh,* and Daniel Summerer*
A high-throughput effector screen identifies a novel small molecule scaffold for inhibition of ten-eleven translocation dioxygenase 2
RSC Med. Chem., 2022, 13, 1540-48. Corrigendum: RSC Medicinal Chemistry, 2024, 15, 753 - 754.
86. T. C. Lin, S. Palei and D. Summerer*
Optochemical Control of TET Dioxygenases Enables Kinetic Insights into the Domain-Dependent Interplay of TET1 and MBD1 while Ox-idizing and Reading 5-Methylcytosine
ACS Chem. Biol., 2022, 17(7), 1844-1852, 10.1021/acschembio.2c00245
85. Benjamin C. Buchmuller, Jessica Dröden, Himanshu Singh, Shubhendu Palei, Malte Drescher, Rasmus Linser* and Daniel Summerer*
Evolved DNA Duplex Readers for Strand-Asymmetrically Modified 5-Hydroxymethylcytosine/5-Methylcytosine CpG Dyads
J. Am. Chem. Soc., 2022, 144, 2987-93, doi: 10.1021/jacs.1c10678.
2021
84. J. Wolffgramm, B. Buchmuller, S. Palei, Á. Muñoz-López, J. Kanne, P. Janning, M. R. Schweiger* and D. Summerer*
Light-Activation of DNA-Methyltransferases
Angew. Chem., 2021, 60(24), 13507-12, doi: 10.1002/anie.202103945
83. J. Kanne§, M. Hussong§, J. Isensee, A. Muñoz-López, J. Wolffgramm, F. Heß, C. Grimm, S. Bessonov, L. Meder, J. Wang, H. C. Reinhardt, M. Odenthal, T. Hucho, R. Büttner, D. Summerer and M. R. Schweiger*
Pericentromeric satellite III transcripts induce etoposide resistance
Cell Death & Disease, 2021, 12(6), 530, doi: 10.1038/s41419-021-03810-9
82. B. Buchmuller, A. Jung, A. Munoz-Lopez and D. Summerer*
Programmable Tools for the Targeted Analysis of Epigenetic DNA Modifications
Curr. Opin. Chem. Biol., 2021, 63, 1-10, doi: 10.1016/j.cbpa.2021.01.002
81. B. Buchmuller, A. Munoz-Lopez, M. Giess and D. Summerer*
Design and application of DNA modification-specific transcription-activator-like effectors
Meth. Mol. Biol., 2021, 2198, 381-99, doi: 10.1007/978-1-0716-0876-0_29
80. A. Munoz-Lopez, A. Jung, B. Buchmuller, J. Wolffgramm, S. Maurer, A. Witte and D. Summerer*
Engineered TALE Repeats for Enhanced Imaging-based Analysis of Cellular 5-Methylcytosine
ChemBioChem, 2021, 22(4), 645-51, doi: 10.1002/cbic.202000563
2020
79. A. Witte, A. Munoz-Lopez, M. Metz, M. R. Schweiger, P. Janning and D. Summerer*
Encoded, Click-Reactive DNA-Binding Domains for Programmable Capture of Specific Chromatin Segments
Chem. Sci., 2020, 11, 46, 12506-11, doi: 10.1039/D0SC02707C
78. S. Palei, B. Buchmuller, J. Wolffgramm, A. Munoz-Lopez, S. Jung, P. Czodrowski, D. Summerer*
Light-Activatable TET-Dioxygenases Reveal Dynamics of 5-Methylcytosine Oxidation and Transcriptome Reorganization
J. Am. Chem. Soc., 2020, 142, 7289-94. doi.org/10.1021/jacs.0c01193
77. B. Buchmuller, B. Kosel, D. Summerer*
Complete Profiling of Methyl-CpG-Binding Domains for Combinations of Cytosine Modifications at CpG Dinucleotides Reveals Differential Read-out in Normal and Rett-Associated States
Sci. Rep., 2020, 10 (1), 4053, doi: 10.1038/s41598-020-61030-1
76. A. Munoz-Lopez, B. Buchmuller, J. Wolffgramm, A. Jung, M. Hussong, J. Kanne, M. R. Schweiger* and D. Summerer*
Designer Receptors for Nucleotide Resolution Analysis of Genomic 5-Methylcytosine by Cellular Imaging
Angew. Chem. Int. Ed., 2020, 59 (23), 8927-31. doi.org/10.1002/anie.202001935
75. B. Buchmuller, D. Summerer
Method for determining 5-methylcytosine configurations in DNA
Patent Application, 2020, 19 220 082.2, filed by the TU Dortmund.
74. P. Widder, J. Schuck, D. Summerer* and M. Drescher*
Combining site-directed spin labeling in vivo and in-cell EPR Distance Determination
Phys. Chem. Chem. Phys., 2020, 22, 4875-9, doi: 10.1039/c9cp05584c
2019
73. T. Braun, P. Widder, U. Osswald, L. Groß, L. Williams, M. J. Schmidt, I. Helmle, D. Summerer* and Malte Drescher*
Isoindoline-Based Nitroxides as Bioresistant Spin Labels for Protein Labeling via Cysteines and Alkyne bearing Noncanonical Amino Acids
ChemBioChem, 2019, doi: 10.1002/cbic.201900537.
72. M. Giess, A. Munoz-Lopez, B. Buchmuller, G. Kubik and D. Summerer*
Programmable Protein-DNA Crosslinking for the Direct Capture and Quantification of 5-Formylcytosine
J. Am. Chem. Soc., 2019, 141, 9453-7, doi: 10.1021/jacs.9b01432
71. P. Widder, F. Berner, D. Summerer* and M. Drescher*
Double Nitroxide Labeling by Copper-Catalyzed Azide-Alkyne Cycloadditions with Noncanonical Amino Acids for EPR Spectroscopy
ACS Chem. Biol., 2019,14(5), 839-44, doi: 10.1021/acschembio.8b01111
70. A. Kugele, T. Braun, P. Widder, L. Williams, M. J. Schmidt, D. Summerer*, M. Drescher*
Site-Directed spin labelling of proteins by Suzuki-Miyaura coupling via a genetically encoded aryliodide amino acid
Chem. Commun., 2019, 55(13), 1923-1926, doi: 10.1039/c8cc09325c
69. T. Braun, M. Drescher* and D. Summerer*
Expanding the genetic code for site-directed spin-labeling
Int. J. Mol. Sci. ., 2019, 9, 20(2), E373, doi: 10.3390/ijms20020373
(Special Issue on “Expanding and Reprogramming the Genetic Code”, edited by K. Sakamoto).
2018
68. S. Maurer, B. Buchmuller, C. Ehrt, J. Jasper, O. Koch and D. Summerer*
Overcoming conservation in TALE-DNA interactions: A minimal repeat scaffold enables selective rerognition of an oxidized 5-methylcytosine
Chem. Sci., 2018, 9, 7247-52, doi: 10.1039/c8sc01958d
67. M. Gieß, A. Witte, J. Jasper, O. Koch and D. Summerer*
Complete, programmable decoding of oxidized 5-methylcytosine nucleobases in DNA by chemoselective blockage of universal transcription-activator-like effector repeats
J. Am. Chem. Soc., 2018, 140, 5904-8, doi: 10.1021/jacs.8b02909
66. H. Neumann*, P. Neumann-Staubitz, A. Witte and D. Summerer*
Epigenetic chromatin modification by amber suppression technology
Curr. Opin. Chem. Biol., 2018, 45, 1-9, doi: 10.1016/j.cbpa.2018.01.017
65. M. J. Schmidt, and D. Summerer*
Directed evolution of orthogonal pyrrolysyl-tRNA synthetases in Escherichia coli for the genetic encoding of noncanonical amino acids
Meth. Mol. Biol., 2018, 1728, 97-111, doi: 10.1007/978-1-4939-7574-7_5
64. A. Munoz-Lopez and D. Summerer*
Recognition of oxidized 5-methylcytosine derivatives in DNA by natural and engineered protein scaffolds
Chem. Rec., 2018, 18(1), 105-16, doi: 10.1002/tcr.201700088
63. P. Rathi, S. Maurer and D. Summerer*
Selective recognition of N4-methylcytosine in DNA by engineered transcription-activator-like effectors
Philos. Trans. R. Soc. Lond. B Biol. Sci., 2018, 373, 1748, doi: 10.1098/rstb.2017.0078
(Special Issue on “‘Frontiers in Epigenetic Chemical Biology”).
2017
62. P. Rathi, A. Witte and D. Summerer*
Engineering DNA backbone interactions results in TALE scaffolds with enhanced 5-methylcytosine selectivity
Sci. Rep., 2017, 7, 15067, doi: 10.1038/s41598-017-15361-1
61. S. Flade, J. Jasper, M. Giess, M. Juhasz, A. Dankers, G. Kubik, O. Koch*, E. Weinhold* and D. Summerer*
The N6-position of adenine is a blind spot for TAL-effectors that enables effective binding of methylated and fluorophore-labeled DNA
ACS Chem. Biol., 2017, 12 (7), 1719-25, doi: 10.1021/acschembio.7b00324
2016
60. S. Maurer, M. Giess, O. Koch and D. Summerer*
Interrogating key positions of size-reduced TALE-repeats reveals a programmable sensor of 5-carboxylcytosine
ACS Chem. Biol., 2016,11 (12), 3294-9, doi: 10.1021/acschembio.6b00627
59. Y. J. Lee, M. J. Schmidt, J. M. Tharp, A. Weber, J. Gao, M. L. Waters, D. Summerer* and W. R. Liu*
Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader
Chem. Commun., 2016, 52 (85), 12606-9, doi: 10.1039/c6cc05959g
58. P. Rathi, S. Maurer, G. Kubik and D. Summerer*
Isolation of human genomic DNA sequences with expanded nucleobase selectivity
J. Am. Chem. Soc., 2016,138, 9910-18, doi: 10.1021/jacs.6b04807
57. P. Roser, M. J. Schmidt, M. Drescher* and D. Summerer*
Site-directed spin labeling of proteins for distance measurements in vitro and in cells
Org. Biomol. Chem., 2016,14, 5468-76, doi: 10.1039/c6ob00473c
56.G. Kubik and D. Summerer*
TALEored epigenetics: A DNA-binding scaffold for programmable epigenome editing and analysis
ChemBioChem., 2016,17, 975-80, doi: 10.1002/cbic.201600072
55. D. Summerer*, M. Giess, S. Maurer, G. Kubik
Transcription activator-like effector (TALE)-based decoding of cytosine nucleobases by selective modification response
Patent application., 2016, filed by the University of Konstanz.
2015
54. M. J. Schmidt, A. Fedoseev, D. Bücker, J. Borbas, C. Peter, M. Drescher* and D. Summerer*
EPR Distance measurements in native proteins with genetically encoded spin labels
ACS Chem. Biol., 2015, 18, 2764-71, doi: 10.1021/acschembio.5b00512
53. D. Summerer*
N6-Methyladenine: A potential epigenetic mark in eukaryotic genomes
Angew. Chem. Int. Ed., 2015, 54, 10714-6, doi: 10.1002/anie.201504594
52. M. J. Schmidt, A. Fedoseev, D. Summerer* and M. Drescher*
Genetically encoded spin labels for in vitro and in-cell EPR studies of native proteins
Methods Enzymol., 2015, 563, 483-502, doi: 10.1016/bs.mie.2015.05.023
51. G. Kubik and D. Summerer*
Deciphering epigenetic cytosine modifications by direct molecular recognition
ACS Chem. Biol., 2015, 10, 1580-9, doi: 10.1021/acschembio.5b00158
50. G. Kubik, S. Batke and D. Summerer*
Programmable sensors of 5-hydroxymethylcytosine
J. Am. Chem. Soc., 2015, 137, 2-5, doi: 10.1021/ja506022t
49. G. Kubik and D. Summerer*
Achieving single nucleotide resolution of 5-methylcytosine detection with TALEs
ChemBioChem., 2015, 16, 228-31, doi: 10.1002/cbic.201402408
48. B. Klauser, C. Rehm, D. Summerer and J. S. Hartig
Engineering of ribozyme-based aminoglycoside switches of gene expression by in vivo genetic selection in Saccharomycesc erevisiae
Methods Enzymol., 2015, 550, 301-20, doi: 10.1016/bs.mie.2014.10.037
47. D. Summerer, M. J. Schmidt, M. Drescher
Genetically encoded spin label
Patent application, 2015, PCT/EP2015/050568, filed by the University of Konstanz
2014
46. M. Pott, M. J. Schmidt and D. Summerer*
Evolved sequence contexts for highly efficient amber suppression with noncanonical amino acids
ACS Chem. Biol., 2014, 9, 2815-22, doi: 10.1021/cb5006273
45. G. Kubik, M. J. Schmidt, J. E. Penner and D. Summerer*
Programmable and highly resolved in vitro detection of genomic 5-methylcytosine by TALEs
Angew. Chem. Int. Ed., 2014, 53, 6002-6, doi: 10.1002/anie.201400436
44. M. J. Schmidt, A. Weber, M. Pott, W. Welte and D. Summerer*
Structural basis of furan-amino acid recognition by a polyspecific aminoacyl-tRNA-synthetase and its genetic encoding in human cells
ChemBioChem, 2014, 15, 1755-60, doi: 10.1002/cbic.201402006
43. M. J. Schmidt and D. Summerer*
Genetic code expansion as a tool to study regulatory processes of transcription
Front. Chem., 2014, 2 (7), 1-11, doi: 10.3389/fchem.2014.00007
42. M. J. Schmidt, J. Borbas, M. Drescher* and D. Summerer*
A genetically encoded spin label for electron paramagnetic resonance distance measurements
J. Am. Chem. Soc., 2014, 136, 1238-41, doi: 10.1021/ja411535q
Three times highlighted by Faculty of 1000 (including rating: “exceptional”)
41. D. Summerer, M. J. Schmidt
Intercalating amino acids
Patent application, 2014, PCT/EP2014/065601, filed by the University of Konstanz
40. D. Summerer, G. Kubik, M. J. Schmidt
Direct, programmable detection of epigenetic cytosine modifications using TAL effectors
Patent application, 2014, PCT/EP2014/001753, filed by the University of Konstanz
2013
39. M. J. Schmidt, D. Summerer*
Red-light-controlled protein-RNA crosslinking with a genetically encoded furan
Angew. Chem. Int. Ed., 2013, 52, 4690-93, doi: 10.1002/anie.201300754
2012
38. M. J. Schmidt, D. Summerer*
A need for speed: genetic encoding of rapid cycloaddition chemistries for protein labelling in living cells
ChemBioChem, 2012, 13, 1553-57, doi: 10.1002/cbic.201200321
PI, Biotech Industry (Epigenetics, Genomics/Transcriptomics)
37. D. Summerer*
High-throughput DNA sequencing beyond the four-letter code: epigenetic modifications revealed by single molecule bypass kinetics
ChemBioChem, 2010, 11, 2499-501, doi: 10.1002/cbic.201000569
36. D. Summerer*, D. Hevroni, A. Jain, O. Scheck, J. Parker, A. Caruso, P.F. Stähler, C.F. Stähler and M. Beier
A flexible and fully integrated system for amplification, detection and genotyping of genomic DNA targets based on microfluidic oligonucleotide arrays
N. Biotechnology, 2010, 27, 149-55, doi: 10.1016/j.nbt.2010.03.005
35. M. Beier, P. F. Stähler, C.F. Stähler, J. Leonhard, D. Summerer, S. Bau
Process for the investigation of nucleic acid populations
Patent application, 2010, DE102008061772A1, filed by febit holding gmbh
34. D. Summerer*, N. Schracke, H. Wu, Y. Cheng, S. Bau, C.F. Stähler, P.F. Stähler and M. Beier
Targeted high throughput sequencing of a cancer-related exome subset by specific sequence capture with a fully automated microarray platform
Genomics, 2010, 95, 241-6, doi: 10.1016/j.ygeno.2010.01.006
33. C.F. Stähler, P.F. Stähler, M. Beier, D. Summerer
Integrated amplification, processing and analysis of biomolecules in a microfluidic reaction medium
Patent application, 2010, WO2010043418, filed by febit holding gmbh
32. D. Summerer*
Enabling technologies of genomic-scale sequence enrichment for high throughput sequencing
Genomics, 2009, 94, 363-8, doi: 10.1016/j.ygeno.2009.08.012
31. N. Schracke, M. Kränzle, P. F. Stähler, D. Summerer and M. Beier
Specific sequence selection and next generation resequencing of 68 E. coli genes using HybSelect
N. Biotechnology, 2009, 26, 229-33, doi: 10.1016/j.nbt.2009.08.013
30. D. Summerer*, H. Wu, B. Haase, Y. Cheng, N. Schracke, C.F. Stähler, M.S. Chee, P.F. Stähler and M. Beier
Microarray-based multicycle-enrichment of genomic subsets for targeted next-generation sequencing
Genome Res., 2009, 19, 1616-21, doi: 10.1101/gr.091942.109
Described methodology was highlighted in the Faculty of 1000s magazine The Scientist: “The ten most exciting tools to hit the life sciences in 2009″
29. S. Bau, N. Schracke, M. Kränzle, H. Wu, J. D. Hoheisel, P. F. Stähler, M. Beier and D. Summerer*
Targeted next-generation-sequencing by specific capture of multiple genomic loci using microfluidic low-volume DNA arrays
Anal. Bioanal. Chem., 2009, 393, 171-5, doi: 10.1007/s00216-008-2460-7
28. C.F. Stähler, P.F. Stähler, M. Beier, S. Bau, D. Summerer
Flexible extraction method for the production of sequence-specific molecule libraries
Patent application, 2009, WO2009065620, filed by febit holding gmbh
27. C.F. Stähler, P.F. Stähler, M. Beier, D. Summerer, M. Matzas, S. Vorwerk
Improved molecular biological processing system
Patent application, 2008, WO2008080629, filed by febit holding gmbh
Postdoc, The Scripps Research Institute (Chemical Biology, Genetic Code Expansion)
26. D.H. Jones, S.E. Cellitti, X. Hao, Q. Zhang, M. Jahnz, D. Summerer, P.G. Schultz, T. Uno, B.H. Geierstanger
Site-specific labeling of proteins with NMR-active unnatural amino acids
J. Biomol. NMR, 2010, 46, 89-100, doi: 10.1007/s10858-009-9365-4
25. E.M. Tippmann, W. Liu, D. Summerer, Mack A.V. and P.G. Schultz
A genetically encoded diazirine photocrosslinker in Escherichia Coli
ChemBioChem, 2007, 8, 2210-4, doi: 10.1002/cbic.200700460
24. E.A. Lemke§, D. Summerer§, B.H. Geierstanger, S.M. Brittain and P.G. Schultz
Control of protein phosphorylation with a genetically encoded photocaged amino acid
Nature Chem. Biol., 2007, 3, 769-72, doi: 10.1038/nchembio.2007.44
Faculty of 1000 evaluation: factor 10, exceptional.
Highlighted in Analytical Chemistry, January 1, 2008, “Photocaged amino acids enable scientists to study phosphorylation in vivo“
Highlighted by Arnaud, CH, Chemical & Engineering News, 2007, October 31, “Modified Serine Controls Protein Phosphorylation”
Highlighted by Richards, NGJ, The HFSP Journal, 2008, 2(2), 57-60 “Shining a light on posttranslational modification”
23. D. Summerer, S. Chen, N. Wu, A. Deiters, J.W. Chin and P.G. Schultz
A genetically encoded, fluorescent amino acid
Proc. Nat. Acad. Sci. USA, 2006, 103, 9785-9, doi: 10.1073/pnas.0603965103
Faculty of 1000 evaluation: factor 8, must read
22. Peter G. Schultz, Alexander Deiters, Lital Alfonta, Jonathan R. Chittuluru, Dan Groff, Daniel Summerer, Meng-Lin Tsao, Jiangyun Wang, Ning Wu, Jianming Xie and Huaqiang Zeng
Orthogonal translation components for the in vivo incorporation of unnatural amino acids
Patent application, 2006, WO2006110182, filed by the Scripps Research Institute, licensed to Novartis.
21. M.L. Tsao, D. Summerer, P.G. Schultz
The genetic incorporation of a distance probe into proteins in Escherichia coli
J. Am. Chem. Soc., 2006, 128, 4572-3, doi: 10.1021/ja058262u
20. A. Deiters, T.A. Cropp, D. Summerer, M. Mukherji, P.G. Schultz
Site-specific PEGylation of proteins containing unnatural amino acids
Bioorg. Med. Chem. Lett. 2004, 14, 5743-5, doi: 10.1016/j.bmcl.2004.09.059
PhD, University of Bonn (Chemical Biology, DNA Replication)
19. D. Summerer*
DNA polymerase profiling
Meth. Mol. Biol., 2008, 225, doi: 10.1007/978-1-60327-040-3_16
18. D. Summerer, N.Z. Rudinger, I. Detmer, A. Marx
Enhanced fidelity of mismatch extension by DNA polymerase through directed combinatorial enzyme design
Angew. Chem. Int. Ed., 2005, 44, 4712-5, doi: 10.1002/anie.200500047
17. D. Summerer, A. Marx
4´-C-Ethynylthymidine acts as a chain terminator during DNA-synthesis catalyzed by HIV-1 reverse transcriptase
Bioorg. Med. Chem. Lett., 2005, 15, 869-71, doi: 10.1016/j.bmcl.2004.12.072
16. A. Marx, Nikolas Z. Rudinger, D. Summerer
Mutated DNA Polymerases with increased mispairing discrimination
Patent application, 2005, WO2005074350, filed by the University of Bonn, licensed to Qiagen.
15. A. Marx, D. Summerer
Bigger DNA: New genetic helix with expanded size
Angew. Chem. Int. Ed., 2004, 43, 1625-6, doi: 10.1002/anie.200301737
14. M. Strerath, J. Gaster, D. Summerer, A. Marx
Increased single-nucleotide discrimination of PCR by primer probes bearing hydrophobic 4’-C-modifications
ChemBioChem, 2004, 5, 333-9, doi: 10.1002/cbic.200300757
13. A. Marx, D. Summerer, M. Strerath
Selectivity of DNA replication
Highlights in Bioorganic Chemistry: Methods and Application, Editors: C. Schmuck, H. Wennemers, WILEY-VCH, 2004, 299-308
12. A. Marx, I. Detmer, J. Gaster, D. Summerer
Probing DNA polymerase function with synthetic tools
Synthesis, 2004, 1, 1-14, doi: 10.1055/s-2003-44363
11. D. Summerer and A. Marx
4′-C-Modified nucleotides as chemical tools for investigation and modulation of DNA polymerase function
Synlett, 2004, 2, 217-24
10. A. Marx, M. Strerath, D. Summerer, A. Pingoud, B. Tews, M. Hahn, P. Friedhoff, J. Wilhelm
Improved method for allele-specific PCR
Patent application, 2003, WO2003072814, filed by Roche Diagnostics gmbh / Hoffmann La Roche
9. B. Tews, J. Wilhelm, D. Summerer, M. Strerath, A. Marx, P. Friedhoff, A. Pingoud, M. Hahn
Application of the C4´-alkylated deoxyribose primer system (CAPS) in allele specific real-time PCR for increased selectivity in discrimination of single nucleotide sequence variants
Biol. Chem. 2003, 384, 1533-41, doi: 10.1515/BC.2003.170
8. I. Detmer, D. Summerer, A. Marx
Substrates for investigation of DNA polymerase function: Synthesis and properties of 4’-C-alkylated oligonucleotides
Eur. J. Org. Chem. 2003, 10, 1837-46, doi: 10.1002/ejoc.200200641
7. I. Detmer, D. Summerer, A. Marx
DNA minor groove hydration probed with 4’-alkylated thymidines
Chem. Commun. 2002, 20, 2314-5, doi: 10.1039/b207582m
6. D. Summerer, A. Marx
A molecular beacon for quantitative monitoring of the DNA polymerase reaction in real-time
Angew. Chem. Int. Ed. 2002, 41, 3620-2, doi: 10.1002/1521-3773(20021004)41:19<3620::AID-ANIE3620>3.0.CO;2-C
5. M. Strerath, D. Summerer, A. Marx
Varied DNA polymerase-substrate interactions in the nucleotide binding pocket
ChemBioChem 2002, 3, 578-80, doi: 10.1002/1439-7633(20020603)3:6<578::AID-CBIC578>3.0.CO;2-W
4. D. Summerer, A. Marx
Differential minor groove interactions between DNA polymerase and sugar backbone of primer and template strands
J. Am. Chem. Soc. 2002, 124, 910-1, doi: 10.1021/ja017244j
3. A. Marx, D. Summerer
Molecular insights into error-prone DNA replication and error-free lesion bypass
ChemBioChem 2002, 3, 405-8, doi: 10.1002/1439-7633(20020503)3:5<405::AID-CBIC405>3.0.CO;2-4
Highlighted by Faculty of 1000
2. D. Summerer, A. Marx
DNA-templated synthesis: More versatile than expected
Angew. Chem. Int. Ed. 2002, 41, 89-90, doi: 10.1002/1521-3773(20020104)41:1<89::AID-ANIE89>3.0.CO;2-G
1. D. Summerer, A. Marx
DNA polymerase selectivity: sugar interactions monitored with high fidelity nucleotides
Angew. Chem. Int. Ed. 2001, 40, 3693-5, doi: 10.1002/1521-3773(20011001)40:19<3693::aid-anie3693>3.0.co;2-o