Jump label

Service navigation

Main navigation

You are here:

Main content

Publications

2018

  1. Koch P, Brunschweiger A, Namasivayam V, Ullrich S, Maruca A, Lazzaretto B, Küppers P, Hinz S, Hockemeyer J, Wiese M, Alcaro S, Kiec-Kononowiz5 K, Müller C E "Probing substituents in the 1- and 3-position: Tetrahydropyrazino-annelated water-soluble xanthine derivatives as multi-target drugs with potent adenosine receptor antagonistic activity" Front. Chem. 2018 [link] (in press)

2017

  1. Menzi M, Wild B, Pradère U, Malinowska AL, Brunschweiger A, Lightfoot HL, Hall J "Towards improved oligonucleotide therapeutics through faster target binding kinetics" Chemistry - A European Journal 2017 accepted [link]

  2. Klika Škopić M, Willems S, Wagner B, Schieven J, Krause N, Brunschweiger A "Exploration of a Au(I)-mediated three-component reaction for the synthesis of DNA-tagged highly substituted spiroheterocycles" Org. Biomol. Chem. 2017 [link]

  3. Klika Škopić M, Salamon H, Bugain O, Jung K, Gohla A, Doetsch L J, dos Santos D, Bhat A, Wagner B, Brunschweiger A "Acid- and Au(I)-mediated synthesis of hexathymidine-DNA-heterocycle chimeras, an efficient entry to DNA-encoded libraries inspired by drug structures" Chemical Science 2017 [link]

2016

  1. Salamon H, Škopić M K, Jung K, Bugain O, Brunschweiger A "Chemical Biology Probes from Advanced DNA-encoded Libraries" ACS Chem. Biol. 2017 [link]
  2. Brunschweiger A, Koch P, Schlenk M, Rafehi M, Radjainia H, Küppers P, Hinz S, Pineda F, Wiese M, Hockemeyer J, Heer J, Denonne F, Müller C E "8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors" Bioorganic & Medicinal Chemistry 2016 [link]

  3. Klika Škopić M, Bugain O, Jung K, Onstein S, Brandherm S, Kalliokoski T and Brunschweiger A " Design and synthesis of DNA-encoded libraries based on a benzodiazepine and a pyrazolopyrimidine scaffold" MedChemComm 2016 [link]

2015

  1. Brunschweiger A, Gebert L F R, Lucic M, Pradère U, Jahns H, Berk C, Hunziker J, Hall J "Site-specific conjugation of drug-like fragments to an antimiR scaffold as a strategy to target miRNAs inside RISC" Chem. Commun. 2015 Oct 2015 [link]

  2. Imig J*, Brunschweiger A*, Brümmer A, Guennewig B, Mittal N, Kishore S, Tsikrika P, Gerber AP, Zavolan M, Hall J "miR-CLIP capture of a miRNA targetome uncovers a lincRNA H19-miR-106a interaction" Nat Chem Biol. 2015 Dec 22 [link] (* joint first)

2014

  1. Brunschweiger A "Report from the Third Annual Symposium of the RIKEN-Max Planck Joint Research Center for Systems Chemical Biology." ACS Chem Biol 2014 Aug 15, 9(8):1649-52 [link]

  2. Brunschweiger A, Koch P, Schlenk M, Pineda F, Küppers P, Hinz S, Köse M, Ullrich S, Hockemeyer J, Wiese M, Heer J, Müller CE "8-Benzyltetrahydropyrazino[2,1-f]purinediones: water-soluble tricyclic xanthine derivatives as multitarget drugs for neurodegenerative diseases." ChemMedChem Aug, 9(8):1704-24 [link]

2013

  1. Koch P, Akkari R, Brunschweiger A, Borrmann T, Schlenk M, Küppers P, Köse M, Radjainia H, Hockemeyer J, Drabczyńska A, Kieć-Kononowicz K, Müller CE "1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases." Bioorg Med Chem. 2013 Sep 25

  2. Pradère U, Brunschweiger A, Gebert LF, Lucic M, Roos M, Hall J "Chemical Synthesis of Mono- and Bis-Labeled Pre-MicroRNAs." Angew Chem Int Ed Engl. 2013 Sep 23

  3. Rebhan MA, Brunschweiger A, Hall J "Measurement by SPR of Very Low Dissociation Rates: Oxidation-Mediated Loss of Biotin-Streptavidin Affinity." Chembiochem. 2013 Sep 18

2012

  1. Ripphausen P, Freundlieb M, Brunschweiger A, Zimmermann H, Müller CE, Bajorath J "Virtual screening identifies novel sulfonamide inhibitors of ecto-5'-nucleotidase." J Med Chem. 2012 Jul 26, 55(14): 6576-81

  2. Brunschweiger A, Hall J "A decade of the human genome sequence – how does the medicinal chemist benefit?" ChemMedChem. 2012 7: 194-203

  3. Loughlin FE, Gebert LFR, Towbin H, Brunschweiger A, Hall J, Allain FHT "Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28" Nat. Struct. Mol. Biol. 2012 19: 84-89

  4. Ripphausen P, Freundlieb M, Brunschweiger A, Zimmermann H, Müller CE, Bajorath J "Identification of first-in-class inhibitors of ecto-5´-nucleotidaseJ." Med. Chem. 2012 55: 6576-81

2011

  1. Loughlin FE, Gebert LF, Towbin H, Brunschweiger A, Hall J, Allain FH "Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28." Nat Struct Mol Biol. 2011 Dec 11, 19(1):84-9

2008

  1. A. Brunschweiger, J. Iqbal, F. Umbach, A. B. Scheiff, M. N. Munkonda, J. Sévigny, A. F. Knowles, C. E. Müller, "Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5’-carboxamide." J. Med. Chem. 2008, 51, 4518 - 4528.

2007

  1. C. E. Müller, A. Brunschweiger, J. Iqbal, "Preparation of nucleotide mimetics as ectonucleotidase inhibitors." Eur. Pat. Appl. 2007 EP 1860113 A1 20071108

2006

  1. A. Brunschweiger and C. E. Müller, "Medizinische Chemie der Diuretika." Pharmazie in Unserer Zeit 2006, 35, 310-320.

  2. A. Brunschweiger, J. Iqbal, A. Scheiff, M. N. Munkonda, J. Sévigny, A. F. Knowles, C. E. Müller, "Synthesis and structure-activity relationships of 5'-substituted uridine and adenosine derivatives as ectonucleotidase inhibitors." Abstract in: Purinergic Signalling 2006, 2, 170.

  3. A. Brunschweiger and C. E. Müller, "P2 Receptors activated by uracil nucleotides – an update." Curr. Med. Chem. 2006 12, 325-348.

2001

  1. A. Brunschweiger and D. Heber, "Two Approaches to α,α-bis-Mannich Salts of N-monosubstituted Amides." Tet. Lett. 2001, 42, 2653-2656.


    

 

Back