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Publications

Complete list of publications



Gersch M, Wagstaff JL, Toms AV, Graves B, Freund SMV, Komander D,

“Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity”

Mol Cell, 2019, 74(3), 436–451. doi

 

Stahl M, Korotkov VS, Balogh D, Kick LM, Gersch M, Pahl A, Kielkowski P, Richter K, Schneider S, Sieber SA,

“Selective Activation of Human Caseinolytic Protease P (ClpP)”

Angew Chem Int Ed, 2018, 57(44), 14602-14607. doi

 

Turnbull AP, Ioannidis S, Krajewski WW, Pinto-Fernandez A, Heride C, Martin ACL, Tonkin LM, Townsend EC, Buker SM, Lancia DR, Caravella JA, Toms AV, Charlton TM, Lahdenranta J, Wilker E, Follows BC, Evans NJ, Stead L, Alli C, Zarayskiy VV, Talbot AC, Buckmelter AJ, Wang M, McKinnon CL, Saab F, McGouran JF, Century H, Gersch M, Pittman MS, Marshall CG, Raynham TM, Simcox M, Stewart LMD, McLoughlin SB, Escobedo JA, Bair KW, Dinsmore CJ, Hammonds TR, Kim S, Urbé S, Clague MJ, Kessler BM, Komander D,

“Molecular basis of USP7 inhibition by selective small-molecule inhibitors”

Nature, 2017, 550, 481–486. doi

 

Gersch M, Gladkova C, Schubert A, Michel M, Maslen S, Komander D,

“Mechanism and regulation of the Lys6-selective deubiquitinase USP30”

Nat Struct Mol Biol, 2017, 24(11), 920–930. (Also highlighted in Nat Chem Biol). doi

 

Hundshammer C, Düwel S, Köcher S, Gersch M, Feuerecker B, Scheurer C, Haase A, Glaser SJ, Schwaiger M, Schilling F,

“Deuteration of hyperpolarized 13C-labeled zymonic acid enables sensitivity-enhanced dynamic MRI of pH”

ChemPhysChem, 2017, 18, 2422–2425. doi

 

Düwel S, Hundshammer C, Gersch M, Feuerecker B, Steiger K, Buck A, Walch A, Haase A, Glaser SJ, Schwaiger M, Schilling F,

“Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid”

Nat Commun, 2017, 8, 15126. doi

 

Balogh D, Dahmen M, Stahl M, Poreba M, Gersch M, Drag M, Sieber SA,

“Insights into ClpXP proteolysis: heterooligomerization and partial deactivation enhance chaperone affinity and substrate turnover in Listeria monocytogenes”

Chem Sci, 2017, 8, 1592–1600. doi

 

Mevissen TE, Kulathu Y, Mulder MP, Geurink PP, Maslen SL, Gersch M, Elliott PR, Burke JE, van Tol BD, Akutsu M, El Oualid F, Kawasaki M, Freund SM, Ovaa H, Komander D,

“Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne”

Nature, 2016, 538(7625), 402–405. doi

 

Gersch M, Stahl M, Poreba M, Dahmen M, Dziedzic A, Drag M, Sieber SA

 “Barrel-shaped ClpP proteases display attenuated cleavage specificities”

ACS Chem Biol, 2016, 19(11), 389–399. doi

 

Gersch M, Hackl M, Dubiella C, Dobrinevski A, Groll M, Sieber SA,

“Intact protein mass spectrometry of 20S proteasomes reveals complex integrity, phosphorylation stoichiometry and inhibitor specificity”

Chem Biol, 2015, 22(3), 404–411. doi

 

Gersch M, Famulla K, Dahmen M, Goebl C, Malik I, Richter K, Korotkov VS, Sass P, Ruebsamen-Schaeff H, Madl T, Broetz-Oesterhelt H, Sieber SA,

“AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control”

Nat Commun, 2015, 19(6), 6320. doi

 

Wauer T, Swatek KN, Wagstaff JL, Gladkova C, Pruneda JN, Michel MA, Gersch M, Johnson CM, Freund SM, Komander D,

“Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis”

EMBO J, 2015, 34(3), 307–325. doi

 

Gersch M, Sieber SA,

“Modulation of ClpP Protease Activity: from Antibiotics to Antivirulence”

In: Concepts and Case Studies in Chemical Biology, 2014, Wiley-VCH, Weinheim.

 

Dubiella C, Cui H, Gersch M, Brouwer A, Sieber SA, Krüger A, Liskamp RM, Groll M,

“Selective immunoproteasome inhibition by ligand-induced active site crosslinking”

Angew Chem Int Ed, 2014, 53(44), 11969–11973. doi

 

Gersch M, Kolb R, Alte F, Groll M, Sieber SA,

"Disruption of oligomerization and dehydroalanine formation as mechanisms for ClpP protease inhibition"

J Am Chem Soc, 2014, 136(4),1360–1366. doi

 

Schilling F, Glaser SJ, Düwel S, Gersch M,

“pH-biosensors based on compounds produced from pyruvic acid for magnetic resonance imaging and spectroscopy and their uses”

European patent EP3058375, filed: 15.10.2014, granted: 26.12.2018.

 

Zeiler E, List A, Alte F, Gersch M, Wachtel R, Poreba M, Drag M, Groll M, Sieber SA,

"Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad“

Proc Natl Acad Sci USA, 2013, 110(28), 11302–11307. doi

 

Gersch M, Gut F, Korotkov V, Lehmann J, Böttcher T, Rusch M, Hedberg C, Waldmann H, Klebe G, Sieber SA,

"The Mechanism of ClpP Inhibition",

Angew Chem Int Ed, 2013, 52(10), 3009–3014. doi

 

Gersch M, Kreuzer J, Sieber SA,

"Electrophilic natural products and their biological targets",

Nat Prod Rep, 2012, 29, 659–682. doi

 

Gersch M, List A, Groll M, Sieber SA,

"Insights into the structural network responsible for oligomerization and activity of the bacterial virulence regulator caseinolytic protease P (ClpP)"

J Biol Chem, 2012, 287(12), 9484–9494. doi

 

Shen A, Lupardus PJ, Gersch M, Puri AW, Albrow VE, Garcia KC, Bogyo M,

"Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins"

Nat Struct Mol Biol, 2011, 18(3), 364–371. doi

 

Gersch M, Sieber SA,

"Disarming Clostridium difficile"

Chem Biol, 2010, 17, 1165–1166. doi



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Funding & Projects

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Emmy-Noether-Programm

 

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INTERNATIONAL MAX PLANCK RESEARCH SCHOOL