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38. A. L. Satz, A. Brunschweiger, M. E. Flanagan, A. Gloger, N. J. V. Hansen, L. Kuai, V. B. K. Kunig, X. Lu, D. Madsen, L. A. Marcaurelle, C. Mulrooney, G. O’Donovan, S. Sakata, J. Scheuermann,
DNA-encoded chemical libraries.
Nat. Rev. Methods Primers, 2022, accepted


37. J. H. Hunter, M Potowski, H. A. Stanway-Gordon, A. Madin, G. Pairaudeau, A. Brunschweiger,* M. J. Waring,*
Functional group tolerance of a micellar on-DNA Suzuki-Miyaura cross-coupling reaction for DNA-encoded library de­sign.
J. Org. Chem. 2021, 86, 17930–17935.

36. M. Potowski, R. Lüttig, A. Vakalopoulos, A. Brunschweiger,*
Copper(I/II)-promoted diverse imidazo[1,2-α]pyridine synthesis on solid-phase bound DNA oligonucleotides for encoded library de­sign.
Org. Lett. 2021, 23, 5480–5484.

35. M. Potowski, V. B. K. Kunig, L. Eberlein, A. Vakalopoulos, S. M. Kast,* A. Brunschweiger,*
Chemically stabilized DNA barcodes for DNA-encoded chem­is­try.
Angew. Chem. Int. Ed. 2021, 60, 19744-19749

34. Mateja Klika Škopić, Christian Gramse, Rosario Oliva, Sabrina Pospich, Laura Neukirch, Magiliny Manisegaran, Stefan Raunser, Roland Winter, Ralf Weberskirch, An­dre­as Brunschweiger,
Towards DNA-Encoded Micellar Chem­is­try: DNA-Micelle Association and Environment Sensitivity of Catalysis.
Chem. Eur. J. 2021, 27, 10048-10057. Highlighted as back cover.

33. V. B. K. Kunig, M. Potowski, M. Klika Škopić, A. Brunschweiger,
"Scanning protein surface with DNA-encoded libraries."
Chemmedchem 202116, 1048-1062. Invited review, VIP article.


32. V. B. K. Kunig, M. Potowski, M. Akbarzadeh, M. Klika Škopić, D. dos Santos Smith, L. Arendt, I. Dormuth, H. Adihou, B. Andlovic, H. Karatas, S. Shaabani, T. Zarganes-Tzitzikas, C. G. Neochoritis, R. Zhang, M. Groves, S. M. Guéret, C. Ottmann, J. Rahnenführer, R. Fried, A. Dömling, A. Brunschweiger,
"TEAD-YAP interaction inhibitors and MDM2 binders from DNA-encoded indole-focused Ugi-peptidomimetics."
Angew. Chem. Int. Ed. 2020, 59, 20338-20342.
The TEAD-YAP-inhibitors (Angew. Chem. Int. Ed. 2020) have been highlighted in ChemistryViews.

31. K. Götte, S. Chines, A. Brunschweiger
"Reaction Development for DNA-Encoded Library Technology: From Evolution to Revolution?"
Tet. Lett., 2020, 61, 151889. Invited Digest Article by Tetrahedron Letters.

30. M. Potowski, R. Esken, A. Brunschweiger
"Translation of the copper/bipyridine-promoted Petasis reaction to solid phase-coupled DNA for encoded library synthesis"
Bioorg. Med. Chem. 2020, 28, 115441.

29. D. Kögel, B. Linder, A. Brunschweiger, S. Chines, C. Behl
"At the Crossroads of Apoptosis and Autophagy: Multiple Roles of the Co-Chaperone BAG3 in Stress and Therapy Resistance of Cancer.
Cells. 2020, 9, 574.

28. J. Bobers, M. Klika Škopic, R. Dinter, P. Sakthithasan, L. Neukirch, C. Gramse, R. Weberskirch, A. Brunschweiger,* N. Kockmann,*
"Design of an Automated Reagent-Dispensing System for Reaction Screening and Validation with DNA-tagged Substrates"
ACS Comb. Sci., 2020,  22, 101-108.


27. M. Potowski, F. Losch, E. Wünnemann, J. K. Dahmen, S. Chines, A. Brunschweiger
"Screening of metal ions and organocatalysts on solid support-coupled DNA oligonucleotides guides de­sign of DNA-encoded reactions"
Chem. Sci. 2019, 10, 10481-10492.

26. V. B. K. Kunig, C. Ehrt, A. Dömling, A. Brunschweiger
"Isocyanide multicomponent reactions on solid phase-coupled DNA oligonucleotides for encoded library synthesis"
Org. Lett. 2019, 21, 7238-7243.

25. M. Klika Škopic, K. Götte, C. Gramse, M. Dieter, S. Pospich, S. Raunser, R. Weberskirch, A. Brunschweiger,
"Micellar Brønsted Acid Mediated Synthesis of DNA-Tagged Heterocycles"
J. Am. Chem. Soc. 2019, 141, 26, 10546-10555.

24. M. Potowski, V. B. K. Kunig, F. Losch, A. Brunschweiger,
"Synthesis of DNA-coupled isoquinolones and pyrrolidines by solid phase ytterbium- and silver-mediated imine chem­is­try"
Med. Chem. Commun., 2019, 10, 1082-1093. Highlighted as front cover


23. P. Koch, A. Brunschweiger, V. Namasivayam, S. Ullrich, A. Maruca, B. Lazzaretto, P. Küppers, S. Hinz, J. Hockemeyer, M. Wiese, S. Alcaro, K. Kiec-Kononowiz, C. E. Müller,
"Probing substituents in the 1- and 3-position: Tetrahydropyrazino-annelated water-soluble xanthine derivatives as multi-target drugs with potent adenosine receptor antagonistic activity."
Front. Chem. 2018.

22. V. B. K. Kunig, M. Potowski, A. Gohla, A. Brunschweiger,*
"DNA-encoded libraries – an efficient small molecule dis­cov­ery technology for the biomedical sciences."
Biol. Chem., 2018, 399, 691-710.


21. M. Klika Škopic, S. Willems, B. Wagner, J. Schieven, N. Krause, A. Brunschweiger,*
"Exploration of a Au(I)-mediated three-component reaction for the synthesis of DNA-tagged highly substituted spiroheterocycles."
Org. Biomol. Chem., 2017, 15, 8648-8654.

20. M. Menzi, B. Wild, U. Pradère, A. L. Malinowska, A. Brunschweiger, H. L. Lightfoot, J. Hall,
"Towards improved oligonucleotide therapeutics through faster target binding kinetics."
Chem. Eur. J., 2017, 23, 14221-14230.

19. M. Klika Škopic, H. Salamon, O. Bugain, K. Jung, A. Gohla, L. J. Doetsch, D. dos Santos, A. Bhat, B. Wagner, A. Brunschweiger,*
"Acid- and Au(I)-mediated synthesis of hexathymidine-DNA-heterocycle chimeras, an efficient entry to DNA-encoded libraries inspired by drug structures."
Chem. Sci. 2017, 8, 3356-3361. Highlighted as inside front cover


18. M. Klika Škopic, O. Bugain, K. Jung, S. Onstein, S. Brandherm, T. Kalliokoski, A. Brunschweiger,*
"Design and synthesis of DNA-encoded libraries based on a benzodiazepine and a pyrazolopyrimidine scaffold."
Med. Chem. Commun. 2016, 7, 1957-1965.

17. H. Salamon, M. Klika S?kopic´, K. Jung, O. Bugain, A. Brunschweiger,*
"Chemical biology probes from advanced DNA-encoded libraries."
ACS Chem. Biol. 2016, 19, 296-307.

16. A. Brunschweiger,* L. F. Gebert*, M. Lucic, U. Pradère, H. Jahns, J. Hunziker, J. Hall,
"Site-specific conjugation of drug-like fragments to anti-miRNA oligonucleotides demonstrates pros and cons of targeting miRNAs in RISC."
Chem. Commun. 2016, 52, 156-159. *joint first authors

15. A. Brunschweiger, P. Koch, M. Schlenk, R. M, Radjainia, P. Küppers, S. Hinz, F. Pineda, M. Wiese, J. Hockemeyer, J. Heer, F. Denonne, C. E. Müller,
"8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors."
Bioorg. Med. Chem. 2016, 24, 5462-5480.


14. J. Imig,*  A. Brunschweiger,* A. Brümmer, B. Guennewig, N. Mittal, S. Kishore, P. Tsikrika, A. P. Gerber, M. Zavolan, J. Hall,
"MiR-CLIP capture of a miRNA targetome uncovers a lincRNA H19-miR-106a interaction."
Nat. Chem. Biol. 2015, 11, 107-114. * joint first authors


13. A. Brunschweiger
"Report from the Third Annual Symposium of the RIKEN-Max Planck Joint Research Center for Sys­tems Chemical Biology."
ACS Chem. Biol. 2014, 9, 1649-1652.

12. A. Brunschweiger, P. Koch, M. Schlenk, F. Pineda, P. Küppers, S. Hinz, M. Köse, S. Ullrich, J. Hockemeyer, M. Wiese, J. Heer, C. E. Müller,
"8-Benzyltetrahydropyrazino[2,1-f]purinediones: water-soluble tricyclic xanthine derivatives as multitarget drugs for neurodegenerative diseases."
ChemMedChem 2014, 9, 1704-1724.


11. P. Koch, R. Akkari, A. Brunschweiger, T. Borrmann, M. Schlenk, P. Küppers, M. Köse, H. Radjainia, J. Hockemeyer, A. Drabczynska, K. Kiec-Kononowicz, C. E. Müller,
"1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases."
Bioorg. Med. Chem. 2013, 21, 7435-7452.

10. U. Pradère, A. Brunschweiger, L. F. Gebert, M. Lucic, M. Roos M, J. Hall,
"Chemical Synthesis of Mono- and Bis-Labeled Pre-MicroRNAs."
Angew. Chem. Int. Ed. Engl. 2013, 52, 12028-12032.

9. M. A. Rebhan, A. Brunschweiger, J. Hall,
"Measurement by SPR of Very Low Dissociation Rates: Oxidation-Mediated Loss of Biotin-Streptavidin Affinity."
Chembiochem 2013, 14, 2091-2094.


8. A. Brunschweiger, J. Hall,
"A decade of the human genome sequence – how does the medicinal chemist ben­efit?"
ChemMedChem. 2012, 7, 194-203.

7. F. E. Loughlin, L. F. Gebert, H. Towbin, A. Brunschweiger, J. Hall, H. H.-T. Allain,
"Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28"
Nat. Struct. Mol. Biol. 2012, 19, 84-89.

6. P. Ripphausen, M. Freundlieb, A. Brunschweiger, H. Zimmermann, C. E. Müller, J. Bajorath,
"Identification of first-in-class inhibitors of ecto-5´-nucleotidaseJ."
Med. Chem. 2012, 55, 6576-81.


5. A. Brunschweiger, J. Iqbal, F. Umbach, A. B. Scheiff, M. N. Munkonda, J. Sévigny, A. F. Knowles, C. E. Müller,
"Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5’-carboxamide."
J. Med. Chem. 2008, 51, 4518 - 4528.


4. A. Brunschweiger and C. E. Müller,
"Medizinische Chemie der Diuretika."
Pharmazie in Unserer Zeit 2006, 35, 310-320.

3. A. Brunschweiger, J. Iqbal, A. Scheiff, M. N. Munkonda, J. Sévigny, A. F. Knowles, C. E. Müller,
"Synthesis and structure-activity relationships of 5'-substituted uridine and adenosine derivatives as ectonucleotidase inhibitors."
Abstract in: Purinergic Signalling 2006, 2, 170.

2. A. Brunschweiger and C. E. Müller,
"P2 Receptors activated by uracil nucleotides – an update."
Curr. Med. Chem. 2006, 12, 325-348.


1. A. Brunschweiger and D. Heber,
"Two Approaches to α,α-bis-Mannich Salts of N-monosubstituted Amides."
Tet. Lett. 2001, 42, 2653-2656.

Location & approach

The campus of TU Dort­mund Uni­ver­sity is located close to interstate junction Dort­mund West, where the Sauerlandlinie A 45 (Frankfurt-Dort­mund) crosses the Ruhrschnellweg B 1 / A 40. The best interstate exit to take from A 45 is "Dort­mund-Eichlinghofen" (closer to Cam­pus Süd), and from B 1 / A 40 "Dort­mund-Dorstfeld" (closer to Cam­pus Nord). Signs for the uni­ver­si­ty are located at both exits. Also, there is a new exit before you pass over the B 1-bridge leading into Dort­mund.

To get from Cam­pus Nord to Cam­pus Süd by car, there is the connection via Vo­gel­pothsweg/Baroper Straße. We recommend you leave your car on one of the parking lots at Cam­pus Nord and use the H-Bahn (suspended monorail system), which conveniently connects the two campuses.

TU Dort­mund Uni­ver­sity has its own train station ("Dort­mund Uni­ver­si­tät"). From there, suburban trains (S-Bahn) leave for Dort­mund main station ("Dort­mund Hauptbahnhof") and Düsseldorf main station via the "Düsseldorf Airport Train Station" (take S-Bahn number 1, which leaves every 20 or 30 minutes). The uni­ver­si­ty is easily reached from Bo­chum, Essen, Mülheim an der Ruhr and Duis­burg.

You can also take the bus or subway train from Dort­mund city to the uni­ver­si­ty: From Dort­mund main station, you can take any train bound for the Station "Stadtgarten", usually lines U41, U45, U 47 and U49. At "Stadtgarten" you switch trains and get on line U42 towards "Hombruch". Look out for the Station "An der Palmweide". From the bus stop just across the road, busses bound for TU Dort­mund Uni­ver­sity leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dort­mund main station to the stop "Dort­mund Kampstraße". From there, take U43 or U44 to the stop "Dort­mund Wittener Straße". Switch to bus line 447 and get off at "Dort­mund Uni­ver­si­tät S".

The H-Bahn is one of the hallmarks of TU Dort­mund Uni­ver­sity. There are two stations on Cam­pus Nord. One ("Dort­mund Uni­ver­si­tät S") is directly located at the suburban train stop, which connects the uni­ver­si­ty directly with the city of Dort­mund and the rest of the Ruhr Area. Also from this station, there are connections to the "Technologiepark" and (via Cam­pus Süd) Eichlinghofen. The other station is located at the dining hall at Cam­pus Nord and offers a direct connection to Cam­pus Süd every five minutes.

The AirportExpress is a fast and convenient means of transport from Dort­mund Airport (DTM) to Dort­mund Central Station, taking you there in little more than 20 minutes. From Dort­mund Central Station, you can continue to the uni­ver­si­ty campus by interurban railway (S-Bahn). A larger range of in­ter­na­tio­nal flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the uni­ver­si­ty station.

The facilities of TU Dort­mund Uni­ver­sity are spread over two campuses, the larger Cam­pus North and the smaller Cam­pus South. Additionally, some areas of the uni­ver­si­ty are located in the adjacent "Technologiepark".

Site Map of TU Dort­mund Uni­ver­sity (Second Page in English).