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Publications

2020

32. V. B. K. Kunig, M. Potowski, M. Akbarzadeh, M. Klika Škopić, D. dos Santos Smith, L. Arendt, I. Dormuth, H. Adihou, B. Andlovic, H. Karatas, S. Shaabani, T. Zarganes-Tzitzikas, C. G. Neochoritis, R. Zhang, M. Groves, S. M. Guéret, C. Ottmann, J. Rahnenführer, R. Fried, A. Dömling, A. Brunschweiger,
"TEAD-YAP interaction inhibitors and MDM2 binders from DNA-encoded indole-focused Ugi-peptidomimetics."
Angew. Chem. Int. Ed. 2020, accepted.
The TEAD-YAP-inhibitors (Angew. Chem. Int. Ed. 2020) have been highlighted in ChemistryViews.

31. K. Götte, S. Chines, A. Brunschweiger
"Reaction Development for DNA-Encoded Library Technology: From Evolution to Revolution?"
Tet. Lett., 2020, 61, 151889. Invited Digest Article by Tetrahedron Letters.

30. M. Potowski, R. Esken, A. Brunschweiger
"Translation of the copper/bipyridine-promoted Petasis reaction to solid phase-coupled DNA for encoded library synthesis"
Bioorg. Med. Chem. 2020, 28, 115441.

29. D. Kögel, B. Linder, A. Brunschweiger, S. Chines, C. Behl
"At the Crossroads of Apoptosis and Autophagy: Multiple Roles of the Co-Chaperone BAG3 in Stress and Therapy Resistance of Cancer.
Cells. 2020, 9, 574.

28. J. Bobers, M. Klika Škopic, R. Dinter, P. Sakthithasan, L. Neukirch, C. Gramse, R. Weberskirch, A. Brunschweiger,* N. Kockmann,*
"Design of an Automated Reagent-Dispensing System for Reaction Screening and Validation with DNA-tagged Substrates"
ACS Comb. Sci., 2020,  22, 101-108.

2019

27. M. Potowski, F. Losch, E. Wünnemann, J. K. Dahmen, S. Chines, A. Brunschweiger
"Screening of metal ions and organocatalysts on solid support-coupled DNA oligonucleotides guides design of DNA-encoded reactions"
Chem. Sci. 2019, accepted.

26. V. Kunig, C. Ehrt, A. Dömling, A. Brunschweiger
"Isocyanide multicomponent reactions on solid phase-coupled DNA oligonucleotides for encoded library synthesis"
Org. Lett. 2019, 21, 7238-7243.

25. M. Klika Škopic, K. Götte, C. Gramse, M. Dieter, S. Pospich, S. Raunser, R. Weberskirch, A. Brunschweiger,
"Micellar Brønsted Acid Mediated Synthesis of DNA-Tagged Heterocycles"
J. Am. Chem. Soc. 2019, 141, 26, 10546-10555.

24. M. Potowski, V. B. K. Kunig, F. Losch, A. Brunschweiger,
"Synthesis of DNA-coupled isoquinolones and pyrrolidines by solid phase ytterbium- and silver-mediated imine chemistry"
Med. Chem. Commun., 2019, 10, 1082-1093. Highlighted as front cover

2018

23. P. Koch, A. Brunschweiger, V. Namasivayam, S. Ullrich, A. Maruca, B. Lazzaretto, P. Küppers, S. Hinz, J. Hockemeyer, M. Wiese, S. Alcaro, K. Kiec-Kononowiz, C. E. Müller,
"Probing substituents in the 1- and 3-position: Tetrahydropyrazino-annelated water-soluble xanthine derivatives as multi-target drugs with potent adenosine receptor antagonistic activity."
Front. Chem. 2018.

22. V. Kunig, M. Potowski, A. Gohla, A. Brunschweiger,*
"DNA-encoded libraries – an efficient small molecule discovery technology for the biomedical sciences."
Biol. Chem., 2018, 399, 691-710.

2017

21. M. Klika Škopic, S. Willems, B. Wagner, J. Schieven, N. Krause, A. Brunschweiger,*
"Exploration of a Au(I)-mediated three-component reaction for the synthesis of DNA-tagged highly substituted spiroheterocycles."
Org. Biomol. Chem., 2017, 15, 8648-8654.

20. M. Menzi, B. Wild, U. Pradère, A. L. Malinowska, A. Brunschweiger, H. L. Lightfoot, J. Hall,
"Towards improved oligonucleotide therapeutics through faster target binding kinetics."
Chem. Eur. J., 2017, 23, 14221-14230.

19. M. Klika Škopic, H. Salamon, O. Bugain, K. Jung, A. Gohla, L. J. Doetsch, D. dos Santos, A. Bhat, B. Wagner, A. Brunschweiger,*
"Acid- and Au(I)-mediated synthesis of hexathymidine-DNA-heterocycle chimeras, an efficient entry to DNA-encoded libraries inspired by drug structures."
Chem. Sci. 2017, 8, 3356-3361. Highlighted as inside front cover

2016

18. M. Klika Škopic, O. Bugain, K. Jung, S. Onstein, S. Brandherm, T. Kalliokoski, A. Brunschweiger,*
"Design and synthesis of DNA-encoded libraries based on a benzodiazepine and a pyrazolopyrimidine scaffold."
Med. Chem. Commun. 2016, 7, 1957-1965.

17. H. Salamon, M. Klika S?kopic´, K. Jung, O. Bugain, A. Brunschweiger,*
"Chemical biology probes from advanced DNA-encoded libraries."
ACS Chem. Biol. 2016, 19, 296-307.

16. A. Brunschweiger,* L. F. Gebert*, M. Lucic, U. Pradère, H. Jahns, J. Hunziker, J. Hall,
"Site-specific conjugation of drug-like fragments to anti-miRNA oligonucleotides demonstrates pros and cons of targeting miRNAs in RISC."
Chem. Commun. 2016, 52, 156-159. *joint first authors

15. A. Brunschweiger, P. Koch, M. Schlenk, R. M, Radjainia, P. Küppers, S. Hinz, F. Pineda, M. Wiese, J. Hockemeyer, J. Heer, F. Denonne, C. E. Müller,
"8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors."
Bioorg. Med. Chem. 2016, 24, 5462-5480.

2015

14. J. Imig,*  A. Brunschweiger,* A. Brümmer, B. Guennewig, N. Mittal, S. Kishore, P. Tsikrika, A. P. Gerber, M. Zavolan, J. Hall,
"MiR-CLIP capture of a miRNA targetome uncovers a lincRNA H19-miR-106a interaction."
Nat. Chem. Biol. 2015, 11, 107-114. * joint first authors

2014

13. A. Brunschweiger
"Report from the Third Annual Symposium of the RIKEN-Max Planck Joint Research Center for Systems Chemical Biology."
ACS Chem. Biol. 2014, 9, 1649-1652.

12. A. Brunschweiger, P. Koch, M. Schlenk, F. Pineda, P. Küppers, S. Hinz, M. Köse, S. Ullrich, J. Hockemeyer, M. Wiese, J. Heer, C. E. Müller,
"8-Benzyltetrahydropyrazino[2,1-f]purinediones: water-soluble tricyclic xanthine derivatives as multitarget drugs for neurodegenerative diseases."
ChemMedChem 2014, 9, 1704-1724.

2013

11. P. Koch, R. Akkari, A. Brunschweiger, T. Borrmann, M. Schlenk, P. Küppers, M. Köse, H. Radjainia, J. Hockemeyer, A. Drabczynska, K. Kiec-Kononowicz, C. E. Müller,
"1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases."
Bioorg. Med. Chem. 2013, 21, 7435-7452.

10. U. Pradère, A. Brunschweiger, L. F. Gebert, M. Lucic, M. Roos M, J. Hall,
"Chemical Synthesis of Mono- and Bis-Labeled Pre-MicroRNAs."
Angew. Chem. Int. Ed. Engl. 2013, 52, 12028-12032.

9. M. A. Rebhan, A. Brunschweiger, J. Hall,
"Measurement by SPR of Very Low Dissociation Rates: Oxidation-Mediated Loss of Biotin-Streptavidin Affinity."
Chembiochem 2013, 14, 2091-2094.

2012

8. A. Brunschweiger, J. Hall,
"A decade of the human genome sequence – how does the medicinal chemist benefit?"
ChemMedChem. 2012, 7, 194-203.

7. F. E. Loughlin, L. F. Gebert, H. Towbin, A. Brunschweiger, J. Hall, H. H.-T. Allain,
"Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28"
Nat. Struct. Mol. Biol. 2012, 19, 84-89.

6. P. Ripphausen, M. Freundlieb, A. Brunschweiger, H. Zimmermann, C. E. Müller, J. Bajorath,
"Identification of first-in-class inhibitors of ecto-5´-nucleotidaseJ."
Med. Chem. 2012, 55, 6576-81.

2008

5. A. Brunschweiger, J. Iqbal, F. Umbach, A. B. Scheiff, M. N. Munkonda, J. Sévigny, A. F. Knowles, C. E. Müller,
"Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5’-carboxamide."
J. Med. Chem. 2008, 51, 4518 - 4528.

2006

4. A. Brunschweiger and C. E. Müller,
"Medizinische Chemie der Diuretika."
Pharmazie in Unserer Zeit 2006, 35, 310-320.

3. A. Brunschweiger, J. Iqbal, A. Scheiff, M. N. Munkonda, J. Sévigny, A. F. Knowles, C. E. Müller,
"Synthesis and structure-activity relationships of 5'-substituted uridine and adenosine derivatives as ectonucleotidase inhibitors."
Abstract in: Purinergic Signalling 2006, 2, 170.

2. A. Brunschweiger and C. E. Müller,
"P2 Receptors activated by uracil nucleotides – an update."
Curr. Med. Chem. 2006, 12, 325-348.

2001

1. A. Brunschweiger and D. Heber,
"Two Approaches to α,α-bis-Mannich Salts of N-monosubstituted Amides."
Tet. Lett. 2001, 42, 2653-2656.

Location & approach

The campus of TU Dort­mund University is located close to interstate junction Dort­mund West, where the Sauerlandlinie A 45 (Frankfurt-Dort­mund) crosses the Ruhrschnellweg B 1 / A 40. The best interstate exit to take from A 45 is "Dort­mund-Eichlinghofen" (closer to Campus Süd), and from B 1 / A 40 "Dort­mund-Dorstfeld" (closer to Campus Nord). Signs for the uni­ver­si­ty are located at both exits. Also, there is a new exit before you pass over the B 1-bridge leading into Dort­mund.

To get from Campus Nord to Campus Süd by car, there is the connection via Vogelpothsweg/Baroper Straße. We recommend you leave your car on one of the parking lots at Campus Nord and use the H-Bahn (suspended monorail system), which conveniently connects the two campuses.

TU Dort­mund University has its own train station ("Dort­mund Uni­ver­si­tät"). From there, suburban trains (S-Bahn) leave for Dort­mund main station ("Dort­mund Hauptbahnhof") and Düsseldorf main station via the "Düsseldorf Airport Train Station" (take S-Bahn number 1, which leaves every 20 or 30 minutes). The uni­ver­si­ty is easily reached from Bochum, Essen, Mülheim an der Ruhr and Duisburg.

You can also take the bus or subway train from Dort­mund city to the uni­ver­si­ty: From Dort­mund main station, you can take any train bound for the Station "Stadtgarten", usually lines U41, U45, U 47 and U49. At "Stadtgarten" you switch trains and get on line U42 towards "Hombruch". Look out for the Station "An der Palmweide". From the bus stop just across the road, busses bound for TU Dort­mund University leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dort­mund main station to the stop "Dort­mund Kampstraße". From there, take U43 or U44 to the stop "Dort­mund Wittener Straße". Switch to bus line 447 and get off at "Dort­mund Uni­ver­si­tät S".

The H-Bahn is one of the hallmarks of TU Dort­mund University. There are two stations on Campus Nord. One ("Dort­mund Uni­ver­si­tät S") is directly located at the suburban train stop, which connects the uni­ver­si­ty directly with the city of Dort­mund and the rest of the Ruhr Area. Also from this station, there are connections to the "Technologiepark" and (via Campus Süd) Eichlinghofen. The other station is located at the dining hall at Campus Nord and offers a direct connection to Campus Süd every five minutes.

The AirportExpress is a fast and convenient means of transport from Dort­mund Airport (DTM) to Dort­mund Central Station, taking you there in little more than 20 minutes. From Dort­mund Central Station, you can continue to the uni­ver­si­ty campus by interurban railway (S-Bahn). A larger range of in­ter­na­tio­nal flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the uni­ver­si­ty station.

The facilities of TU Dort­mund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the uni­ver­si­ty are located in the adjacent "Technologiepark".

Site Map of TU Dort­mund University (Second Page in English).