33. V. B. K. Kunig, M. Potowski, M. Klika Škopić, A. Brunschweiger,
"Scanning protein surface with DNA-encoded libraries."
Chemmedchem 2020, accepted.
32. V. B. K. Kunig, M. Potowski, M. Akbarzadeh, M. Klika Škopić, D. dos Santos Smith, L. Arendt, I. Dormuth, H. Adihou, B. Andlovic, H. Karatas, S. Shaabani, T. Zarganes-Tzitzikas, C. G. Neochoritis, R. Zhang, M. Groves, S. M. Guéret, C. Ottmann, J. Rahnenführer, R. Fried, A. Dömling, A. Brunschweiger,
"TEAD-YAP interaction inhibitors and MDM2 binders from DNA-encoded indole-focused Ugi-peptidomimetics."
Angew. Chem. Int. Ed. 2020, 59, 20338-20342.
The TEAD-YAP-inhibitors (Angew. Chem. Int. Ed. 2020) have been highlighted in ChemistryViews.
31. K. Götte, S. Chines, A. Brunschweiger
"Reaction Development for DNA-Encoded Library Technology: From Evolution to Revolution?"
Tet. Lett., 2020, 61, 151889. Invited Digest Article by Tetrahedron Letters.
30. M. Potowski, R. Esken, A. Brunschweiger
"Translation of the copper/bipyridine-promoted Petasis reaction to solid phase-coupled DNA for encoded library synthesis"
Bioorg. Med. Chem. 2020, 28, 115441.
29. D. Kögel, B. Linder, A. Brunschweiger, S. Chines, C. Behl
"At the Crossroads of Apoptosis and Autophagy: Multiple Roles of the Co-Chaperone BAG3 in Stress and Therapy Resistance of Cancer.
Cells. 2020, 9, 574.
28. J. Bobers, M. Klika Škopic, R. Dinter, P. Sakthithasan, L. Neukirch, C. Gramse, R. Weberskirch, A. Brunschweiger,* N. Kockmann,*
"Design of an Automated Reagent-Dispensing System for Reaction Screening and Validation with DNA-tagged Substrates"
ACS Comb. Sci., 2020, 22, 101-108.
27. M. Potowski, F. Losch, E. Wünnemann, J. K. Dahmen, S. Chines, A. Brunschweiger
"Screening of metal ions and organocatalysts on solid support-coupled DNA oligonucleotides guides design of DNA-encoded reactions"
Chem. Sci. 2019, accepted.
26. V. B. K. Kunig, C. Ehrt, A. Dömling, A. Brunschweiger
"Isocyanide multicomponent reactions on solid phase-coupled DNA oligonucleotides for encoded library synthesis"
Org. Lett. 2019, 21, 7238-7243.
25. M. Klika Škopic, K. Götte, C. Gramse, M. Dieter, S. Pospich, S. Raunser, R. Weberskirch, A. Brunschweiger,
"Micellar Brønsted Acid Mediated Synthesis of DNA-Tagged Heterocycles"
J. Am. Chem. Soc. 2019, 141, 26, 10546-10555.
24. M. Potowski, V. B. K. Kunig, F. Losch, A. Brunschweiger,
"Synthesis of DNA-coupled isoquinolones and pyrrolidines by solid phase ytterbium- and silver-mediated imine chemistry"
Med. Chem. Commun., 2019, 10, 1082-1093. Highlighted as front cover
23. P. Koch, A. Brunschweiger, V. Namasivayam, S. Ullrich, A. Maruca, B. Lazzaretto, P. Küppers, S. Hinz, J. Hockemeyer, M. Wiese, S. Alcaro, K. Kiec-Kononowiz, C. E. Müller,
"Probing substituents in the 1- and 3-position: Tetrahydropyrazino-annelated water-soluble xanthine derivatives as multi-target drugs with potent adenosine receptor antagonistic activity."
Front. Chem. 2018.
22. V. B. K. Kunig, M. Potowski, A. Gohla, A. Brunschweiger,*
"DNA-encoded libraries – an efficient small molecule discovery technology for the biomedical sciences."
Biol. Chem., 2018, 399, 691-710.
21. M. Klika Škopic, S. Willems, B. Wagner, J. Schieven, N. Krause, A. Brunschweiger,*
"Exploration of a Au(I)-mediated three-component reaction for the synthesis of DNA-tagged highly substituted spiroheterocycles."
Org. Biomol. Chem., 2017, 15, 8648-8654.
20. M. Menzi, B. Wild, U. Pradère, A. L. Malinowska, A. Brunschweiger, H. L. Lightfoot, J. Hall,
"Towards improved oligonucleotide therapeutics through faster target binding kinetics."
Chem. Eur. J., 2017, 23, 14221-14230.
19. M. Klika Škopic, H. Salamon, O. Bugain, K. Jung, A. Gohla, L. J. Doetsch, D. dos Santos, A. Bhat, B. Wagner, A. Brunschweiger,*
"Acid- and Au(I)-mediated synthesis of hexathymidine-DNA-heterocycle chimeras, an efficient entry to DNA-encoded libraries inspired by drug structures."
Chem. Sci. 2017, 8, 3356-3361. Highlighted as inside front cover
18. M. Klika Škopic, O. Bugain, K. Jung, S. Onstein, S. Brandherm, T. Kalliokoski, A. Brunschweiger,*
"Design and synthesis of DNA-encoded libraries based on a benzodiazepine and a pyrazolopyrimidine scaffold."
Med. Chem. Commun. 2016, 7, 1957-1965.
17. H. Salamon, M. Klika S?kopic´, K. Jung, O. Bugain, A. Brunschweiger,*
"Chemical biology probes from advanced DNA-encoded libraries."
ACS Chem. Biol. 2016, 19, 296-307.
16. A. Brunschweiger,* L. F. Gebert*, M. Lucic, U. Pradère, H. Jahns, J. Hunziker, J. Hall,
"Site-specific conjugation of drug-like fragments to anti-miRNA oligonucleotides demonstrates pros and cons of targeting miRNAs in RISC."
Chem. Commun. 2016, 52, 156-159. *joint first authors
15. A. Brunschweiger, P. Koch, M. Schlenk, R. M, Radjainia, P. Küppers, S. Hinz, F. Pineda, M. Wiese, J. Hockemeyer, J. Heer, F. Denonne, C. E. Müller,
"8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors."
Bioorg. Med. Chem. 2016, 24, 5462-5480.
14. J. Imig,* A. Brunschweiger,* A. Brümmer, B. Guennewig, N. Mittal, S. Kishore, P. Tsikrika, A. P. Gerber, M. Zavolan, J. Hall,
"MiR-CLIP capture of a miRNA targetome uncovers a lincRNA H19-miR-106a interaction."
Nat. Chem. Biol. 2015, 11, 107-114. * joint first authors
13. A. Brunschweiger
"Report from the Third Annual Symposium of the RIKEN-Max Planck Joint Research Center for Systems Chemical Biology."
ACS Chem. Biol. 2014, 9, 1649-1652.
12. A. Brunschweiger, P. Koch, M. Schlenk, F. Pineda, P. Küppers, S. Hinz, M. Köse, S. Ullrich, J. Hockemeyer, M. Wiese, J. Heer, C. E. Müller,
"8-Benzyltetrahydropyrazino[2,1-f]purinediones: water-soluble tricyclic xanthine derivatives as multitarget drugs for neurodegenerative diseases."
ChemMedChem 2014, 9, 1704-1724.
11. P. Koch, R. Akkari, A. Brunschweiger, T. Borrmann, M. Schlenk, P. Küppers, M. Köse, H. Radjainia, J. Hockemeyer, A. Drabczynska, K. Kiec-Kononowicz, C. E. Müller,
"1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases."
Bioorg. Med. Chem. 2013, 21, 7435-7452.
10. U. Pradère, A. Brunschweiger, L. F. Gebert, M. Lucic, M. Roos M, J. Hall,
"Chemical Synthesis of Mono- and Bis-Labeled Pre-MicroRNAs."
Angew. Chem. Int. Ed. Engl. 2013, 52, 12028-12032.
9. M. A. Rebhan, A. Brunschweiger, J. Hall,
"Measurement by SPR of Very Low Dissociation Rates: Oxidation-Mediated Loss of Biotin-Streptavidin Affinity."
Chembiochem 2013, 14, 2091-2094.
8. A. Brunschweiger, J. Hall,
"A decade of the human genome sequence – how does the medicinal chemist benefit?"
ChemMedChem. 2012, 7, 194-203.
7. F. E. Loughlin, L. F. Gebert, H. Towbin, A. Brunschweiger, J. Hall, H. H.-T. Allain,
"Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28"
Nat. Struct. Mol. Biol. 2012, 19, 84-89.
6. P. Ripphausen, M. Freundlieb, A. Brunschweiger, H. Zimmermann, C. E. Müller, J. Bajorath,
"Identification of first-in-class inhibitors of ecto-5´-nucleotidaseJ."
Med. Chem. 2012, 55, 6576-81.
5. A. Brunschweiger, J. Iqbal, F. Umbach, A. B. Scheiff, M. N. Munkonda, J. Sévigny, A. F. Knowles, C. E. Müller,
"Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5’-carboxamide."
J. Med. Chem. 2008, 51, 4518 - 4528.
4. A. Brunschweiger and C. E. Müller,
"Medizinische Chemie der Diuretika."
Pharmazie in Unserer Zeit 2006, 35, 310-320.
3. A. Brunschweiger, J. Iqbal, A. Scheiff, M. N. Munkonda, J. Sévigny, A. F. Knowles, C. E. Müller,
"Synthesis and structure-activity relationships of 5'-substituted uridine and adenosine derivatives as ectonucleotidase inhibitors."
Abstract in: Purinergic Signalling 2006, 2, 170.
2. A. Brunschweiger and C. E. Müller,
"P2 Receptors activated by uracil nucleotides – an update."
Curr. Med. Chem. 2006, 12, 325-348.
1. A. Brunschweiger and D. Heber,
"Two Approaches to α,α-bis-Mannich Salts of N-monosubstituted Amides."
Tet. Lett. 2001, 42, 2653-2656.
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Location & approach
The campus of TU Dortmund University is located close to interstate junction Dortmund West, where the Sauerlandlinie A 45 (Frankfurt-Dortmund) crosses the Ruhrschnellweg B 1 / A 40. The best interstate exit to take from A 45 is "Dortmund-Eichlinghofen" (closer to Campus Süd), and from B 1 / A 40 "Dortmund-Dorstfeld" (closer to Campus Nord). Signs for the university are located at both exits. Also, there is a new exit before you pass over the B 1-bridge leading into Dortmund.
To get from Campus Nord to Campus Süd by car, there is the connection via Vogelpothsweg/Baroper Straße. We recommend you leave your car on one of the parking lots at Campus Nord and use the H-Bahn (suspended monorail system), which conveniently connects the two campuses.
TU Dortmund University has its own train station ("Dortmund Universität"). From there, suburban trains (S-Bahn) leave for Dortmund main station ("Dortmund Hauptbahnhof") and Düsseldorf main station via the "Düsseldorf Airport Train Station" (take S-Bahn number 1, which leaves every 20 or 30 minutes). The university is easily reached from Bochum, Essen, Mülheim an der Ruhr and Duisburg.
You can also take the bus or subway train from Dortmund city to the university: From Dortmund main station, you can take any train bound for the Station "Stadtgarten", usually lines U41, U45, U 47 and U49. At "Stadtgarten" you switch trains and get on line U42 towards "Hombruch". Look out for the Station "An der Palmweide". From the bus stop just across the road, busses bound for TU Dortmund University leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dortmund main station to the stop "Dortmund Kampstraße". From there, take U43 or U44 to the stop "Dortmund Wittener Straße". Switch to bus line 447 and get off at "Dortmund Universität S".
The H-Bahn is one of the hallmarks of TU Dortmund University. There are two stations on Campus Nord. One ("Dortmund Universität S") is directly located at the suburban train stop, which connects the university directly with the city of Dortmund and the rest of the Ruhr Area. Also from this station, there are connections to the "Technologiepark" and (via Campus Süd) Eichlinghofen. The other station is located at the dining hall at Campus Nord and offers a direct connection to Campus Süd every five minutes.
The AirportExpress is a fast and convenient means of transport from Dortmund Airport (DTM) to Dortmund Central Station, taking you there in little more than 20 minutes. From Dortmund Central Station, you can continue to the university campus by interurban railway (S-Bahn). A larger range of international flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the university station.
The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent "Technologiepark".